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Fusion gene ID: 9427 |
FusionGeneSummary for DCN_CRIPAK |
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Fusion gene information | Fusion gene name: DCN_CRIPAK | Fusion gene ID: 9427 | Hgene | Tgene | Gene symbol | DCN | CRIPAK | Gene ID | 1634 | 285464 |
Gene name | decorin | cysteine rich PAK1 inhibitor | |
Synonyms | CSCD|DSPG2|PG40|PGII|PGS2|SLRR1B | - | |
Cytomap | 12q21.33 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | decorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1B | cysteine-rich PAK1 inhibitorcysteine-rich inhibitor of PAK1 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P07585 | Q8N1N5 | |
Ensembl transtripts involved in fusion gene | ENST00000052754, ENST00000425043, ENST00000393155, ENST00000228329, ENST00000303320, ENST00000552962, ENST00000441303, ENST00000420120, ENST00000547568, ENST00000456569, ENST00000546370, ENST00000546745, ENST00000550099, ENST00000551354, ENST00000548768, | ENST00000324803, | |
Fusion gene scores | * DoF score | 5 X 5 X 1=25 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DCN [Title/Abstract] AND CRIPAK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DCN | GO:0010508 | positive regulation of autophagy | 23798385 |
Hgene | DCN | GO:0010596 | negative regulation of endothelial cell migration | 23798385 |
Hgene | DCN | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 23798385 |
Hgene | DCN | GO:0016239 | positive regulation of macroautophagy | 23798385 |
Hgene | DCN | GO:0016525 | negative regulation of angiogenesis | 23978385 |
Hgene | DCN | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway | 23798385 |
Tgene | CRIPAK | GO:0006469 | negative regulation of protein kinase activity | 16278681 |
Tgene | CRIPAK | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 16278681 |
Tgene | CRIPAK | GO:0043627 | response to estrogen | 16278681 |
Tgene | CRIPAK | GO:0051493 | regulation of cytoskeleton organization | 16278681 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CV569111 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000052754 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000425043 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000393155 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000228329 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000303320 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000552962 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000441303 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000420120 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000547568 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000456569 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000546370 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000546745 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000550099 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000551354 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
intron-5UTR | ENST00000548768 | ENST00000324803 | DCN | chr12 | 91572239 | - | CRIPAK | chr4 | 1387247 | + |
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FusionProtFeatures for DCN_CRIPAK |
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Hgene | Tgene |
DCN | CRIPAK |
May affect the rate of fibrils formation. | Negative regulator of PAK1. It has been suggested thatthe lost of CRIPAK in breast tumors might contribute to hormonalindependence. {ECO:0000269|PubMed:16278681}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DCN_CRIPAK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DCN_CRIPAK |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DCN_CRIPAK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | DCN | P07585 | DB03754 | Tromethamine | Decorin | small molecule | approved |
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RelatedDiseases for DCN_CRIPAK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DCN | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | DCN | C0016059 | Fibrosis | 1 | CTD_human |
Hgene | DCN | C0027707 | Nephritis, Interstitial | 1 | CTD_human |
Hgene | DCN | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | DCN | C0238288 | Muscular Dystrophy, Facioscapulohumeral | 1 | CTD_human |