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Fusion gene ID: 9423 |
FusionGeneSummary for DCLK2_UST |
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Fusion gene information | Fusion gene name: DCLK2_UST | Fusion gene ID: 9423 | Hgene | Tgene | Gene symbol | DCLK2 | UST | Gene ID | 166614 | 10090 |
Gene name | doublecortin like kinase 2 | uronyl 2-sulfotransferase | |
Synonyms | CL2|CLICK-II|CLICK2|CLIK2|DCAMKL2|DCDC3|DCDC3B|DCK2 | 2OST | |
Cytomap | 4q31.23-q31.3 | 6q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase DCLK2CaMK-like CREB regulatory kinase 2doublecortin and CaM kinase-like 2doublecortin domain-containing protein 3Bdoublecortin-like and CAM kinase-like 2 | uronyl 2-sulfotransferasedermatan/chondroitin sulfate 2-sulfotransferase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8N568 | Q9Y2C2 | |
Ensembl transtripts involved in fusion gene | ENST00000296550, ENST00000506325, ENST00000302176, ENST00000507694, | ENST00000367463, ENST00000466695, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 2 X 4=32 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DCLK2 [Title/Abstract] AND UST [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-ER-A19H-06A | DCLK2 | chr4 | 151000600 | + | UST | chr6 | 149394969 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000296550 | ENST00000367463 | DCLK2 | chr4 | 151000600 | + | UST | chr6 | 149394969 | + |
5CDS-3UTR | ENST00000296550 | ENST00000466695 | DCLK2 | chr4 | 151000600 | + | UST | chr6 | 149394969 | + |
Frame-shift | ENST00000506325 | ENST00000367463 | DCLK2 | chr4 | 151000600 | + | UST | chr6 | 149394969 | + |
5CDS-3UTR | ENST00000506325 | ENST00000466695 | DCLK2 | chr4 | 151000600 | + | UST | chr6 | 149394969 | + |
Frame-shift | ENST00000302176 | ENST00000367463 | DCLK2 | chr4 | 151000600 | + | UST | chr6 | 149394969 | + |
5CDS-3UTR | ENST00000302176 | ENST00000466695 | DCLK2 | chr4 | 151000600 | + | UST | chr6 | 149394969 | + |
intron-3CDS | ENST00000507694 | ENST00000367463 | DCLK2 | chr4 | 151000600 | + | UST | chr6 | 149394969 | + |
intron-3UTR | ENST00000507694 | ENST00000466695 | DCLK2 | chr4 | 151000600 | + | UST | chr6 | 149394969 | + |
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FusionProtFeatures for DCLK2_UST |
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Hgene | Tgene |
DCLK2 | UST |
Protein kinase with a significantly reduced C(a2+)/CAMaffinity and dependence compared to other members of the CaMKfamily. May play a role in the down-regulation of CRE-dependentgene activation probably by phosphorylation of the CREBcoactivator CRTC2/TORC2 and the resulting retention of TORC2 inthe cytoplasm (By similarity). {ECO:0000250}. | Sulfotransferase that catalyzes the transfer of sulfateto the position 2 of uronyl residues. Has mainly activity towardiduronyl residues in dermatan sulfate, and weaker activity towardglucuronyl residues of chondroitin sulfate. Has no activity towarddesulfated N-resulfated heparin. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DCLK2_UST |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DCLK2_UST |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DCLK2 | HSP90AA1, TSC22D3, ENO1, KRAS, DCTN1 | UST | ELAVL1, CUL3, MRAP2, SLC27A6, INHBE, PPT2, CANX, DCAKD, PON2, GLG1, GOLIM4, XYLT2, MAN1A1, JAG2, OCIAD1, LDLR, IMPAD1, ERO1LB, OMA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DCLK2_UST |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCLK2_UST |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | UST | C0014175 | Endometriosis | 1 | CTD_human |