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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9427

FusionGeneSummary for DCN_CRIPAK

check button Fusion gene summary
Fusion gene informationFusion gene name: DCN_CRIPAK
Fusion gene ID: 9427
HgeneTgene
Gene symbol

DCN

CRIPAK

Gene ID

1634

285464

Gene namedecorincysteine rich PAK1 inhibitor
SynonymsCSCD|DSPG2|PG40|PGII|PGS2|SLRR1B-
Cytomap

12q21.33

4p16.3

Type of geneprotein-codingprotein-coding
Descriptiondecorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1Bcysteine-rich PAK1 inhibitorcysteine-rich inhibitor of PAK1
Modification date2018052220180519
UniProtAcc

P07585

Q8N1N5

Ensembl transtripts involved in fusion geneENST00000052754, ENST00000425043, 
ENST00000393155, ENST00000228329, 
ENST00000303320, ENST00000552962, 
ENST00000441303, ENST00000420120, 
ENST00000547568, ENST00000456569, 
ENST00000546370, ENST00000546745, 
ENST00000550099, ENST00000551354, 
ENST00000548768, 
ENST00000324803, 
Fusion gene scores* DoF score5 X 5 X 1=251 X 1 X 1=1
# samples 51
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: DCN [Title/Abstract] AND CRIPAK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCN

GO:0010508

positive regulation of autophagy

23798385

HgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

HgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

HgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

HgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

HgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385

TgeneCRIPAK

GO:0006469

negative regulation of protein kinase activity

16278681

TgeneCRIPAK

GO:0033147

negative regulation of intracellular estrogen receptor signaling pathway

16278681

TgeneCRIPAK

GO:0043627

response to estrogen

16278681

TgeneCRIPAK

GO:0051493

regulation of cytoskeleton organization

16278681


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV569111DCNchr12

91572239

-CRIPAKchr4

1387247

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000052754ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000425043ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000393155ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000228329ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000303320ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000552962ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000441303ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000420120ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000547568ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000456569ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000546370ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000546745ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000550099ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000551354ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+
intron-5UTRENST00000548768ENST00000324803DCNchr12

91572239

-CRIPAKchr4

1387247

+

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FusionProtFeatures for DCN_CRIPAK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCN

P07585

CRIPAK

Q8N1N5

May affect the rate of fibrils formation. Negative regulator of PAK1. It has been suggested thatthe lost of CRIPAK in breast tumors might contribute to hormonalindependence. {ECO:0000269|PubMed:16278681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCN_CRIPAK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCN_CRIPAK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCN_CRIPAK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDCNP07585DB03754TromethamineDecorinsmall moleculeapproved

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RelatedDiseases for DCN_CRIPAK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCNC0014170Endometrial Neoplasms1CTD_human
HgeneDCNC0016059Fibrosis1CTD_human
HgeneDCNC0027707Nephritis, Interstitial1CTD_human
HgeneDCNC0151744Myocardial Ischemia1CTD_human
HgeneDCNC0238288Muscular Dystrophy, Facioscapulohumeral1CTD_human