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Fusion gene ID: 9421 |
FusionGeneSummary for DCLK1_SERPINE3 |
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Fusion gene information | Fusion gene name: DCLK1_SERPINE3 | Fusion gene ID: 9421 | Hgene | Tgene | Gene symbol | DCLK1 | SERPINE3 | Gene ID | 9201 | 647174 |
Gene name | doublecortin like kinase 1 | serpin family E member 3 | |
Synonyms | CL1|CLICK1|DCAMKL1|DCDC3A|DCLK | - | |
Cytomap | 13q13.3 | 13q14.3 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1 | serpin E3nexin-related serine protease inhibitorserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | O15075 | A8MV23 | |
Ensembl transtripts involved in fusion gene | ENST00000360631, ENST00000255448, ENST00000379892, ENST00000379893, ENST00000460982, | ENST00000524365, ENST00000521255, ENST00000400389, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DCLK1 [Title/Abstract] AND SERPINE3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A09V-01A | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000360631 | ENST00000524365 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
Frame-shift | ENST00000360631 | ENST00000521255 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
Frame-shift | ENST00000360631 | ENST00000400389 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
Frame-shift | ENST00000255448 | ENST00000524365 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
Frame-shift | ENST00000255448 | ENST00000521255 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
Frame-shift | ENST00000255448 | ENST00000400389 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
Frame-shift | ENST00000379892 | ENST00000524365 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
Frame-shift | ENST00000379892 | ENST00000521255 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
Frame-shift | ENST00000379892 | ENST00000400389 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
intron-3CDS | ENST00000379893 | ENST00000524365 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
intron-3CDS | ENST00000379893 | ENST00000521255 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
intron-3CDS | ENST00000379893 | ENST00000400389 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
intron-3CDS | ENST00000460982 | ENST00000524365 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
intron-3CDS | ENST00000460982 | ENST00000521255 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
intron-3CDS | ENST00000460982 | ENST00000400389 | DCLK1 | chr13 | 36686006 | - | SERPINE3 | chr13 | 51935414 | + |
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FusionProtFeatures for DCLK1_SERPINE3 |
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Hgene | Tgene |
DCLK1 | SERPINE3 |
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developingbrain. May also participate in functions of the mature nervoussystem. | Probable serine protease inhibitor. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DCLK1_SERPINE3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DCLK1_SERPINE3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DCLK1 | APP, CFTR, HAX1, NUFIP1, CDCA8, DGUOK, DNAAF2, DCX, SLC4A1AP, CEP170, SPICE1, CEP128, DCTN1, LCA5, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, ZNF638, SRSF12, SYDE1, RTKN, MAST3, PPM1H, AGAP1, CDC25B, CDK16, DENND4C, FAM110B, USP21, FAM53C, ANKRD34A, MAPKAP1, FAM110A, CGN, HDAC4, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, CAMSAP2, MELK, PLEKHA7, CDC25C, LPIN3, KIF1C, GIGYF2, DEPDC1B, NAV1, MLLT4, DENND4A, PTPN14, STARD13, RPTOR, PLEKHA5, SH3BP4, HDAC7, EDC3, SH3RF3, LARP1, RAB3IP, INPP5E | SERPINE3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DCLK1_SERPINE3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCLK1_SERPINE3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DCLK1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | DCLK1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | DCLK1 | C0036341 | Schizophrenia | 1 | PSYGENET |