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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9464

FusionGeneSummary for DCTN4_DCTN4

check button Fusion gene summary
Fusion gene informationFusion gene name: DCTN4_DCTN4
Fusion gene ID: 9464
HgeneTgene
Gene symbol

DCTN4

DCTN4

Gene ID

51164

51164

Gene namedynactin subunit 4dynactin subunit 4
SynonymsDYN4|P62DYN4|P62
Cytomap

5q33.1

5q33.1

Type of geneprotein-codingprotein-coding
Descriptiondynactin subunit 4dynactin 4 (p62)dynactin p62 subunitdynactin subunit p62dynactin subunit 4dynactin 4 (p62)dynactin p62 subunitdynactin subunit p62
Modification date2018052320180523
UniProtAcc

Q9UJW0

Q9UJW0

Ensembl transtripts involved in fusion geneENST00000447998, ENST00000424236, 
ENST00000446090, ENST00000521093, 
ENST00000447998, ENST00000424236, 
ENST00000446090, ENST00000521093, 
Fusion gene scores* DoF score2 X 3 X 1=62 X 3 X 2=12
# samples 33
** MAII scorelog2(3/6*10)=2.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DCTN4 [Title/Abstract] AND DCTN4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF846890DCTN4chr5

150110695

-DCTN4chr5

150110214

+
ChiTaRS3.1AF156165DCTN4chr5

150090527

+DCTN4chr5

150090462

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000447998ENST00000447998DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000447998ENST00000424236DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000447998ENST00000446090DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-intronENST00000447998ENST00000521093DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000424236ENST00000447998DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000424236ENST00000424236DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000424236ENST00000446090DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-intronENST00000424236ENST00000521093DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000446090ENST00000447998DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000446090ENST00000424236DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000446090ENST00000446090DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-intronENST00000446090ENST00000521093DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000521093ENST00000447998DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000521093ENST00000424236DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3CDSENST00000521093ENST00000446090DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-intronENST00000521093ENST00000521093DCTN4chr5

150110695

-DCTN4chr5

150110214

+
intron-3UTRENST00000447998ENST00000447998DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000447998ENST00000424236DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000447998ENST00000446090DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-intronENST00000447998ENST00000521093DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000424236ENST00000447998DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000424236ENST00000424236DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000424236ENST00000446090DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-intronENST00000424236ENST00000521093DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000446090ENST00000447998DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000446090ENST00000424236DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000446090ENST00000446090DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-intronENST00000446090ENST00000521093DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000521093ENST00000447998DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000521093ENST00000424236DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-3UTRENST00000521093ENST00000446090DCTN4chr5

150090527

+DCTN4chr5

150090462

-
intron-intronENST00000521093ENST00000521093DCTN4chr5

150090527

+DCTN4chr5

150090462

-

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FusionProtFeatures for DCTN4_DCTN4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCTN4

Q9UJW0

DCTN4

Q9UJW0

Could have a dual role in dynein targeting and inACTR1A/Arp1 subunit of dynactin pointed-end capping. Could beinvolved in ACTR1A pointed-end binding and in additional roles inlinking dynein and dynactin to the cortical cytoskeleton. Could have a dual role in dynein targeting and inACTR1A/Arp1 subunit of dynactin pointed-end capping. Could beinvolved in ACTR1A pointed-end binding and in additional roles inlinking dynein and dynactin to the cortical cytoskeleton.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCTN4_DCTN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCTN4_DCTN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCTN4_DCTN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCTN4_DCTN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCTN4C0010674Cystic Fibrosis1CTD_human;ORPHANET
HgeneDCTN4C0033817Pseudomonas Infections1CTD_human
TgeneDCTN4C0010674Cystic Fibrosis1CTD_human;ORPHANET
TgeneDCTN4C0033817Pseudomonas Infections1CTD_human