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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9446

FusionGeneSummary for DCTD_DCTD

check button Fusion gene summary
Fusion gene informationFusion gene name: DCTD_DCTD
Fusion gene ID: 9446
HgeneTgene
Gene symbol

DCTD

DCTD

Gene ID

1635

1635

Gene namedCMP deaminasedCMP deaminase
Synonyms--
Cytomap

4q35.1

4q35.1

Type of geneprotein-codingprotein-coding
Descriptiondeoxycytidylate deaminasedeoxycytidylate deaminase
Modification date2018052320180523
UniProtAcc

P32321

P32321

Ensembl transtripts involved in fusion geneENST00000357067, ENST00000438320, 
ENST00000510370, ENST00000513383, 
ENST00000357067, ENST00000438320, 
ENST00000510370, ENST00000513383, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DCTD [Title/Abstract] AND DCTD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW946723DCTDchr4

183811422

-DCTDchr4

183811364

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000357067ENST00000357067DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000357067ENST00000438320DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000357067ENST00000510370DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000357067ENST00000513383DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-3UTRENST00000438320ENST00000357067DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000438320ENST00000438320DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000438320ENST00000510370DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000438320ENST00000513383DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-3UTRENST00000510370ENST00000357067DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000510370ENST00000438320DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000510370ENST00000510370DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000510370ENST00000513383DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-3UTRENST00000513383ENST00000357067DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000513383ENST00000438320DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000513383ENST00000510370DCTDchr4

183811422

-DCTDchr4

183811364

+
intron-intronENST00000513383ENST00000513383DCTDchr4

183811422

-DCTDchr4

183811364

+

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FusionProtFeatures for DCTD_DCTD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCTD

P32321

DCTD

P32321

Supplies the nucleotide substrate for thymidylatesynthetase. Supplies the nucleotide substrate for thymidylatesynthetase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCTD_DCTD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCTD_DCTD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCTD_DCTD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCTD_DCTD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource