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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9396

FusionGeneSummary for DCAKD_ADAMTS7

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAKD_ADAMTS7
Fusion gene ID: 9396
HgeneTgene
Gene symbol

DCAKD

ADAMTS7

Gene ID

79877

11173

Gene namedephospho-CoA kinase domain containingADAM metallopeptidase with thrombospondin type 1 motif 7
Synonyms-ADAM-TS 7|ADAM-TS7|ADAMTS-7
Cytomap

17q21.31

15q25.1

Type of geneprotein-codingprotein-coding
Descriptiondephospho-CoA kinase domain-containing proteinA disintegrin and metalloproteinase with thrombospondin motifs 7COMPasea disintegrin and metalloprotease with thrombospondin motifs-7 preproproteina disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7
Modification date2018052320180522
UniProtAcc

Q8WVC6

Q9UKP4

Ensembl transtripts involved in fusion geneENST00000342350, ENST00000588499, 
ENST00000588295, ENST00000310604, 
ENST00000452796, 
ENST00000388820, 
ENST00000566303, 
Fusion gene scores* DoF score7 X 5 X 6=2101 X 1 X 1=1
# samples 81
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DCAKD [Title/Abstract] AND ADAMTS7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADAMTS7

GO:0032331

negative regulation of chondrocyte differentiation

22247065

TgeneADAMTS7

GO:0071773

cellular response to BMP stimulus

22247065


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPCPGTCGA-QR-A6GS-01ADCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
TCGALDPCPGTCGA-QR-A6GS-01ADCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000342350ENST00000388820DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
intron-5UTRENST00000342350ENST00000566303DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
5UTR-3CDSENST00000588499ENST00000388820DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
5UTR-5UTRENST00000588499ENST00000566303DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
5UTR-3CDSENST00000588295ENST00000388820DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
5UTR-5UTRENST00000588295ENST00000566303DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
intron-3CDSENST00000310604ENST00000388820DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
intron-5UTRENST00000310604ENST00000566303DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
intron-3CDSENST00000452796ENST00000388820DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
intron-5UTRENST00000452796ENST00000566303DCAKDchr17

43128921

-ADAMTS7chr15

79083565

-
5UTR-3CDSENST00000342350ENST00000388820DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
5UTR-5UTRENST00000342350ENST00000566303DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
intron-3CDSENST00000588499ENST00000388820DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
intron-5UTRENST00000588499ENST00000566303DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
intron-3CDSENST00000588295ENST00000388820DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
intron-5UTRENST00000588295ENST00000566303DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
5UTR-3CDSENST00000310604ENST00000388820DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
5UTR-5UTRENST00000310604ENST00000566303DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
intron-3CDSENST00000452796ENST00000388820DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-
intron-5UTRENST00000452796ENST00000566303DCAKDchr17

43138256

-ADAMTS7chr15

79083565

-

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FusionProtFeatures for DCAKD_ADAMTS7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAKD

Q8WVC6

ADAMTS7

Q9UKP4

Metalloprotease that may play a role in the degradationof COMP. {ECO:0000269|PubMed:16585064}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCAKD_ADAMTS7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCAKD_ADAMTS7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCAKDUBC, ELAVL1, SRPRB, MCOLN3, DLK1, FAM189A2, FOXS1, MCM2, COQ9, PTPN5, DUSP22, IMPDH1, TMPRSS3, TMEM9B, UST, APBB1, IL4R, GPR114, HCCS, COMT, RDH11, ESYT1, TMX1ADAMTS7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCAKD_ADAMTS7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCAKD_ADAMTS7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADAMTS7C0032460Polycystic Ovary Syndrome1CTD_human
TgeneADAMTS7C1956346Coronary Artery Disease1CTD_human