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Fusion gene ID: 9445 |
FusionGeneSummary for DCSTAMP_TSPAN31 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DCSTAMP_TSPAN31 | Fusion gene ID: 9445 | Hgene | Tgene | Gene symbol | DCSTAMP | TSPAN31 | Gene ID | 81501 | 6302 |
| Gene name | dendrocyte expressed seven transmembrane protein | tetraspanin 31 | |
| Synonyms | FIND|TM7SF4|hDC-STAMP | SAS | |
| Cytomap | 8q22.3 | 12q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dendritic cell-specific transmembrane proteinDC-specific transmembrane proteinDendritic cells (DC)-specific transmembrane proteinIL-4-induced proteinIL-Four (IL-4) inducedIL-Four INDucedIL-four-induced proteintransmembrane 7 superfamily member 4 | tetraspanin-31sarcoma-amplified sequencetransmembrane 4 proteintspan-31 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H295 | Q12999 | |
| Ensembl transtripts involved in fusion gene | ENST00000297581, ENST00000517991, ENST00000520080, | ENST00000553221, ENST00000257910, ENST00000547992, ENST00000547472, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 11 X 4 X 4=176 |
| # samples | 1 | 10 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(10/176*10)=-0.815575428862573 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DCSTAMP [Title/Abstract] AND TSPAN31 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DCSTAMP | GO:0071353 | cellular response to interleukin-4 | 15601667 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A1KZ-01A | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000297581 | ENST00000553221 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-3UTR | ENST00000297581 | ENST00000257910 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-intron | ENST00000297581 | ENST00000547992 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-intron | ENST00000297581 | ENST00000547472 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-3UTR | ENST00000517991 | ENST00000553221 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-3UTR | ENST00000517991 | ENST00000257910 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-intron | ENST00000517991 | ENST00000547992 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-intron | ENST00000517991 | ENST00000547472 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-3UTR | ENST00000520080 | ENST00000553221 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-3UTR | ENST00000520080 | ENST00000257910 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-intron | ENST00000520080 | ENST00000547992 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
| intron-intron | ENST00000520080 | ENST00000547472 | DCSTAMP | chr8 | 105352668 | + | TSPAN31 | chr12 | 58140372 | + |
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FusionProtFeatures for DCSTAMP_TSPAN31 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DCSTAMP | TSPAN31 |
| Probable cell surface receptor that plays several rolesin cellular fusion, cell differentiation, bone and immunehomeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis.Cooperates with OCSTAMP in modulating cell-cell fusion in bothosteoclasts and foreign body giant cells (FBGCs). Participates inosteoclast bone resorption. Involved in inducing the expression oftartrate-resistant acid phosphatase in osteoclast precursors.Plays a role in haematopoietic stem cell differentiation of bonemarrow cells toward the myeloid lineage. Inhibits the developmentof neutrophilic granulocytes. Plays also a role in the regulationof dendritic cell (DC) antigen presentation activity bycontrolling phagocytic activity. Involved in the maintenance ofimmune self-tolerance and avoidance of autoimmune reactions. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DCSTAMP_TSPAN31 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DCSTAMP_TSPAN31 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DCSTAMP | OS9 | TSPAN31 | ELAVL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DCSTAMP_TSPAN31 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCSTAMP_TSPAN31 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DCSTAMP | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | DCSTAMP | C0029401 | Osteitis Deformans | 1 | CTD_human |
| Hgene | DCSTAMP | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
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