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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9418

FusionGeneSummary for DCLK1_CLDN10

check button Fusion gene summary
Fusion gene informationFusion gene name: DCLK1_CLDN10
Fusion gene ID: 9418
HgeneTgene
Gene symbol

DCLK1

CLDN10

Gene ID

9201

9071

Gene namedoublecortin like kinase 1claudin 10
SynonymsCL1|CLICK1|DCAMKL1|DCDC3A|DCLKCPETRL3|HELIX|OSP-L|OSPL
Cytomap

13q13.3

13q32.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1claudin-10OSP-like proteinoligodendrocyte-specific protein-like
Modification date2018052720180519
UniProtAcc

O15075

P78369

Ensembl transtripts involved in fusion geneENST00000360631, ENST00000255448, 
ENST00000379892, ENST00000379893, 
ENST00000460982, 
ENST00000376873, 
ENST00000299339, ENST00000376855, 
Fusion gene scores* DoF score4 X 3 X 3=364 X 2 X 5=40
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DCLK1 [Title/Abstract] AND CLDN10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A8BV-01ADCLK1chr13

36686006

-CLDN10chr13

96212386

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000360631ENST00000376873DCLK1chr13

36686006

-CLDN10chr13

96212386

+
Frame-shitENST00000360631ENST00000299339DCLK1chr13

36686006

-CLDN10chr13

96212386

+
5CDS-intronENST00000360631ENST00000376855DCLK1chr13

36686006

-CLDN10chr13

96212386

+
Frame-shitENST00000255448ENST00000376873DCLK1chr13

36686006

-CLDN10chr13

96212386

+
Frame-shitENST00000255448ENST00000299339DCLK1chr13

36686006

-CLDN10chr13

96212386

+
5CDS-intronENST00000255448ENST00000376855DCLK1chr13

36686006

-CLDN10chr13

96212386

+
Frame-shitENST00000379892ENST00000376873DCLK1chr13

36686006

-CLDN10chr13

96212386

+
Frame-shitENST00000379892ENST00000299339DCLK1chr13

36686006

-CLDN10chr13

96212386

+
5CDS-intronENST00000379892ENST00000376855DCLK1chr13

36686006

-CLDN10chr13

96212386

+
intron-3CDSENST00000379893ENST00000376873DCLK1chr13

36686006

-CLDN10chr13

96212386

+
intron-3CDSENST00000379893ENST00000299339DCLK1chr13

36686006

-CLDN10chr13

96212386

+
intron-intronENST00000379893ENST00000376855DCLK1chr13

36686006

-CLDN10chr13

96212386

+
intron-3CDSENST00000460982ENST00000376873DCLK1chr13

36686006

-CLDN10chr13

96212386

+
intron-3CDSENST00000460982ENST00000299339DCLK1chr13

36686006

-CLDN10chr13

96212386

+
intron-intronENST00000460982ENST00000376855DCLK1chr13

36686006

-CLDN10chr13

96212386

+

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FusionProtFeatures for DCLK1_CLDN10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCLK1

O15075

CLDN10

P78369

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developingbrain. May also participate in functions of the mature nervoussystem. Plays a major role in tight junction-specificobliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation ofparacellular epithelia permeability to ions in multiple organs. Itacts as a paracellular ion channel probably forming permselectivepores; isoform 1 appears to create pores preferentially permeableto cations and isoform 2 for anions. In sweat glands and in thethick ascending limb (TAL) of Henle's loop in kidney, it controlsparacellular sodium permeability which is essential for propersweat production and renal function (PubMed:19383724,PubMed:28771254, PubMed:28686597). {ECO:0000269|PubMed:19383724,ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCLK1_CLDN10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCLK1_CLDN10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCLK1APP, CFTR, HAX1, NUFIP1, CDCA8, DGUOK, DNAAF2, DCX, SLC4A1AP, CEP170, SPICE1, CEP128, DCTN1, LCA5, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, ZNF638, SRSF12, SYDE1, RTKN, MAST3, PPM1H, AGAP1, CDC25B, CDK16, DENND4C, FAM110B, USP21, FAM53C, ANKRD34A, MAPKAP1, FAM110A, CGN, HDAC4, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, CAMSAP2, MELK, PLEKHA7, CDC25C, LPIN3, KIF1C, GIGYF2, DEPDC1B, NAV1, MLLT4, DENND4A, PTPN14, STARD13, RPTOR, PLEKHA5, SH3BP4, HDAC7, EDC3, SH3RF3, LARP1, RAB3IP, INPP5ECLDN10VKORC1, ATE1, FGF1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCLK1_CLDN10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCLK1_CLDN10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCLK1C0005586Bipolar Disorder1PSYGENET
HgeneDCLK1C0009404Colorectal Neoplasms1CTD_human
HgeneDCLK1C0036341Schizophrenia1PSYGENET