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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9430

FusionGeneSummary for DCN_SSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCN_SSR1
Fusion gene ID: 9430
HgeneTgene
Gene symbol

DCN

SSR1

Gene ID

1634

6745

Gene namedecorinsignal sequence receptor subunit 1
SynonymsCSCD|DSPG2|PG40|PGII|PGS2|SLRR1BTRAPA
Cytomap

12q21.33

6p24.3

Type of geneprotein-codingprotein-coding
Descriptiondecorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1Btranslocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunit
Modification date2018052220180523
UniProtAcc

P07585

P43307

Ensembl transtripts involved in fusion geneENST00000052754, ENST00000425043, 
ENST00000393155, ENST00000228329, 
ENST00000303320, ENST00000552962, 
ENST00000441303, ENST00000420120, 
ENST00000547568, ENST00000456569, 
ENST00000546370, ENST00000546745, 
ENST00000550099, ENST00000551354, 
ENST00000548768, 
ENST00000488834, 
ENST00000474597, ENST00000244763, 
ENST00000397511, ENST00000534851, 
ENST00000489567, ENST00000479365, 
ENST00000462112, 
Fusion gene scores* DoF score5 X 5 X 1=255 X 6 X 3=90
# samples 56
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCN [Title/Abstract] AND SSR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCN

GO:0010508

positive regulation of autophagy

23798385

HgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

HgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

HgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

HgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

HgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1M14219DCNchr12

91539704

-SSR1chr6

7288539

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000052754ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000052754ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000052754ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000052754ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000052754ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000052754ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000052754ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000052754ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000425043ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000425043ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000425043ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000425043ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000425043ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000425043ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000425043ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000425043ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000393155ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000393155ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000393155ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000393155ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000393155ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000393155ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000393155ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000393155ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000228329ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000228329ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000228329ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000228329ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000228329ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000228329ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000228329ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000228329ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000303320ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000303320ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000303320ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000303320ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000303320ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000303320ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000303320ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000303320ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000552962ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000552962ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000552962ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000552962ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000552962ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000552962ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000552962ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000552962ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000441303ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000441303ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000441303ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000441303ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000441303ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000441303ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000441303ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000441303ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000420120ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000420120ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000420120ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000420120ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000420120ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000420120ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000420120ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000420120ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000547568ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000547568ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000547568ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000547568ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000547568ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000547568ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000547568ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000547568ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000456569ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000456569ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000456569ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000456569ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000456569ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000456569ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000456569ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000456569ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546370ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546370ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000546370ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000546370ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000546370ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546370ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546370ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546370ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546745ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546745ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000546745ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000546745ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000546745ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546745ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546745ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000546745ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000550099ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000550099ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000550099ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000550099ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000550099ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000550099ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000550099ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000550099ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000551354ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000551354ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000551354ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000551354ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000551354ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000551354ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000551354ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000551354ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000548768ENST00000488834DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000548768ENST00000474597DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000548768ENST00000244763DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000548768ENST00000397511DCNchr12

91539704

-SSR1chr6

7288539

-
intron-3UTRENST00000548768ENST00000534851DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000548768ENST00000489567DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000548768ENST00000479365DCNchr12

91539704

-SSR1chr6

7288539

-
intron-intronENST00000548768ENST00000462112DCNchr12

91539704

-SSR1chr6

7288539

-

Top

FusionProtFeatures for DCN_SSR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCN

P07585

SSR1

P43307

May affect the rate of fibrils formation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DCN_SSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DCN_SSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DCN_SSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDCNP07585DB03754TromethamineDecorinsmall moleculeapproved

Top

RelatedDiseases for DCN_SSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCNC0014170Endometrial Neoplasms1CTD_human
HgeneDCNC0016059Fibrosis1CTD_human
HgeneDCNC0027707Nephritis, Interstitial1CTD_human
HgeneDCNC0151744Myocardial Ischemia1CTD_human
HgeneDCNC0238288Muscular Dystrophy, Facioscapulohumeral1CTD_human