|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 9420 |
FusionGeneSummary for DCLK1_RCBTB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DCLK1_RCBTB1 | Fusion gene ID: 9420 | Hgene | Tgene | Gene symbol | DCLK1 | RCBTB1 | Gene ID | 9201 | 55213 |
| Gene name | doublecortin like kinase 1 | RCC1 and BTB domain containing protein 1 | |
| Synonyms | CL1|CLICK1|DCAMKL1|DCDC3A|DCLK | CLLD7|CLLL7|GLP|RDEOA | |
| Cytomap | 13q13.3 | 13q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1 | RCC1 and BTB domain-containing protein 1CLL deletion region gene 7 proteinGDP/GTP exchange factor (GEF)-like proteinchronic lymphocytic leukemia deletion region gene 7 proteinregulator of chromosome condensation (RCC1) and BTB (POZ) domain containing | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | O15075 | Q8NDN9 | |
| Ensembl transtripts involved in fusion gene | ENST00000360631, ENST00000255448, ENST00000379892, ENST00000379893, ENST00000460982, | ENST00000258646, ENST00000378302, ENST00000471984, ENST00000546015, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DCLK1 [Title/Abstract] AND RCBTB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A0CW-01A | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000360631 | ENST00000258646 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| In-frame | ENST00000360631 | ENST00000378302 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| 5CDS-5UTR | ENST00000360631 | ENST00000471984 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| 5CDS-intron | ENST00000360631 | ENST00000546015 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| Frame-shift | ENST00000255448 | ENST00000258646 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| In-frame | ENST00000255448 | ENST00000378302 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| 5CDS-5UTR | ENST00000255448 | ENST00000471984 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| 5CDS-intron | ENST00000255448 | ENST00000546015 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| Frame-shift | ENST00000379892 | ENST00000258646 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| In-frame | ENST00000379892 | ENST00000378302 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| 5CDS-5UTR | ENST00000379892 | ENST00000471984 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| 5CDS-intron | ENST00000379892 | ENST00000546015 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| intron-3CDS | ENST00000379893 | ENST00000258646 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| intron-3CDS | ENST00000379893 | ENST00000378302 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| intron-5UTR | ENST00000379893 | ENST00000471984 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| intron-intron | ENST00000379893 | ENST00000546015 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| intron-3CDS | ENST00000460982 | ENST00000258646 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| intron-3CDS | ENST00000460982 | ENST00000378302 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| intron-5UTR | ENST00000460982 | ENST00000471984 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
| intron-intron | ENST00000460982 | ENST00000546015 | DCLK1 | chr13 | 36445361 | - | RCBTB1 | chr13 | 50108398 | - |
Top |
FusionProtFeatures for DCLK1_RCBTB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DCLK1 | RCBTB1 |
| Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developingbrain. May also participate in functions of the mature nervoussystem. | May be involved in cell cycle regulation by chromatinremodeling. {ECO:0000269|PubMed:11306461}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for DCLK1_RCBTB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DCLK1_ENST00000360631_chr13_36445361_-_RCBTB1_ENST00000378302_chr13_50108398_-_360aa MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLAD LTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENK DFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFL LDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSGFRRILLXVLHQSFDRSYTDCSILANGWPSAKGIHCXSQXMWSLXEL >In-frame_DCLK1_ENST00000255448_chr13_36445361_-_RCBTB1_ENST00000378302_chr13_50108398_-_360aa MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLAD LTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENK DFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFL LDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSGFRRILLXVLHQSFDRSYTDCSILANGWPSAKGIHCXSQXMWSLXEL >In-frame_DCLK1_ENST00000379892_chr13_36445361_-_RCBTB1_ENST00000378302_chr13_50108398_-_360aa MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLAD LTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENK DFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFL LDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSGFRRILLXVLHQSFDRSYTDCSILANGWPSAKGIHCXSQXMWSLXEL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DCLK1_ENST00000360631_chr13_36445361_-_RCBTB1_ENST00000378302_chr13_50108398_-_1081nt ATGTCCTTCGGCAGAGACATGGAGCTGGAGCACTTCGACGAGCGGGATAAGGCGCAGAGATACAGCCGAGGGTCGCGGGTGAACGGCCTG CCGAGCCCGACGCACAGCGCCCACTGCAGCTTCTACCGCACCCGCACGCTGCAGACGCTCAGCTCCGAGAAGAAGGCCAAGAAAGTTCGT TTCTATCGAAACGGAGATCGATACTTCAAAGGGATTGTGTATGCCATCTCCCCAGACCGGTTCCGATCTTTTGAGGCCCTGCTGGCTGAT TTGACCCGAACTCTGTCGGATAACGTGAATTTGCCCCAGGGAGTGAGAACAATCTACACCATTGATGGGCTCAAGAAGATTTCCAGCCTG GACCAACTGGTGGAAGGAGAGAGTTATGTATGTGGCTCCATAGAGCCCTTCAAGAAACTGGAGTACACCAAGAATGTGAACCCCAACTGG TCGGTGAACGTCAAGACCACCTCGGCTTCTCGGGCAGTGTCTTCACTGGCCACTGCCAAAGGAAGCCCTTCAGAGGTGCGAGAGAATAAG GATTTCATTCGGCCCAAGCTGGTCACCATCATCAGAAGTGGCGTGAAGCCACGGAAAGCTGTCAGGATTCTGCTGAACAAGAAAACGGCT CATTCCTTTGAGCAGGTCCTCACCGATATCACCGATGCCATCAAGCTGGACTCGGGAGTGGTGAAACGCCTGTACACGTTGGATGGGAAA CAGGTGATGTGCCTTCAGGACTTTTTTGGTGATGATGACATTTTTATTGCATGTGGACCGGAGAAGTTCCGTTACCAGGATGATTTCTTG CTAGATGAAAGTGAATGTCGAGTGGTAAAGTCCACTTCTTACACCAAAATAGCTTCATCATCCCGCAGGAGCACCACCAAGAGCCCAGGA CCGTCCAGGCGTAGCAAGTCCCCTGCCTCCACCAGCTCAGGATTTAGAAGAATTCTGCTTTAAGTTTTGCATCAATCATTTGACAGAAGT TACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATTGCTAAAGCCAGTAAATGTGGAGCCTTTAAGAACTG >In-frame_DCLK1_ENST00000255448_chr13_36445361_-_RCBTB1_ENST00000378302_chr13_50108398_-_1081nt ATGTCCTTCGGCAGAGACATGGAGCTGGAGCACTTCGACGAGCGGGATAAGGCGCAGAGATACAGCCGAGGGTCGCGGGTGAACGGCCTG CCGAGCCCGACGCACAGCGCCCACTGCAGCTTCTACCGCACCCGCACGCTGCAGACGCTCAGCTCCGAGAAGAAGGCCAAGAAAGTTCGT TTCTATCGAAACGGAGATCGATACTTCAAAGGGATTGTGTATGCCATCTCCCCAGACCGGTTCCGATCTTTTGAGGCCCTGCTGGCTGAT TTGACCCGAACTCTGTCGGATAACGTGAATTTGCCCCAGGGAGTGAGAACAATCTACACCATTGATGGGCTCAAGAAGATTTCCAGCCTG GACCAACTGGTGGAAGGAGAGAGTTATGTATGTGGCTCCATAGAGCCCTTCAAGAAACTGGAGTACACCAAGAATGTGAACCCCAACTGG TCGGTGAACGTCAAGACCACCTCGGCTTCTCGGGCAGTGTCTTCACTGGCCACTGCCAAAGGAAGCCCTTCAGAGGTGCGAGAGAATAAG GATTTCATTCGGCCCAAGCTGGTCACCATCATCAGAAGTGGCGTGAAGCCACGGAAAGCTGTCAGGATTCTGCTGAACAAGAAAACGGCT CATTCCTTTGAGCAGGTCCTCACCGATATCACCGATGCCATCAAGCTGGACTCGGGAGTGGTGAAACGCCTGTACACGTTGGATGGGAAA CAGGTGATGTGCCTTCAGGACTTTTTTGGTGATGATGACATTTTTATTGCATGTGGACCGGAGAAGTTCCGTTACCAGGATGATTTCTTG CTAGATGAAAGTGAATGTCGAGTGGTAAAGTCCACTTCTTACACCAAAATAGCTTCATCATCCCGCAGGAGCACCACCAAGAGCCCAGGA CCGTCCAGGCGTAGCAAGTCCCCTGCCTCCACCAGCTCAGGATTTAGAAGAATTCTGCTTTAAGTTTTGCATCAATCATTTGACAGAAGT TACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATTGCTAAAGCCAGTAAATGTGGAGCCTTTAAGAACTG >In-frame_DCLK1_ENST00000379892_chr13_36445361_-_RCBTB1_ENST00000378302_chr13_50108398_-_1081nt ATGTCCTTCGGCAGAGACATGGAGCTGGAGCACTTCGACGAGCGGGATAAGGCGCAGAGATACAGCCGAGGGTCGCGGGTGAACGGCCTG CCGAGCCCGACGCACAGCGCCCACTGCAGCTTCTACCGCACCCGCACGCTGCAGACGCTCAGCTCCGAGAAGAAGGCCAAGAAAGTTCGT TTCTATCGAAACGGAGATCGATACTTCAAAGGGATTGTGTATGCCATCTCCCCAGACCGGTTCCGATCTTTTGAGGCCCTGCTGGCTGAT TTGACCCGAACTCTGTCGGATAACGTGAATTTGCCCCAGGGAGTGAGAACAATCTACACCATTGATGGGCTCAAGAAGATTTCCAGCCTG GACCAACTGGTGGAAGGAGAGAGTTATGTATGTGGCTCCATAGAGCCCTTCAAGAAACTGGAGTACACCAAGAATGTGAACCCCAACTGG TCGGTGAACGTCAAGACCACCTCGGCTTCTCGGGCAGTGTCTTCACTGGCCACTGCCAAAGGAAGCCCTTCAGAGGTGCGAGAGAATAAG GATTTCATTCGGCCCAAGCTGGTCACCATCATCAGAAGTGGCGTGAAGCCACGGAAAGCTGTCAGGATTCTGCTGAACAAGAAAACGGCT CATTCCTTTGAGCAGGTCCTCACCGATATCACCGATGCCATCAAGCTGGACTCGGGAGTGGTGAAACGCCTGTACACGTTGGATGGGAAA CAGGTGATGTGCCTTCAGGACTTTTTTGGTGATGATGACATTTTTATTGCATGTGGACCGGAGAAGTTCCGTTACCAGGATGATTTCTTG CTAGATGAAAGTGAATGTCGAGTGGTAAAGTCCACTTCTTACACCAAAATAGCTTCATCATCCCGCAGGAGCACCACCAAGAGCCCAGGA CCGTCCAGGCGTAGCAAGTCCCCTGCCTCCACCAGCTCAGGATTTAGAAGAATTCTGCTTTAAGTTTTGCATCAATCATTTGACAGAAGT TACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATTGCTAAAGCCAGTAAATGTGGAGCCTTTAAGAACTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DCLK1_ENST00000360631_chr13_36445361_-_RCBTB1_ENST00000378302_chr13_50108398_-_3461nt GCACATCCCTGCACTAGTGGCCGCAACCGAGGCGCCGCGCTCCAGCAGCTGCTGCCGCCCAGCCCGGCCCCGCCGCCGCCCCCCAGCCCT GCAGCCCCGCAGCCCCGGCCGCGCCCAGCCCGGCGAGGACAGCACCAGGAGGCGGCCCCCAGCGCGGCCACAAAGACCCCCGGCGGCGTC TCTCCGCGGACCGGTCCTACTTGAAGTCCATCATGTCCTTCGGCAGAGACATGGAGCTGGAGCACTTCGACGAGCGGGATAAGGCGCAGA GATACAGCCGAGGGTCGCGGGTGAACGGCCTGCCGAGCCCGACGCACAGCGCCCACTGCAGCTTCTACCGCACCCGCACGCTGCAGACGC TCAGCTCCGAGAAGAAGGCCAAGAAAGTTCGTTTCTATCGAAACGGAGATCGATACTTCAAAGGGATTGTGTATGCCATCTCCCCAGACC GGTTCCGATCTTTTGAGGCCCTGCTGGCTGATTTGACCCGAACTCTGTCGGATAACGTGAATTTGCCCCAGGGAGTGAGAACAATCTACA CCATTGATGGGCTCAAGAAGATTTCCAGCCTGGACCAACTGGTGGAAGGAGAGAGTTATGTATGTGGCTCCATAGAGCCCTTCAAGAAAC TGGAGTACACCAAGAATGTGAACCCCAACTGGTCGGTGAACGTCAAGACCACCTCGGCTTCTCGGGCAGTGTCTTCACTGGCCACTGCCA AAGGAAGCCCTTCAGAGGTGCGAGAGAATAAGGATTTCATTCGGCCCAAGCTGGTCACCATCATCAGAAGTGGCGTGAAGCCACGGAAAG CTGTCAGGATTCTGCTGAACAAGAAAACGGCTCATTCCTTTGAGCAGGTCCTCACCGATATCACCGATGCCATCAAGCTGGACTCGGGAG TGGTGAAACGCCTGTACACGTTGGATGGGAAACAGGTGATGTGCCTTCAGGACTTTTTTGGTGATGATGACATTTTTATTGCATGTGGAC CGGAGAAGTTCCGTTACCAGGATGATTTCTTGCTAGATGAAAGTGAATGTCGAGTGGTAAAGTCCACTTCTTACACCAAAATAGCTTCAT CATCCCGCAGGAGCACCACCAAGAGCCCAGGACCGTCCAGGCGTAGCAAGTCCCCTGCCTCCACCAGCTCAGGATTTAGAAGAATTCTGC TTTAAGTTTTGCATCAATCATTTGACAGAAGTTACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATTGCT AAAGCCAGTAAATGTGGAGCCTTTAAGAACTGAAGCGCAAGGCTGCTGGGTTCTGTGTGAGTGCTCTGGGGCACTGTTGAGGATGTGTCC AGTTTGTGCTCTACGGGTGATGTGATTCTGCAGGTAAAAGACCATCAGGTTGTTTTTTTCCACATCTGGGACACAGTTGTTTGTGTAGGA ACATAACAAGGGTGTACGGCTTTTCTTGAGCCCATTTTAAACAACCCTTGTTTCCAGATAAGTGTATTTTAAATGTGACCTTTCGTAAAT TTGGGCTGGAACATGTAAAAGGGTGAAAGTTAGTCGTTTTTGGTCTTCTTTTCATTTTTGATTAGAGGAACTTCTGAACTTGGAAAGGGG AAGTTGGCAGCAACTCTCCTGGGCCACGTATCAACAATCTTCTGACAGCAGGAGCAGTGATAGTTGGGGAATTGTGAGATGAATGGAGAG GCCCCATCGTGAATTAAAGATGCTGACCTGGGGATTGTTAAGTGCTGCCTTAGTTGCTAGTTTAGTAGCCTTACTGTGAAGGAATAATTA AGATTGTTTCAGACTTTTGTTTGTGTGCTTGCGTTGATGACTTTTTTAACTTCAAGATAAATCAAAGTAATAAGTTTAACGTATATTAAA CCTGTTGAAATGATAATTATGTAAAGATAAATATTCTAGGTTAGTCAAGATTTCTCTTAAGATTTAAGTGCATAAAGAATAGTAATTTAG AAGTATCCGTGAAAAGTTGATAATGAAAGAAATTTGATGAAGGTGAATATTTTATAAATTAGAATCTCCACTACTTATCCAATGGTGTTT TATTTCATTAAGGTAGAACTTGAGAACTCAAGTTTAAATTGTCCCCCACCACCTTCTTCTATAAATGCAAACTTAAGAGGAAAATAATGA CATGTATAGTATACTCTTGCCTTCCTAAATTATGACTGCTGAATCATCATATCTACTATATATGACTGGAAGAAGTGGTTCTTCAAGTCA ACCCTCTTACAAGACTTAGTGGAATTTGCTTTATCTACTTTAGGCCAAATCCATCACACATTGGCTTATGTGAAACTTTATCATCTTTCA CTTTTGGTTTTCCTCTGTTTTTAAACATCTTAGGTATAACAGCACAATTTCACCTTGAAAAAGCACCAAAATTATGGTGTTCCTGAAAAG ATCCTATTAAAAGACAGTAGTTTATTTGAACTGGTTATGGAAGGTGACTTTGGGATGTAAGAGTGTTCAACTGTGAGTTTCATCATGTGT GTCCGTTGAGCTTGCTTTTAAGAGCAATGTTTTGCTTTGCTCTCTGGTCCATGAACTCATTTCCATTTGAGTGAGTTCCCTTAGTGAATT TTGTCTCCTGCTTGGAAAGTCTCTCTTCTGAACCTGGAGCCTGAATACATTTTCAGAGCCAAATTACAAGTGGGTGAAGACATGCTACAA CTACTATTTTTAGCAATGTTTTTAAATTTGTGTCTATTGGGGTGGGAAGGGGAGTGAGGCCCTAAAGATAGGAATTCACTGATAGCTGAA ATAGATACAAGCCTAGGAGCCCCAGCCCCCTTTTCTTGACCATATCACAAGTGATTGAAGCCCAGTGAATTAGTCGGTTAGAATTCGTTC TACAACATGATAGAACTTTTCTTACTAGCTTCAGAAATGCACATTGATTTGTGCTATGATGGGTGGTGTTTGTAACAATCACTGTTCTAT AGGCTTATGATCTGAGCAAAATGTGAACTTCAGTATGTTTACTATTGCTCTTACTTGAAAACTTTTTTTCAAAAAAAGCACAAATTAAAG TAGTAAATTCATATCCATAGATAGTTCATTCATTCAACAAATATTTACCAAGTTCCTAATATAAGTGAAGGACCACTTCTCATATTAGAT TACTAAGTCATTTGTATGAATATGTGTGGCAGTGAAGAGAACAGGTCTTTCAAAAAGCATTTGATTATTTTTTTTAAATACACTCTCTTA TTTTTCTACTTGTTTTTTTGTTAATCATAGCAGGATATGACAACTCTTATTTGAATTGATTTTTTCATCTAATGTAATAATGGAAGCCAA AGTATTCATATTTCTTAAGATAGCCCTAAATGTACTCTTGAACTTCTTACTGGAACAATGTTTGATACTCTAGTATGTAAGCTGTATTTA >In-frame_DCLK1_ENST00000255448_chr13_36445361_-_RCBTB1_ENST00000378302_chr13_50108398_-_3461nt GCACATCCCTGCACTAGTGGCCGCAACCGAGGCGCCGCGCTCCAGCAGCTGCTGCCGCCCAGCCCGGCCCCGCCGCCGCCCCCCAGCCCT GCAGCCCCGCAGCCCCGGCCGCGCCCAGCCCGGCGAGGACAGCACCAGGAGGCGGCCCCCAGCGCGGCCACAAAGACCCCCGGCGGCGTC TCTCCGCGGACCGGTCCTACTTGAAGTCCATCATGTCCTTCGGCAGAGACATGGAGCTGGAGCACTTCGACGAGCGGGATAAGGCGCAGA GATACAGCCGAGGGTCGCGGGTGAACGGCCTGCCGAGCCCGACGCACAGCGCCCACTGCAGCTTCTACCGCACCCGCACGCTGCAGACGC TCAGCTCCGAGAAGAAGGCCAAGAAAGTTCGTTTCTATCGAAACGGAGATCGATACTTCAAAGGGATTGTGTATGCCATCTCCCCAGACC GGTTCCGATCTTTTGAGGCCCTGCTGGCTGATTTGACCCGAACTCTGTCGGATAACGTGAATTTGCCCCAGGGAGTGAGAACAATCTACA CCATTGATGGGCTCAAGAAGATTTCCAGCCTGGACCAACTGGTGGAAGGAGAGAGTTATGTATGTGGCTCCATAGAGCCCTTCAAGAAAC TGGAGTACACCAAGAATGTGAACCCCAACTGGTCGGTGAACGTCAAGACCACCTCGGCTTCTCGGGCAGTGTCTTCACTGGCCACTGCCA AAGGAAGCCCTTCAGAGGTGCGAGAGAATAAGGATTTCATTCGGCCCAAGCTGGTCACCATCATCAGAAGTGGCGTGAAGCCACGGAAAG CTGTCAGGATTCTGCTGAACAAGAAAACGGCTCATTCCTTTGAGCAGGTCCTCACCGATATCACCGATGCCATCAAGCTGGACTCGGGAG TGGTGAAACGCCTGTACACGTTGGATGGGAAACAGGTGATGTGCCTTCAGGACTTTTTTGGTGATGATGACATTTTTATTGCATGTGGAC CGGAGAAGTTCCGTTACCAGGATGATTTCTTGCTAGATGAAAGTGAATGTCGAGTGGTAAAGTCCACTTCTTACACCAAAATAGCTTCAT CATCCCGCAGGAGCACCACCAAGAGCCCAGGACCGTCCAGGCGTAGCAAGTCCCCTGCCTCCACCAGCTCAGGATTTAGAAGAATTCTGC TTTAAGTTTTGCATCAATCATTTGACAGAAGTTACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATTGCT AAAGCCAGTAAATGTGGAGCCTTTAAGAACTGAAGCGCAAGGCTGCTGGGTTCTGTGTGAGTGCTCTGGGGCACTGTTGAGGATGTGTCC AGTTTGTGCTCTACGGGTGATGTGATTCTGCAGGTAAAAGACCATCAGGTTGTTTTTTTCCACATCTGGGACACAGTTGTTTGTGTAGGA ACATAACAAGGGTGTACGGCTTTTCTTGAGCCCATTTTAAACAACCCTTGTTTCCAGATAAGTGTATTTTAAATGTGACCTTTCGTAAAT TTGGGCTGGAACATGTAAAAGGGTGAAAGTTAGTCGTTTTTGGTCTTCTTTTCATTTTTGATTAGAGGAACTTCTGAACTTGGAAAGGGG AAGTTGGCAGCAACTCTCCTGGGCCACGTATCAACAATCTTCTGACAGCAGGAGCAGTGATAGTTGGGGAATTGTGAGATGAATGGAGAG GCCCCATCGTGAATTAAAGATGCTGACCTGGGGATTGTTAAGTGCTGCCTTAGTTGCTAGTTTAGTAGCCTTACTGTGAAGGAATAATTA AGATTGTTTCAGACTTTTGTTTGTGTGCTTGCGTTGATGACTTTTTTAACTTCAAGATAAATCAAAGTAATAAGTTTAACGTATATTAAA CCTGTTGAAATGATAATTATGTAAAGATAAATATTCTAGGTTAGTCAAGATTTCTCTTAAGATTTAAGTGCATAAAGAATAGTAATTTAG AAGTATCCGTGAAAAGTTGATAATGAAAGAAATTTGATGAAGGTGAATATTTTATAAATTAGAATCTCCACTACTTATCCAATGGTGTTT TATTTCATTAAGGTAGAACTTGAGAACTCAAGTTTAAATTGTCCCCCACCACCTTCTTCTATAAATGCAAACTTAAGAGGAAAATAATGA CATGTATAGTATACTCTTGCCTTCCTAAATTATGACTGCTGAATCATCATATCTACTATATATGACTGGAAGAAGTGGTTCTTCAAGTCA ACCCTCTTACAAGACTTAGTGGAATTTGCTTTATCTACTTTAGGCCAAATCCATCACACATTGGCTTATGTGAAACTTTATCATCTTTCA CTTTTGGTTTTCCTCTGTTTTTAAACATCTTAGGTATAACAGCACAATTTCACCTTGAAAAAGCACCAAAATTATGGTGTTCCTGAAAAG ATCCTATTAAAAGACAGTAGTTTATTTGAACTGGTTATGGAAGGTGACTTTGGGATGTAAGAGTGTTCAACTGTGAGTTTCATCATGTGT GTCCGTTGAGCTTGCTTTTAAGAGCAATGTTTTGCTTTGCTCTCTGGTCCATGAACTCATTTCCATTTGAGTGAGTTCCCTTAGTGAATT TTGTCTCCTGCTTGGAAAGTCTCTCTTCTGAACCTGGAGCCTGAATACATTTTCAGAGCCAAATTACAAGTGGGTGAAGACATGCTACAA CTACTATTTTTAGCAATGTTTTTAAATTTGTGTCTATTGGGGTGGGAAGGGGAGTGAGGCCCTAAAGATAGGAATTCACTGATAGCTGAA ATAGATACAAGCCTAGGAGCCCCAGCCCCCTTTTCTTGACCATATCACAAGTGATTGAAGCCCAGTGAATTAGTCGGTTAGAATTCGTTC TACAACATGATAGAACTTTTCTTACTAGCTTCAGAAATGCACATTGATTTGTGCTATGATGGGTGGTGTTTGTAACAATCACTGTTCTAT AGGCTTATGATCTGAGCAAAATGTGAACTTCAGTATGTTTACTATTGCTCTTACTTGAAAACTTTTTTTCAAAAAAAGCACAAATTAAAG TAGTAAATTCATATCCATAGATAGTTCATTCATTCAACAAATATTTACCAAGTTCCTAATATAAGTGAAGGACCACTTCTCATATTAGAT TACTAAGTCATTTGTATGAATATGTGTGGCAGTGAAGAGAACAGGTCTTTCAAAAAGCATTTGATTATTTTTTTTAAATACACTCTCTTA TTTTTCTACTTGTTTTTTTGTTAATCATAGCAGGATATGACAACTCTTATTTGAATTGATTTTTTCATCTAATGTAATAATGGAAGCCAA AGTATTCATATTTCTTAAGATAGCCCTAAATGTACTCTTGAACTTCTTACTGGAACAATGTTTGATACTCTAGTATGTAAGCTGTATTTA >In-frame_DCLK1_ENST00000379892_chr13_36445361_-_RCBTB1_ENST00000378302_chr13_50108398_-_3461nt GCACATCCCTGCACTAGTGGCCGCAACCGAGGCGCCGCGCTCCAGCAGCTGCTGCCGCCCAGCCCGGCCCCGCCGCCGCCCCCCAGCCCT GCAGCCCCGCAGCCCCGGCCGCGCCCAGCCCGGCGAGGACAGCACCAGGAGGCGGCCCCCAGCGCGGCCACAAAGACCCCCGGCGGCGTC TCTCCGCGGACCGGTCCTACTTGAAGTCCATCATGTCCTTCGGCAGAGACATGGAGCTGGAGCACTTCGACGAGCGGGATAAGGCGCAGA GATACAGCCGAGGGTCGCGGGTGAACGGCCTGCCGAGCCCGACGCACAGCGCCCACTGCAGCTTCTACCGCACCCGCACGCTGCAGACGC TCAGCTCCGAGAAGAAGGCCAAGAAAGTTCGTTTCTATCGAAACGGAGATCGATACTTCAAAGGGATTGTGTATGCCATCTCCCCAGACC GGTTCCGATCTTTTGAGGCCCTGCTGGCTGATTTGACCCGAACTCTGTCGGATAACGTGAATTTGCCCCAGGGAGTGAGAACAATCTACA CCATTGATGGGCTCAAGAAGATTTCCAGCCTGGACCAACTGGTGGAAGGAGAGAGTTATGTATGTGGCTCCATAGAGCCCTTCAAGAAAC TGGAGTACACCAAGAATGTGAACCCCAACTGGTCGGTGAACGTCAAGACCACCTCGGCTTCTCGGGCAGTGTCTTCACTGGCCACTGCCA AAGGAAGCCCTTCAGAGGTGCGAGAGAATAAGGATTTCATTCGGCCCAAGCTGGTCACCATCATCAGAAGTGGCGTGAAGCCACGGAAAG CTGTCAGGATTCTGCTGAACAAGAAAACGGCTCATTCCTTTGAGCAGGTCCTCACCGATATCACCGATGCCATCAAGCTGGACTCGGGAG TGGTGAAACGCCTGTACACGTTGGATGGGAAACAGGTGATGTGCCTTCAGGACTTTTTTGGTGATGATGACATTTTTATTGCATGTGGAC CGGAGAAGTTCCGTTACCAGGATGATTTCTTGCTAGATGAAAGTGAATGTCGAGTGGTAAAGTCCACTTCTTACACCAAAATAGCTTCAT CATCCCGCAGGAGCACCACCAAGAGCCCAGGACCGTCCAGGCGTAGCAAGTCCCCTGCCTCCACCAGCTCAGGATTTAGAAGAATTCTGC TTTAAGTTTTGCATCAATCATTTGACAGAAGTTACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATTGCT AAAGCCAGTAAATGTGGAGCCTTTAAGAACTGAAGCGCAAGGCTGCTGGGTTCTGTGTGAGTGCTCTGGGGCACTGTTGAGGATGTGTCC AGTTTGTGCTCTACGGGTGATGTGATTCTGCAGGTAAAAGACCATCAGGTTGTTTTTTTCCACATCTGGGACACAGTTGTTTGTGTAGGA ACATAACAAGGGTGTACGGCTTTTCTTGAGCCCATTTTAAACAACCCTTGTTTCCAGATAAGTGTATTTTAAATGTGACCTTTCGTAAAT TTGGGCTGGAACATGTAAAAGGGTGAAAGTTAGTCGTTTTTGGTCTTCTTTTCATTTTTGATTAGAGGAACTTCTGAACTTGGAAAGGGG AAGTTGGCAGCAACTCTCCTGGGCCACGTATCAACAATCTTCTGACAGCAGGAGCAGTGATAGTTGGGGAATTGTGAGATGAATGGAGAG GCCCCATCGTGAATTAAAGATGCTGACCTGGGGATTGTTAAGTGCTGCCTTAGTTGCTAGTTTAGTAGCCTTACTGTGAAGGAATAATTA AGATTGTTTCAGACTTTTGTTTGTGTGCTTGCGTTGATGACTTTTTTAACTTCAAGATAAATCAAAGTAATAAGTTTAACGTATATTAAA CCTGTTGAAATGATAATTATGTAAAGATAAATATTCTAGGTTAGTCAAGATTTCTCTTAAGATTTAAGTGCATAAAGAATAGTAATTTAG AAGTATCCGTGAAAAGTTGATAATGAAAGAAATTTGATGAAGGTGAATATTTTATAAATTAGAATCTCCACTACTTATCCAATGGTGTTT TATTTCATTAAGGTAGAACTTGAGAACTCAAGTTTAAATTGTCCCCCACCACCTTCTTCTATAAATGCAAACTTAAGAGGAAAATAATGA CATGTATAGTATACTCTTGCCTTCCTAAATTATGACTGCTGAATCATCATATCTACTATATATGACTGGAAGAAGTGGTTCTTCAAGTCA ACCCTCTTACAAGACTTAGTGGAATTTGCTTTATCTACTTTAGGCCAAATCCATCACACATTGGCTTATGTGAAACTTTATCATCTTTCA CTTTTGGTTTTCCTCTGTTTTTAAACATCTTAGGTATAACAGCACAATTTCACCTTGAAAAAGCACCAAAATTATGGTGTTCCTGAAAAG ATCCTATTAAAAGACAGTAGTTTATTTGAACTGGTTATGGAAGGTGACTTTGGGATGTAAGAGTGTTCAACTGTGAGTTTCATCATGTGT GTCCGTTGAGCTTGCTTTTAAGAGCAATGTTTTGCTTTGCTCTCTGGTCCATGAACTCATTTCCATTTGAGTGAGTTCCCTTAGTGAATT TTGTCTCCTGCTTGGAAAGTCTCTCTTCTGAACCTGGAGCCTGAATACATTTTCAGAGCCAAATTACAAGTGGGTGAAGACATGCTACAA CTACTATTTTTAGCAATGTTTTTAAATTTGTGTCTATTGGGGTGGGAAGGGGAGTGAGGCCCTAAAGATAGGAATTCACTGATAGCTGAA ATAGATACAAGCCTAGGAGCCCCAGCCCCCTTTTCTTGACCATATCACAAGTGATTGAAGCCCAGTGAATTAGTCGGTTAGAATTCGTTC TACAACATGATAGAACTTTTCTTACTAGCTTCAGAAATGCACATTGATTTGTGCTATGATGGGTGGTGTTTGTAACAATCACTGTTCTAT AGGCTTATGATCTGAGCAAAATGTGAACTTCAGTATGTTTACTATTGCTCTTACTTGAAAACTTTTTTTCAAAAAAAGCACAAATTAAAG TAGTAAATTCATATCCATAGATAGTTCATTCATTCAACAAATATTTACCAAGTTCCTAATATAAGTGAAGGACCACTTCTCATATTAGAT TACTAAGTCATTTGTATGAATATGTGTGGCAGTGAAGAGAACAGGTCTTTCAAAAAGCATTTGATTATTTTTTTTAAATACACTCTCTTA TTTTTCTACTTGTTTTTTTGTTAATCATAGCAGGATATGACAACTCTTATTTGAATTGATTTTTTCATCTAATGTAATAATGGAAGCCAA AGTATTCATATTTCTTAAGATAGCCCTAAATGTACTCTTGAACTTCTTACTGGAACAATGTTTGATACTCTAGTATGTAAGCTGTATTTA |
Top |
FusionGenePPI for DCLK1_RCBTB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DCLK1 | APP, CFTR, HAX1, NUFIP1, CDCA8, DGUOK, DNAAF2, DCX, SLC4A1AP, CEP170, SPICE1, CEP128, DCTN1, LCA5, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, ZNF638, SRSF12, SYDE1, RTKN, MAST3, PPM1H, AGAP1, CDC25B, CDK16, DENND4C, FAM110B, USP21, FAM53C, ANKRD34A, MAPKAP1, FAM110A, CGN, HDAC4, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, CAMSAP2, MELK, PLEKHA7, CDC25C, LPIN3, KIF1C, GIGYF2, DEPDC1B, NAV1, MLLT4, DENND4A, PTPN14, STARD13, RPTOR, PLEKHA5, SH3BP4, HDAC7, EDC3, SH3RF3, LARP1, RAB3IP, INPP5E | RCBTB1 | CUL3, CUL5, CUL2, CUL1, COPS5, UBE2E3, APP, HSP90AA1, ANKRD40, HERC3, HELZ, FOXR2, RCBTB2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DCLK1_RCBTB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DCLK1_RCBTB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DCLK1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | DCLK1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | DCLK1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | RCBTB1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|