![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 939 |
FusionGeneSummary for ADPRHL1_TFDP1 |
![]() |
Fusion gene information | Fusion gene name: ADPRHL1_TFDP1 | Fusion gene ID: 939 | Hgene | Tgene | Gene symbol | ADPRHL1 | TFDP1 | Gene ID | 113622 | 7027 |
Gene name | ADP-ribosylhydrolase like 1 | transcription factor Dp-1 | |
Synonyms | ARH2 | DILC|DP1|DRTF1|Dp-1 | |
Cytomap | 13q34 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | [Protein ADP-ribosylarginine] hydrolase-like protein 1ADP-ribosyl-hydrolaseADP-ribosylarginine hydrolase like 1ADP-ribosylhydrolase 2 | transcription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q8NDY3 | Q14186 | |
Ensembl transtripts involved in fusion gene | ENST00000356501, ENST00000375418, | ENST00000375370, ENST00000538138, ENST00000465174, ENST00000544902, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 4 X 6=144 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADPRHL1 [Title/Abstract] AND TFDP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TFDP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7739537 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-55-8620-01A | ADPRHL1 | chr13 | 114062271 | - | TFDP1 | chr13 | 114240089 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000356501 | ENST00000375370 | ADPRHL1 | chr13 | 114062271 | - | TFDP1 | chr13 | 114240089 | + |
intron-5UTR | ENST00000356501 | ENST00000538138 | ADPRHL1 | chr13 | 114062271 | - | TFDP1 | chr13 | 114240089 | + |
intron-3UTR | ENST00000356501 | ENST00000465174 | ADPRHL1 | chr13 | 114062271 | - | TFDP1 | chr13 | 114240089 | + |
intron-5UTR | ENST00000356501 | ENST00000544902 | ADPRHL1 | chr13 | 114062271 | - | TFDP1 | chr13 | 114240089 | + |
intron-5UTR | ENST00000375418 | ENST00000375370 | ADPRHL1 | chr13 | 114062271 | - | TFDP1 | chr13 | 114240089 | + |
intron-5UTR | ENST00000375418 | ENST00000538138 | ADPRHL1 | chr13 | 114062271 | - | TFDP1 | chr13 | 114240089 | + |
intron-3UTR | ENST00000375418 | ENST00000465174 | ADPRHL1 | chr13 | 114062271 | - | TFDP1 | chr13 | 114240089 | + |
intron-5UTR | ENST00000375418 | ENST00000544902 | ADPRHL1 | chr13 | 114062271 | - | TFDP1 | chr13 | 114240089 | + |
Top |
FusionProtFeatures for ADPRHL1_TFDP1 |
![]() |
Hgene | Tgene |
ADPRHL1 | TFDP1 |
Can stimulate E2F-dependent transcription. Binds DNAcooperatively with E2F family members through the E2 recognitionsite, 5'-TTTC[CG]CGC-3', found in the promoter region of a numberof genes whose products are involved in cell cycle regulation orin DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DPcomplex appears to mediate both cell proliferation and apoptosis.Blocks adipocyte differentiation by repressing CEBPA binding toits target gene promoters (PubMed:20176812).{ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537,ECO:0000269|PubMed:8405995}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ADPRHL1_TFDP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ADPRHL1_TFDP1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADPRHL1 | TFDP1 | E2F6, E2F5, TP53BP1, TP53, NPDC1, CDK3, E2F1, E2F4, RB1, RBL1, RBL2, LIN9, LIN37, LIN54, ELAVL1, PCGF6, RNF2, RYBP, YAF2, SOCS3, CDK2, CDK1, PRPF31, E2F2, E2F3, CDK6, SIAH1, CREBBP, CDC20, CDC27, ANAPC5, MIER2, COMMD4, CDT1, MAX, L3MBTL2, GGA1, COMMD8, COMMD1, GMNN, COMMD6, HDAC1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ADPRHL1_TFDP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ADPRHL1_TFDP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TFDP1 | C3495559 | Juvenile arthritis | 1 | CTD_human |