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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 9376

FusionGeneSummary for DCAF6_LETM1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF6_LETM1
Fusion gene ID: 9376
HgeneTgene
Gene symbol

DCAF6

LETM1

Gene ID

55827

3954

Gene nameDDB1 and CUL4 associated factor 6leucine zipper and EF-hand containing transmembrane protein 1
Synonyms1200006M05Rik|ARCAP|IQWD1|MSTP055|NRIP|PC326SLC55A1
Cytomap

1q24.2

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 6IQ motif and WD repeat-containing protein 1IQ motif and WD repeats 1androgen receptor complex-associated proteinnuclear receptor interaction proteinmitochondrial proton/calcium exchanger proteinLETM1 and EF-hand domain-containing protein 1, mitochondrialMdm38 homologleucine zipper-EF-hand containing transmembrane protein 1
Modification date2018051920180523
UniProtAcc

Q58WW2

O95202

Ensembl transtripts involved in fusion geneENST00000367843, ENST00000432587, 
ENST00000312263, ENST00000367840, 
ENST00000470919, 		ENST00000302787, 
ENST00000512189, 
Fusion gene scores* DoF score11 X 6 X 6=3963 X 3 X 3=27
# samples 124
** MAII scorelog2(12/396*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DCAF6 [Title/Abstract] AND LETM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLETM1

GO:0006851

mitochondrial calcium ion transmembrane transport

19797662

TgeneLETM1

GO:0051560

mitochondrial calcium ion homeostasis

19797662

TgeneLETM1

GO:0099093

calcium export from the mitochondrion

19797662


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-1497-01ADCAF6chr1

167906246

+LETM1chr4

1850936

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367843ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
5CDS-5UTRENST00000367843ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-
In-frameENST00000432587ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
5CDS-5UTRENST00000432587ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-
In-frameENST00000312263ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
5CDS-5UTRENST00000312263ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-
In-frameENST00000367840ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
5CDS-5UTRENST00000367840ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-
intron-3CDSENST00000470919ENST00000302787DCAF6chr1

167906246

+LETM1chr4

1850936

-
intron-5UTRENST00000470919ENST00000512189DCAF6chr1

167906246

+LETM1chr4

1850936

-

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FusionProtFeatures for DCAF6_LETM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF6

Q58WW2

LETM1

O95202

Ligand-dependent coactivator of nuclear receptors.Enhance transcriptional activity of the nuclear receptors NR3C1and AR. May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617,ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. Mitochondrial proton/calcium antiporter that mediatesproton-dependent calcium efflux from mitochondrion(PubMed:19797662). Crucial for the maintenance of mitochondrialtubular networks and for the assembly of the supercomplexes of therespiratory chain (PubMed:18628306). Required for the maintenanceof the tubular shape and cristae organization (PubMed:18628306).In contrast to SLC8B1/NCLX, does not constitute the major factorfor mitochondrial calcium extrusion (PubMed:24898248).{ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:19797662,ECO:0000269|PubMed:24898248}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014676_68827740Calcium bindingOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014115_13627740Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014462_49027740Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014537_62727740Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014708_73927740Coiled coilOntology_term=ECO:0000255
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014252_53727740DomainLetm1 RBD
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014663_69827740DomainEF-hand
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014116_20827740Topological domainMitochondrial intermembrane
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014230_73927740Topological domainMitochondrial matrix
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-014209_22927740TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119676_70532861DomainIQ
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122676_70532952DomainIQ
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120676_70532881DomainIQ
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121676_70532921DomainIQ
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119139_17932861RepeatNote=WD 3
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119189_22932861RepeatNote=WD 4
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119251_29032861RepeatNote=WD 5
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+11949_8832861RepeatNote=WD 1
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119718_75632861RepeatNote=WD 6
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+119759_79832861RepeatNote=WD 7
HgeneDCAF6chr1:167906246chr4:1850936ENST00000312263+11992_13332861RepeatNote=WD 2
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122139_17932952RepeatNote=WD 3
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122189_22932952RepeatNote=WD 4
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122251_29032952RepeatNote=WD 5
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+12249_8832952RepeatNote=WD 1
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122718_75632952RepeatNote=WD 6
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+122759_79832952RepeatNote=WD 7
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367840+12292_13332952RepeatNote=WD 2
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120139_17932881RepeatNote=WD 3
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120189_22932881RepeatNote=WD 4
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120251_29032881RepeatNote=WD 5
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+12049_8832881RepeatNote=WD 1
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120718_75632881RepeatNote=WD 6
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+120759_79832881RepeatNote=WD 7
HgeneDCAF6chr1:167906246chr4:1850936ENST00000367843+12092_13332881RepeatNote=WD 2
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121139_17932921RepeatNote=WD 3
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121189_22932921RepeatNote=WD 4
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121251_29032921RepeatNote=WD 5
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+12149_8832921RepeatNote=WD 1
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121718_75632921RepeatNote=WD 6
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+121759_79832921RepeatNote=WD 7
HgeneDCAF6chr1:167906246chr4:1850936ENST00000432587+12192_13332921RepeatNote=WD 2
TgeneLETM1chr1:167906246chr4:1850936ENST00000302787-01418_2127740Compositional biasNote=Poly-Pro


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FusionGeneSequence for DCAF6_LETM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DCAF6_ENST00000367843_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_745aa
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSR
APWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDT
KIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQ
DTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSI
KADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVA
KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL
KEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQ
LEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE

>In-frame_DCAF6_ENST00000432587_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_745aa
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSR
APWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDT
KIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQ
DTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSI
KADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVA
KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL
KEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQ
LEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE

>In-frame_DCAF6_ENST00000312263_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_745aa
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSR
APWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDT
KIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQ
DTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSI
KADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVA
KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL
KEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQ
LEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE

>In-frame_DCAF6_ENST00000367840_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_745aa
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSR
APWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDT
KIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQ
DTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSI
KADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVA
KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL
KEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQ
LEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DCAF6_ENST00000367843_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_2235nt
ATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAGGACCCGTCCCGGCTGCGGAGTCGA
TACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCATTTGGCTGCTGC
ACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGCATAGTGTCGAGA
GCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCGCGCCCTGTTCGC
GATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTACAGCCCCCCCGCA
GAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTATGGATCGACACC
AAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGGATCTGCGCTGAC
CTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTCTTCCCCAACATG
TTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAG
GACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAGAAGATCCGGGAA
ACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTGACACGGCCGCAG
CTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGGCTGCGCTCCATA
AAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCACGAGGCATGCGG
GCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCCACATCGCTGCTC
ATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCAGAGATTGTGGCA
AAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAGGAGGAGGCGGCC
ATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCCGAACGTGTGGTAGCTGCTCCCCAA
AGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGACACTGCCCCGGTGCTGGAGGGCTTG
AAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAGCAGAAGAAGTCACTCACCAAGGAG
AAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAGAAGGAACTTTCAAAGACTGGTGAA
GAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGGCAGATCGATGGCTTGATCTCGCAG
CTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTCATCAGTGTCGCTGAGCTCATCAAC
GCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAAAACAAGGATGGCAAGGTCAACATC
GACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTGGCTGAGATTGTAGCAACACTGGAA

>In-frame_DCAF6_ENST00000432587_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_2235nt
ATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAGGACCCGTCCCGGCTGCGGAGTCGA
TACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCATTTGGCTGCTGC
ACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGCATAGTGTCGAGA
GCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCGCGCCCTGTTCGC
GATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTACAGCCCCCCCGCA
GAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTATGGATCGACACC
AAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGGATCTGCGCTGAC
CTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTCTTCCCCAACATG
TTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAG
GACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAGAAGATCCGGGAA
ACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTGACACGGCCGCAG
CTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGGCTGCGCTCCATA
AAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCACGAGGCATGCGG
GCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCCACATCGCTGCTC
ATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCAGAGATTGTGGCA
AAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAGGAGGAGGCGGCC
ATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCCGAACGTGTGGTAGCTGCTCCCCAA
AGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGACACTGCCCCGGTGCTGGAGGGCTTG
AAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAGCAGAAGAAGTCACTCACCAAGGAG
AAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAGAAGGAACTTTCAAAGACTGGTGAA
GAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGGCAGATCGATGGCTTGATCTCGCAG
CTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTCATCAGTGTCGCTGAGCTCATCAAC
GCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAAAACAAGGATGGCAAGGTCAACATC
GACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTGGCTGAGATTGTAGCAACACTGGAA

>In-frame_DCAF6_ENST00000312263_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_2235nt
ATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAGGACCCGTCCCGGCTGCGGAGTCGA
TACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCATTTGGCTGCTGC
ACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGCATAGTGTCGAGA
GCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCGCGCCCTGTTCGC
GATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTACAGCCCCCCCGCA
GAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTATGGATCGACACC
AAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGGATCTGCGCTGAC
CTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTCTTCCCCAACATG
TTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAG
GACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAGAAGATCCGGGAA
ACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTGACACGGCCGCAG
CTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGGCTGCGCTCCATA
AAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCACGAGGCATGCGG
GCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCCACATCGCTGCTC
ATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCAGAGATTGTGGCA
AAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAGGAGGAGGCGGCC
ATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCCGAACGTGTGGTAGCTGCTCCCCAA
AGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGACACTGCCCCGGTGCTGGAGGGCTTG
AAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAGCAGAAGAAGTCACTCACCAAGGAG
AAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAGAAGGAACTTTCAAAGACTGGTGAA
GAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGGCAGATCGATGGCTTGATCTCGCAG
CTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTCATCAGTGTCGCTGAGCTCATCAAC
GCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAAAACAAGGATGGCAAGGTCAACATC
GACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTGGCTGAGATTGTAGCAACACTGGAA

>In-frame_DCAF6_ENST00000367840_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_2235nt
ATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAGGACCCGTCCCGGCTGCGGAGTCGA
TACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCATTTGGCTGCTGC
ACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGCATAGTGTCGAGA
GCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCGCGCCCTGTTCGC
GATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTACAGCCCCCCCGCA
GAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTATGGATCGACACC
AAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGGATCTGCGCTGAC
CTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTCTTCCCCAACATG
TTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAG
GACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAGAAGATCCGGGAA
ACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTGACACGGCCGCAG
CTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGGCTGCGCTCCATA
AAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCACGAGGCATGCGG
GCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCCACATCGCTGCTC
ATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCAGAGATTGTGGCA
AAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAGGAGGAGGCGGCC
ATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCCGAACGTGTGGTAGCTGCTCCCCAA
AGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGACACTGCCCCGGTGCTGGAGGGCTTG
AAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAGCAGAAGAAGTCACTCACCAAGGAG
AAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAGAAGGAACTTTCAAAGACTGGTGAA
GAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGGCAGATCGATGGCTTGATCTCGCAG
CTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTCATCAGTGTCGCTGAGCTCATCAAC
GCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAAAACAAGGATGGCAAGGTCAACATC
GACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTGGCTGAGATTGTAGCAACACTGGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_DCAF6_ENST00000367843_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_5431nt
GAGGAGACTGTTGCTGATCTTTGGATGTTCTGGTTAGTCTAAGAAGGAGAGTATGAGGCGAGCTCCGGCCCGGGTGCGGCCGGGCTTCAG
GGGCCCAGGCGCCGCTGCTGCCACCGCCATCTAACGCTGCGCCCTGGAGGCCCGGCGCGCGGATGGTGCCGGTGCGGCTCGGGTGTTGAA
ACGGGTGTCCCCTCCCCCTCCTCCCCTCCCCCACGCGGTGGTCTCCCCTCCCACCCGGCTCAGGCAGAGCCATGTCTCGGGGTGGCTCCT
ACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAGGACCCGTCCCGGCTGCGGAGTCGATACCTGGGTAGTCCAGGGG
ATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCATTTGGCTGCTGCACTCCCATCCACCCTGTGT
ACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGCATAGTGTCGAGAGCGCCATGGACCTCTACCT
CTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCGCGCCCTGTTCGCGATGACTCGGTAGTAGAGA
AGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTACAGCCCCCCCGCAGAGGTGGTGGTGAAGAAGT
CCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTATGGATCGACACCAAGATCGCGGCACGCATGC
TCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGGATCTGCGCTGACCTCTTCCGCCTGGTGCCGT
TCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTCTTCCCCAACATGTTGCCATCCACATTTGAGA
CTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAGGACACCATCGAGGAGATGG
CCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAGAAGATCCGGGAAACAGGGGAGAGGCCCAGCA
ATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTGACACGGCCGCAGCTGGTGGCCCTGTGCAAGC
TGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGGCTGCGCTCCATAAAGGCAGACGACAAGCTGA
TTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCACGAGGCATGCGGGCCCTGGGCGTCACGGAAG
ACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCCACATCGCTGCTCATCCTGTCCCGGGCCATGT
ACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCAGAGATTGTGGCAAAGGAAGCACAGGTGAAAG
TGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAGGAGGAGGCGGCCATCCAGCAGGAGCACCGTG
AGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCCGAACGTGTGGTAGCTGCTCCCCAAAGGCCGGGGACCGAGCCAC
AGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGACACTGCCCCGGTGCTGGAGGGCTTGAAGGAGGAAGAGATCACGA
AGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAGCAGAAGAAGTCACTCACCAAGGAGAAGGAGGAGCTGGAGCTGC
TGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAGAAGGAACTTTCAAAGACTGGTGAAGAAAAGTACGTGGAAGAAT
CTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGGCAGATCGATGGCTTGATCTCGCAGCTGGAGATGGACCAGCAGG
CTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTCATCAGTGTCGCTGAGCTCATCAACGCCATGAAGCAAGTCAAGC
ACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAAAACAAGGATGGCAAGGTCAACATCGACGACCTCGTCAAGGTGA
TTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTGGCTGAGATTGTAGCAACACTGGAAAAAGAGGAGAAGGTGGAGG
AGAAGGAGAAGGCCAAAGAGAAGGCAGAGAAGGAGGTCGCAGAGGTGAAGAGCTAGAACCACTGGCCTGGGCACCTGTCCTCCTGCTGTG
CCGTCACCCTGGCAAGGGCCGTGAGGGCGATTGCTTTGTGGTGATTCTCAGTGGCTCATCTAATATTTTGGCTGGAATAAATCAGAGACT
TCCATAATCAAGTAAATTTTAATTTTCATCATTCCACGGAGATTCAGTCTGTCTGGAATCCCGGAACCCCTCCACAGAATCGTGTCTGGA
TCCACACTGTGGTGTGGCTGCCACGGCCTCCTGGCTCCAGAGGCAGCTGGGCTGGGCCAAGGCAGGAAGGCGCCCCCATGTGTGTGGCCT
CAGTCTCAGCATCTGACTGTGCTGCCCTGTCCCCAGGGAAGAGAATGAGGACCACGTGGACTCCGCCCACACAGAGCTGGCTGCTGTGCC
CACCCTCAGGGGCGTCAGGAGACACAGCCTGGCCTCCTCAGGGCTGAAGATGCCTCCATTCGCCTGTGGACCTTGATTTCTAGATTTCAG
TGTCAATAGACCTGTCTTCCTGCACACTTTCAGTTGGATGTGGGTCATTGTGGAGACAGAGGTGTCTGCCATCTCTGTGGCCTCTGGAGA
GTGACGTCTCCCTGCTGGGAGTGCTGGTTCTCACGTGCGGTTTCCCTTGTGTATCGGAGCTCTTTCTCGGCTTTCTATTTCCCCCAGTTC
TTTAAGCAGTCAATTGGCACAGAGTTTCCCACGGGGGCTGCAGTGGATTCACTGTGTCAGGGATGAGCCTGGCTTGGGGGTTGGTGGGGC
TCTGAAGCGCATTTGGGGTTCTTTGTAGCTTCTAATGTGAGGTTTGAGTCCAGTGCGCCCACAGCAGCATGCCCTTCTCACCCCTTGCAG
TGTTGCAGGCTCAGGCCCCTGGGCTCCTTCAGCAAGCAGGCTAGTCAATGAGGCATGAGGATCCGGCACAGGGCATCCCCTGGGGCTTCA
AGGGCAATACCCCCGTGCTTAGGGTTTGCCCTGTGCCCTCTGGGTGGGGTGGCCTCCCCGCACTCGGCAGCATGGCCAGGCTGGCCAGGG
CGTGGGCAGGTGGTGTCCTGTGGCACCTCCATCCTCCTGCCCAGCCGGCTGTGTCACACTCATCTTTTTAAGGTCAGGTTGGTTCCTGGC
AAAAATGTACCTCCAGGGGCCTCCAAGCATAGGATTTGGAAGACAGGAACGGCACAGGCGTCCAGGAAAGCAGCTGCACTCAGACAATGC
CTTCTCCATTACTTGAAGCTTCTTTCTGTTCAGCCATTAAAGAAACTTGACAAAATAGGAACAGGAGATATTTCTCAATTGTAAACCTTT
GTGCAGGGACAGTTGGCTTCCAGAGGCTTTCAGCTTTCAGTTATTTGAGAAGTTTGTTTTAGATCCTTAACTAATATTTATGAATTCTCT
CACCCTGTGTAAGTAGCCTGGTGTTCGTTTGTCCAAGTGTACTTACCCTTGAGAACAAGTCTTGCAGTTGCCAGGTGTGTGCAGACGCCT
CTCCTGTGAGCGGCATCGCGGGCCCAGTCAGCTGCCCCGGCTCTCATCCTCGTCCTCACTGCCTTGGCTGAGCACTGTTGACGTGAACAG
CCACTGCAACAGGCAGCCCATCCCACTGTCCCCTCTGCCCTGGACTCCGCATGGCCTCCAAAAGCCAGCTTGCCCTCCGGGTGCTGCAGG
GGCTTTGCAGGTGGGGAAGGCTCTGGTGGGTGCCTTTGGTGGCTTCCGTGACATCAGCCGTGCTCTGATGCAGGCTTGCTCCCTCGTCAT
TCTCCCTCGTCATTCTCCCTCATCGTTCTGTGTGCATTTTTCTCTATGTCCTGACCTTTCTTCTTGCACCTAAAAGTGGTGTCTGGGTGC
AAATGTAAGCAGTGGTGGATCCAGAAATATGAGCTTTGTGTAATAAGCTTCTTAAAACAGTCCTTTCTTACACCTGCCCAGGGCCAGACC
CTCGGTCTTGGCCTTTTTCAGGAGCTAGGATATCTGCGCCTGGTGAAAATGAAACGAATTCCTGATTTAGGAATTCAGTGTTTCCTCCTC
ACTCCAGCTAAGCACTCACTTTTTTTTTTTTTTTTTTTTTTTTTTGATACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGC
GATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAATTGGGATTACAGGCATGCGCCA
CCATGCCCAGCTAATTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACT
GCCAGCTCCGCTTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCCAGGACTACAAGCACCCGCCACCACACCTGGCTAA
TTTTTTTGTATTTTTATTAGAGACAGTGTTTTACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCTACTCACCTCGGCCT
CCCAAAGTGCTGGGATTACGGGCAAGTTTTTATTAGAGATGGGGTTTCATCATGTTGGTCAGGCTGGTCTTCAACTCCTGACCTCAGGTG
ATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCTGAACTCTCAGTTCTAACGCAGGGATTCA
GGAATTGGGCTTTCAGACTCCTTCTGCAGTGTCACAGTCCAGACTTTTTTTAAATGAAGGACACCCCGCAGTGGCTCACAGTGGGTCCCA
GGGCTAGCAGGAGCGTGCTGGGGAGCCGGCTCTGTCTTTGTTCGCAGTGGGTCCCGGTGCTGGCAGGAGTGTGCTGGTGAGCCGGCTCTG
TCTTTGTAAATCCTTCAGGGGTCCTACGGCTGACTCCACCGGACAGCCCGTCCTGGGCCGTGTTAAGCACCTTTTGTAGAAATCGTATTT

>In-frame_DCAF6_ENST00000432587_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_5393nt
CTAAGAAGGAGAGTATGAGGCGAGCTCCGGCCCGGGTGCGGCCGGGCTTCAGGGGCCCAGGCGCCGCTGCTGCCACCGCCATCTAACGCT
GCGCCCTGGAGGCCCGGCGCGCGGATGGTGCCGGTGCGGCTCGGGTGTTGAAACGGGTGTCCCCTCCCCCTCCTCCCCTCCCCCACGCGG
TGGTCTCCCCTCCCACCCGGCTCAGGCAGAGCCATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTC
GGGCTGGAGGACCCGTCCCGGCTGCGGAGTCGATACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTG
AGGAACTGCCTGAATGTTCCATTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCT
CTGAGGCCCGAGTGCCTTCGCATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCT
GTGCGTGGCTGGCACTCTTCGCGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTG
GAGGAAGGCGGCCCGGTGTACAGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTAC
TACCATGGCTTCCGCCTGCTATGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGG
GAGCGCAGGCAGTTTCTCCGGATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTG
CTGCCTGTTGCTGTGAAGCTCTTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTT
CGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAA
GACTTCTCTGTGTTTTTCCAGAAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGAT
GAGCTGACCCTGGACAACCTGACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTG
CGCTTCCAGCTTACCATGCGGCTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAG
CTGCAGGCAGCGTGTCGGGCACGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTG
CACCTGCATCAGGAGATCCCCACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAG
TCCACACTGCAGACCCTCCCAGAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCC
AAGCTGGAGGCCACGCTGCAGGAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGAT
TTTGAGCCCGAACGTGTGGTAGCTGCTCCCCAAAGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACC
TTGAAGGACACTGCCCCGGTGCTGGAGGGCTTGAAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAG
CTGCAGGAGCAGAAGAAGTCACTCACCAAGGAGAAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAG
GAGATCAAGAAGGAACTTTCAAAGACTGGTGAAGAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAA
ATGATCGGGCAGATCGATGGCTTGATCTCGCAGCTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGG
GAGAACGTCATCAGTGTCGCTGAGCTCATCAACGCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCA
CTGGATGAAAACAAGGATGGCAAGGTCAACATCGACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACC
AGCCAGGTGGCTGAGATTGTAGCAACACTGGAAAAAGAGGAGAAGGTGGAGGAGAAGGAGAAGGCCAAAGAGAAGGCAGAGAAGGAGGTC
GCAGAGGTGAAGAGCTAGAACCACTGGCCTGGGCACCTGTCCTCCTGCTGTGCCGTCACCCTGGCAAGGGCCGTGAGGGCGATTGCTTTG
TGGTGATTCTCAGTGGCTCATCTAATATTTTGGCTGGAATAAATCAGAGACTTCCATAATCAAGTAAATTTTAATTTTCATCATTCCACG
GAGATTCAGTCTGTCTGGAATCCCGGAACCCCTCCACAGAATCGTGTCTGGATCCACACTGTGGTGTGGCTGCCACGGCCTCCTGGCTCC
AGAGGCAGCTGGGCTGGGCCAAGGCAGGAAGGCGCCCCCATGTGTGTGGCCTCAGTCTCAGCATCTGACTGTGCTGCCCTGTCCCCAGGG
AAGAGAATGAGGACCACGTGGACTCCGCCCACACAGAGCTGGCTGCTGTGCCCACCCTCAGGGGCGTCAGGAGACACAGCCTGGCCTCCT
CAGGGCTGAAGATGCCTCCATTCGCCTGTGGACCTTGATTTCTAGATTTCAGTGTCAATAGACCTGTCTTCCTGCACACTTTCAGTTGGA
TGTGGGTCATTGTGGAGACAGAGGTGTCTGCCATCTCTGTGGCCTCTGGAGAGTGACGTCTCCCTGCTGGGAGTGCTGGTTCTCACGTGC
GGTTTCCCTTGTGTATCGGAGCTCTTTCTCGGCTTTCTATTTCCCCCAGTTCTTTAAGCAGTCAATTGGCACAGAGTTTCCCACGGGGGC
TGCAGTGGATTCACTGTGTCAGGGATGAGCCTGGCTTGGGGGTTGGTGGGGCTCTGAAGCGCATTTGGGGTTCTTTGTAGCTTCTAATGT
GAGGTTTGAGTCCAGTGCGCCCACAGCAGCATGCCCTTCTCACCCCTTGCAGTGTTGCAGGCTCAGGCCCCTGGGCTCCTTCAGCAAGCA
GGCTAGTCAATGAGGCATGAGGATCCGGCACAGGGCATCCCCTGGGGCTTCAAGGGCAATACCCCCGTGCTTAGGGTTTGCCCTGTGCCC
TCTGGGTGGGGTGGCCTCCCCGCACTCGGCAGCATGGCCAGGCTGGCCAGGGCGTGGGCAGGTGGTGTCCTGTGGCACCTCCATCCTCCT
GCCCAGCCGGCTGTGTCACACTCATCTTTTTAAGGTCAGGTTGGTTCCTGGCAAAAATGTACCTCCAGGGGCCTCCAAGCATAGGATTTG
GAAGACAGGAACGGCACAGGCGTCCAGGAAAGCAGCTGCACTCAGACAATGCCTTCTCCATTACTTGAAGCTTCTTTCTGTTCAGCCATT
AAAGAAACTTGACAAAATAGGAACAGGAGATATTTCTCAATTGTAAACCTTTGTGCAGGGACAGTTGGCTTCCAGAGGCTTTCAGCTTTC
AGTTATTTGAGAAGTTTGTTTTAGATCCTTAACTAATATTTATGAATTCTCTCACCCTGTGTAAGTAGCCTGGTGTTCGTTTGTCCAAGT
GTACTTACCCTTGAGAACAAGTCTTGCAGTTGCCAGGTGTGTGCAGACGCCTCTCCTGTGAGCGGCATCGCGGGCCCAGTCAGCTGCCCC
GGCTCTCATCCTCGTCCTCACTGCCTTGGCTGAGCACTGTTGACGTGAACAGCCACTGCAACAGGCAGCCCATCCCACTGTCCCCTCTGC
CCTGGACTCCGCATGGCCTCCAAAAGCCAGCTTGCCCTCCGGGTGCTGCAGGGGCTTTGCAGGTGGGGAAGGCTCTGGTGGGTGCCTTTG
GTGGCTTCCGTGACATCAGCCGTGCTCTGATGCAGGCTTGCTCCCTCGTCATTCTCCCTCGTCATTCTCCCTCATCGTTCTGTGTGCATT
TTTCTCTATGTCCTGACCTTTCTTCTTGCACCTAAAAGTGGTGTCTGGGTGCAAATGTAAGCAGTGGTGGATCCAGAAATATGAGCTTTG
TGTAATAAGCTTCTTAAAACAGTCCTTTCTTACACCTGCCCAGGGCCAGACCCTCGGTCTTGGCCTTTTTCAGGAGCTAGGATATCTGCG
CCTGGTGAAAATGAAACGAATTCCTGATTTAGGAATTCAGTGTTTCCTCCTCACTCCAGCTAAGCACTCACTTTTTTTTTTTTTTTTTTT
TTTTTTTGATACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCAA
GCGATTCTTCTGCCTCAGCCTCCTGAGTAATTGGGATTACAGGCATGCGCCACCATGCCCAGCTAATTTTTTTTTTTTTTTTTGAGACAG
AGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACTGCCAGCTCCGCTTCCTGGGTTCACGCCATTCTCCTGCC
TCAGCCTCCCGAGTAGCCAGGACTACAAGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTATTAGAGACAGTGTTTTACCGTG
TTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCTACTCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCAAGTTTTTATTAGAG
ATGGGGTTTCATCATGTTGGTCAGGCTGGTCTTCAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACA
GGCATGAGCCACCGCGCCCGGCCTGAACTCTCAGTTCTAACGCAGGGATTCAGGAATTGGGCTTTCAGACTCCTTCTGCAGTGTCACAGT
CCAGACTTTTTTTAAATGAAGGACACCCCGCAGTGGCTCACAGTGGGTCCCAGGGCTAGCAGGAGCGTGCTGGGGAGCCGGCTCTGTCTT
TGTTCGCAGTGGGTCCCGGTGCTGGCAGGAGTGTGCTGGTGAGCCGGCTCTGTCTTTGTAAATCCTTCAGGGGTCCTACGGCTGACTCCA

>In-frame_DCAF6_ENST00000312263_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_5384nt
AGAGTATGAGGCGAGCTCCGGCCCGGGTGCGGCCGGGCTTCAGGGGCCCAGGCGCCGCTGCTGCCACCGCCATCTAACGCTGCGCCCTGG
AGGCCCGGCGCGCGGATGGTGCCGGTGCGGCTCGGGTGTTGAAACGGGTGTCCCCTCCCCCTCCTCCCCTCCCCCACGCGGTGGTCTCCC
CTCCCACCCGGCTCAGGCAGAGCCATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAG
GACCCGTCCCGGCTGCGGAGTCGATACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGC
CTGAATGTTCCATTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCC
GAGTGCCTTCGCATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGC
TGGCACTCTTCGCGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGC
GGCCCGGTGTACAGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGC
TTCCGCCTGCTATGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGG
CAGTTTCTCCGGATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTT
GCTGTGAAGCTCTTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAG
CTGGAGCTGGCCAAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCT
GTGTTTTTCCAGAAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACC
CTGGACAACCTGACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAG
CTTACCATGCGGCTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCA
GCGTGTCGGGCACGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCAT
CAGGAGATCCCCACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTG
CAGACCCTCCCAGAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAG
GCCACGCTGCAGGAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCC
GAACGTGTGGTAGCTGCTCCCCAAAGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGAC
ACTGCCCCGGTGCTGGAGGGCTTGAAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAG
CAGAAGAAGTCACTCACCAAGGAGAAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAG
AAGGAACTTTCAAAGACTGGTGAAGAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGG
CAGATCGATGGCTTGATCTCGCAGCTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTC
ATCAGTGTCGCTGAGCTCATCAACGCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAA
AACAAGGATGGCAAGGTCAACATCGACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTG
GCTGAGATTGTAGCAACACTGGAAAAAGAGGAGAAGGTGGAGGAGAAGGAGAAGGCCAAAGAGAAGGCAGAGAAGGAGGTCGCAGAGGTG
AAGAGCTAGAACCACTGGCCTGGGCACCTGTCCTCCTGCTGTGCCGTCACCCTGGCAAGGGCCGTGAGGGCGATTGCTTTGTGGTGATTC
TCAGTGGCTCATCTAATATTTTGGCTGGAATAAATCAGAGACTTCCATAATCAAGTAAATTTTAATTTTCATCATTCCACGGAGATTCAG
TCTGTCTGGAATCCCGGAACCCCTCCACAGAATCGTGTCTGGATCCACACTGTGGTGTGGCTGCCACGGCCTCCTGGCTCCAGAGGCAGC
TGGGCTGGGCCAAGGCAGGAAGGCGCCCCCATGTGTGTGGCCTCAGTCTCAGCATCTGACTGTGCTGCCCTGTCCCCAGGGAAGAGAATG
AGGACCACGTGGACTCCGCCCACACAGAGCTGGCTGCTGTGCCCACCCTCAGGGGCGTCAGGAGACACAGCCTGGCCTCCTCAGGGCTGA
AGATGCCTCCATTCGCCTGTGGACCTTGATTTCTAGATTTCAGTGTCAATAGACCTGTCTTCCTGCACACTTTCAGTTGGATGTGGGTCA
TTGTGGAGACAGAGGTGTCTGCCATCTCTGTGGCCTCTGGAGAGTGACGTCTCCCTGCTGGGAGTGCTGGTTCTCACGTGCGGTTTCCCT
TGTGTATCGGAGCTCTTTCTCGGCTTTCTATTTCCCCCAGTTCTTTAAGCAGTCAATTGGCACAGAGTTTCCCACGGGGGCTGCAGTGGA
TTCACTGTGTCAGGGATGAGCCTGGCTTGGGGGTTGGTGGGGCTCTGAAGCGCATTTGGGGTTCTTTGTAGCTTCTAATGTGAGGTTTGA
GTCCAGTGCGCCCACAGCAGCATGCCCTTCTCACCCCTTGCAGTGTTGCAGGCTCAGGCCCCTGGGCTCCTTCAGCAAGCAGGCTAGTCA
ATGAGGCATGAGGATCCGGCACAGGGCATCCCCTGGGGCTTCAAGGGCAATACCCCCGTGCTTAGGGTTTGCCCTGTGCCCTCTGGGTGG
GGTGGCCTCCCCGCACTCGGCAGCATGGCCAGGCTGGCCAGGGCGTGGGCAGGTGGTGTCCTGTGGCACCTCCATCCTCCTGCCCAGCCG
GCTGTGTCACACTCATCTTTTTAAGGTCAGGTTGGTTCCTGGCAAAAATGTACCTCCAGGGGCCTCCAAGCATAGGATTTGGAAGACAGG
AACGGCACAGGCGTCCAGGAAAGCAGCTGCACTCAGACAATGCCTTCTCCATTACTTGAAGCTTCTTTCTGTTCAGCCATTAAAGAAACT
TGACAAAATAGGAACAGGAGATATTTCTCAATTGTAAACCTTTGTGCAGGGACAGTTGGCTTCCAGAGGCTTTCAGCTTTCAGTTATTTG
AGAAGTTTGTTTTAGATCCTTAACTAATATTTATGAATTCTCTCACCCTGTGTAAGTAGCCTGGTGTTCGTTTGTCCAAGTGTACTTACC
CTTGAGAACAAGTCTTGCAGTTGCCAGGTGTGTGCAGACGCCTCTCCTGTGAGCGGCATCGCGGGCCCAGTCAGCTGCCCCGGCTCTCAT
CCTCGTCCTCACTGCCTTGGCTGAGCACTGTTGACGTGAACAGCCACTGCAACAGGCAGCCCATCCCACTGTCCCCTCTGCCCTGGACTC
CGCATGGCCTCCAAAAGCCAGCTTGCCCTCCGGGTGCTGCAGGGGCTTTGCAGGTGGGGAAGGCTCTGGTGGGTGCCTTTGGTGGCTTCC
GTGACATCAGCCGTGCTCTGATGCAGGCTTGCTCCCTCGTCATTCTCCCTCGTCATTCTCCCTCATCGTTCTGTGTGCATTTTTCTCTAT
GTCCTGACCTTTCTTCTTGCACCTAAAAGTGGTGTCTGGGTGCAAATGTAAGCAGTGGTGGATCCAGAAATATGAGCTTTGTGTAATAAG
CTTCTTAAAACAGTCCTTTCTTACACCTGCCCAGGGCCAGACCCTCGGTCTTGGCCTTTTTCAGGAGCTAGGATATCTGCGCCTGGTGAA
AATGAAACGAATTCCTGATTTAGGAATTCAGTGTTTCCTCCTCACTCCAGCTAAGCACTCACTTTTTTTTTTTTTTTTTTTTTTTTTTGA
TACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCAAGCGATTCTT
CTGCCTCAGCCTCCTGAGTAATTGGGATTACAGGCATGCGCCACCATGCCCAGCTAATTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCT
CTGTCTCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACTGCCAGCTCCGCTTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCC
CGAGTAGCCAGGACTACAAGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTATTAGAGACAGTGTTTTACCGTGTTAGCCAGG
ATGGTCTCGATCTCCTGACTTCGTGATCTACTCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCAAGTTTTTATTAGAGATGGGGTTT
CATCATGTTGGTCAGGCTGGTCTTCAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGC
CACCGCGCCCGGCCTGAACTCTCAGTTCTAACGCAGGGATTCAGGAATTGGGCTTTCAGACTCCTTCTGCAGTGTCACAGTCCAGACTTT
TTTTAAATGAAGGACACCCCGCAGTGGCTCACAGTGGGTCCCAGGGCTAGCAGGAGCGTGCTGGGGAGCCGGCTCTGTCTTTGTTCGCAG
TGGGTCCCGGTGCTGGCAGGAGTGTGCTGGTGAGCCGGCTCTGTCTTTGTAAATCCTTCAGGGGTCCTACGGCTGACTCCACCGGACAGC

>In-frame_DCAF6_ENST00000367840_chr1_167906246_+_LETM1_ENST00000302787_chr4_1850936_-_5274nt
GCCGGTGCGGCTCGGGTGTTGAAACGGGTGTCCCCTCCCCCTCCTCCCCTCCCCCACGCGGTGGTCTCCCCTCCCACCCGGCTCAGGCAG
AGCCATGTCTCGGGGTGGCTCCTACCCACACCTGTTGTGGGACGTGAGGAAAAGGTCCCTCGGGCTGGAGGACCCGTCCCGGCTGCGGAG
TCGATACCTGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCATTTGGCTG
CTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGCATAGTGTC
GAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCGCGCCCTGT
TCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTACAGCCCCCC
CGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTATGGATCGA
CACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGGATCTGCGC
TGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTCTTCCCCAA
CATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCCAAGTTCCT
CCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAGAAGATCCG
GGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTGACACGGCC
GCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGGCTGCGCTC
CATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCACGAGGCAT
GCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCCACATCGCT
GCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCAGAGATTGT
GGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAGGAGGAGGC
GGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCCGAACGTGTGGTAGCTGCTCC
CCAAAGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGACACTGCCCCGGTGCTGGAGGG
CTTGAAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAGCAGAAGAAGTCACTCACCAA
GGAGAAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAGAAGGAACTTTCAAAGACTGG
TGAAGAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGGCAGATCGATGGCTTGATCTC
GCAGCTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTCATCAGTGTCGCTGAGCTCAT
CAACGCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAAAACAAGGATGGCAAGGTCAA
CATCGACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTGGCTGAGATTGTAGCAACACT
GGAAAAAGAGGAGAAGGTGGAGGAGAAGGAGAAGGCCAAAGAGAAGGCAGAGAAGGAGGTCGCAGAGGTGAAGAGCTAGAACCACTGGCC
TGGGCACCTGTCCTCCTGCTGTGCCGTCACCCTGGCAAGGGCCGTGAGGGCGATTGCTTTGTGGTGATTCTCAGTGGCTCATCTAATATT
TTGGCTGGAATAAATCAGAGACTTCCATAATCAAGTAAATTTTAATTTTCATCATTCCACGGAGATTCAGTCTGTCTGGAATCCCGGAAC
CCCTCCACAGAATCGTGTCTGGATCCACACTGTGGTGTGGCTGCCACGGCCTCCTGGCTCCAGAGGCAGCTGGGCTGGGCCAAGGCAGGA
AGGCGCCCCCATGTGTGTGGCCTCAGTCTCAGCATCTGACTGTGCTGCCCTGTCCCCAGGGAAGAGAATGAGGACCACGTGGACTCCGCC
CACACAGAGCTGGCTGCTGTGCCCACCCTCAGGGGCGTCAGGAGACACAGCCTGGCCTCCTCAGGGCTGAAGATGCCTCCATTCGCCTGT
GGACCTTGATTTCTAGATTTCAGTGTCAATAGACCTGTCTTCCTGCACACTTTCAGTTGGATGTGGGTCATTGTGGAGACAGAGGTGTCT
GCCATCTCTGTGGCCTCTGGAGAGTGACGTCTCCCTGCTGGGAGTGCTGGTTCTCACGTGCGGTTTCCCTTGTGTATCGGAGCTCTTTCT
CGGCTTTCTATTTCCCCCAGTTCTTTAAGCAGTCAATTGGCACAGAGTTTCCCACGGGGGCTGCAGTGGATTCACTGTGTCAGGGATGAG
CCTGGCTTGGGGGTTGGTGGGGCTCTGAAGCGCATTTGGGGTTCTTTGTAGCTTCTAATGTGAGGTTTGAGTCCAGTGCGCCCACAGCAG
CATGCCCTTCTCACCCCTTGCAGTGTTGCAGGCTCAGGCCCCTGGGCTCCTTCAGCAAGCAGGCTAGTCAATGAGGCATGAGGATCCGGC
ACAGGGCATCCCCTGGGGCTTCAAGGGCAATACCCCCGTGCTTAGGGTTTGCCCTGTGCCCTCTGGGTGGGGTGGCCTCCCCGCACTCGG
CAGCATGGCCAGGCTGGCCAGGGCGTGGGCAGGTGGTGTCCTGTGGCACCTCCATCCTCCTGCCCAGCCGGCTGTGTCACACTCATCTTT
TTAAGGTCAGGTTGGTTCCTGGCAAAAATGTACCTCCAGGGGCCTCCAAGCATAGGATTTGGAAGACAGGAACGGCACAGGCGTCCAGGA
AAGCAGCTGCACTCAGACAATGCCTTCTCCATTACTTGAAGCTTCTTTCTGTTCAGCCATTAAAGAAACTTGACAAAATAGGAACAGGAG
ATATTTCTCAATTGTAAACCTTTGTGCAGGGACAGTTGGCTTCCAGAGGCTTTCAGCTTTCAGTTATTTGAGAAGTTTGTTTTAGATCCT
TAACTAATATTTATGAATTCTCTCACCCTGTGTAAGTAGCCTGGTGTTCGTTTGTCCAAGTGTACTTACCCTTGAGAACAAGTCTTGCAG
TTGCCAGGTGTGTGCAGACGCCTCTCCTGTGAGCGGCATCGCGGGCCCAGTCAGCTGCCCCGGCTCTCATCCTCGTCCTCACTGCCTTGG
CTGAGCACTGTTGACGTGAACAGCCACTGCAACAGGCAGCCCATCCCACTGTCCCCTCTGCCCTGGACTCCGCATGGCCTCCAAAAGCCA
GCTTGCCCTCCGGGTGCTGCAGGGGCTTTGCAGGTGGGGAAGGCTCTGGTGGGTGCCTTTGGTGGCTTCCGTGACATCAGCCGTGCTCTG
ATGCAGGCTTGCTCCCTCGTCATTCTCCCTCGTCATTCTCCCTCATCGTTCTGTGTGCATTTTTCTCTATGTCCTGACCTTTCTTCTTGC
ACCTAAAAGTGGTGTCTGGGTGCAAATGTAAGCAGTGGTGGATCCAGAAATATGAGCTTTGTGTAATAAGCTTCTTAAAACAGTCCTTTC
TTACACCTGCCCAGGGCCAGACCCTCGGTCTTGGCCTTTTTCAGGAGCTAGGATATCTGCGCCTGGTGAAAATGAAACGAATTCCTGATT
TAGGAATTCAGTGTTTCCTCCTCACTCCAGCTAAGCACTCACTTTTTTTTTTTTTTTTTTTTTTTTTTGATACAGAGTCTCGCTCTGTCA
CCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCTGAGTA
ATTGGGATTACAGGCATGCGCCACCATGCCCAGCTAATTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCTCCCAGGCTGGAGTG
CAATGGCGTGATCTCGGCTCACTGCCAGCTCCGCTTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCCAGGACTACAAG
CACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTATTAGAGACAGTGTTTTACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACT
TCGTGATCTACTCACCTCGGCCTCCCAAAGTGCTGGGATTACGGGCAAGTTTTTATTAGAGATGGGGTTTCATCATGTTGGTCAGGCTGG
TCTTCAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCTGAACT
CTCAGTTCTAACGCAGGGATTCAGGAATTGGGCTTTCAGACTCCTTCTGCAGTGTCACAGTCCAGACTTTTTTTAAATGAAGGACACCCC
GCAGTGGCTCACAGTGGGTCCCAGGGCTAGCAGGAGCGTGCTGGGGAGCCGGCTCTGTCTTTGTTCGCAGTGGGTCCCGGTGCTGGCAGG
AGTGTGCTGGTGAGCCGGCTCTGTCTTTGTAAATCCTTCAGGGGTCCTACGGCTGACTCCACCGGACAGCCCGTCCTGGGCCGTGTTAAG


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FusionGenePPI for DCAF6_LETM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCAF6DDB1, CUL4A, SP1, AR, DCAF6, NR3C1, DDA1, CBX2, CBX4, ACACA, KPNA1, USP9X, TRIM63, TRIM55, CUL4B, MOV10, NXF1, C1QTNF2, PIH1D1, MAGEA1, MAGEA4, NFKBIA, NR2E1, BMP15, COPS2, VPS28, DNAJB1, WDFY3, FAM46A, CALN1, YAF2, C10orf88, TRIM25, GTF2IRD1LETM1ICT1, TBK1, ILF3, C12orf57, SYNCRIP, LATS2, PSMA3, CYP1A1, NTRK1, NDUFA4, COQ9, PTPMT1, C15orf48, PPM1A, USP47, SNRNP27, PCDHGB4, HSD3B2, FGB, MRPS11, LYPD4, RNF19B, ATP6V0D1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCAF6_LETM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCAF6_LETM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCAF6C0033578Prostatic Neoplasms1CTD_human
TgeneLETM1C0026827Muscle hypotonia1CTD_human;HPO
TgeneLETM1C0036572Seizures1CTD_human;HPO
TgeneLETM1C0376634Craniofacial Abnormalities1CTD_human
TgeneLETM1C1956097Wolf-Hirschhorn Syndrome1CTD_human;ORPHANET
TgeneLETM1C2239176Liver carcinoma1CTD_human
TgeneLETM1C3714756Intellectual Disability1CTD_human