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Fusion gene ID: 9447 |
FusionGeneSummary for DCTD_ECE2 |
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Fusion gene information | Fusion gene name: DCTD_ECE2 | Fusion gene ID: 9447 | Hgene | Tgene | Gene symbol | DCTD | ECE2 | Gene ID | 1635 | 9718 |
Gene name | dCMP deaminase | endothelin converting enzyme 2 | |
Synonyms | - | - | |
Cytomap | 4q35.1 | 3q27.1 | |
Type of gene | protein-coding | protein-coding | |
Description | deoxycytidylate deaminase | endothelin-converting enzyme 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P32321 | ||
Ensembl transtripts involved in fusion gene | ENST00000357067, ENST00000438320, ENST00000510370, ENST00000513383, | ENST00000324557, ENST00000402825, ENST00000359140, ENST00000404464, ENST00000357474, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 4=64 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DCTD [Title/Abstract] AND ECE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | GBM | TCGA-06-0644-01A | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000357067 | ENST00000324557 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000357067 | ENST00000402825 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000357067 | ENST00000359140 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000357067 | ENST00000404464 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000357067 | ENST00000357474 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000438320 | ENST00000324557 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000438320 | ENST00000402825 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000438320 | ENST00000359140 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000438320 | ENST00000404464 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000438320 | ENST00000357474 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000510370 | ENST00000324557 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000510370 | ENST00000402825 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000510370 | ENST00000359140 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000510370 | ENST00000404464 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5CDS-intron | ENST00000510370 | ENST00000357474 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5UTR-intron | ENST00000513383 | ENST00000324557 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5UTR-intron | ENST00000513383 | ENST00000402825 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5UTR-intron | ENST00000513383 | ENST00000359140 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5UTR-intron | ENST00000513383 | ENST00000404464 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
5UTR-intron | ENST00000513383 | ENST00000357474 | DCTD | chr4 | 183836076 | - | ECE2 | chr3 | 184001573 | + |
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FusionProtFeatures for DCTD_ECE2 |
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Hgene | Tgene |
DCTD | ECE2 |
Supplies the nucleotide substrate for thymidylatesynthetase. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DCTD_ECE2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DCTD_ECE2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DCTD | LNX1, CEP76, NUDT18, NIF3L1, DCTD, ELAVL1, FGF12, SDCBP, TXN2, GORASP2, MALSU1, NGRN | ECE2 | UBC, BAG3, CASP10, CD86, SYNE4, KDM1A, RCOR1, RCOR3, RPS6KA2, DHX40, CMPK1, EZR, PNPO, KCNIP4, MTNR1A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DCTD_ECE2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCTD_ECE2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |