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Fusion gene ID: 9396 |
FusionGeneSummary for DCAKD_ADAMTS7 |
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Fusion gene information | Fusion gene name: DCAKD_ADAMTS7 | Fusion gene ID: 9396 | Hgene | Tgene | Gene symbol | DCAKD | ADAMTS7 | Gene ID | 79877 | 11173 |
Gene name | dephospho-CoA kinase domain containing | ADAM metallopeptidase with thrombospondin type 1 motif 7 | |
Synonyms | - | ADAM-TS 7|ADAM-TS7|ADAMTS-7 | |
Cytomap | 17q21.31 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | dephospho-CoA kinase domain-containing protein | A disintegrin and metalloproteinase with thrombospondin motifs 7COMPasea disintegrin and metalloprotease with thrombospondin motifs-7 preproproteina disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q8WVC6 | Q9UKP4 | |
Ensembl transtripts involved in fusion gene | ENST00000342350, ENST00000588499, ENST00000588295, ENST00000310604, ENST00000452796, | ENST00000388820, ENST00000566303, | |
Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 1 X 1 X 1=1 |
# samples | 8 | 1 | |
** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DCAKD [Title/Abstract] AND ADAMTS7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ADAMTS7 | GO:0032331 | negative regulation of chondrocyte differentiation | 22247065 |
Tgene | ADAMTS7 | GO:0071773 | cellular response to BMP stimulus | 22247065 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PCPG | TCGA-QR-A6GS-01A | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
TCGA | LD | PCPG | TCGA-QR-A6GS-01A | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000342350 | ENST00000388820 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-5UTR | ENST00000342350 | ENST00000566303 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
5UTR-3CDS | ENST00000588499 | ENST00000388820 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
5UTR-5UTR | ENST00000588499 | ENST00000566303 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
5UTR-3CDS | ENST00000588295 | ENST00000388820 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
5UTR-5UTR | ENST00000588295 | ENST00000566303 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-3CDS | ENST00000310604 | ENST00000388820 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-5UTR | ENST00000310604 | ENST00000566303 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-3CDS | ENST00000452796 | ENST00000388820 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-5UTR | ENST00000452796 | ENST00000566303 | DCAKD | chr17 | 43128921 | - | ADAMTS7 | chr15 | 79083565 | - |
5UTR-3CDS | ENST00000342350 | ENST00000388820 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
5UTR-5UTR | ENST00000342350 | ENST00000566303 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-3CDS | ENST00000588499 | ENST00000388820 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-5UTR | ENST00000588499 | ENST00000566303 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-3CDS | ENST00000588295 | ENST00000388820 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-5UTR | ENST00000588295 | ENST00000566303 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
5UTR-3CDS | ENST00000310604 | ENST00000388820 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
5UTR-5UTR | ENST00000310604 | ENST00000566303 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-3CDS | ENST00000452796 | ENST00000388820 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
intron-5UTR | ENST00000452796 | ENST00000566303 | DCAKD | chr17 | 43138256 | - | ADAMTS7 | chr15 | 79083565 | - |
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FusionProtFeatures for DCAKD_ADAMTS7 |
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Hgene | Tgene |
DCAKD | ADAMTS7 |
Metalloprotease that may play a role in the degradationof COMP. {ECO:0000269|PubMed:16585064}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DCAKD_ADAMTS7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DCAKD_ADAMTS7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DCAKD | UBC, ELAVL1, SRPRB, MCOLN3, DLK1, FAM189A2, FOXS1, MCM2, COQ9, PTPN5, DUSP22, IMPDH1, TMPRSS3, TMEM9B, UST, APBB1, IL4R, GPR114, HCCS, COMT, RDH11, ESYT1, TMX1 | ADAMTS7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DCAKD_ADAMTS7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCAKD_ADAMTS7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ADAMTS7 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | ADAMTS7 | C1956346 | Coronary Artery Disease | 1 | CTD_human |