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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 937

FusionGeneSummary for ADPGK_ADPGK

check button Fusion gene summary
Fusion gene informationFusion gene name: ADPGK_ADPGK
Fusion gene ID: 937
HgeneTgene
Gene symbol

ADPGK

ADPGK

Gene ID

83440

83440

Gene nameADP dependent glucokinaseADP dependent glucokinase
Synonyms2610017G09Rik|ADP-GK2610017G09Rik|ADP-GK
Cytomap

15q24.1

15q24.1

Type of geneprotein-codingprotein-coding
DescriptionADP-dependent glucokinaseATP-dependent glucokinaserbBP-35ADP-dependent glucokinaseATP-dependent glucokinaserbBP-35
Modification date2018051920180519
UniProtAcc

Q9BRR6

Q9BRR6

Ensembl transtripts involved in fusion geneENST00000311669, ENST00000456471, 
ENST00000567733, 		ENST00000311669, 
ENST00000456471, ENST00000567733, 
Fusion gene scores* DoF score2 X 5 X 2=203 X 6 X 3=54
# samples 78
** MAII scorelog2(7/20*10)=1.8073549220576
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/54*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADPGK [Title/Abstract] AND ADPGK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADPGK

GO:0006006

glucose metabolic process

26555263

TgeneADPGK

GO:0006006

glucose metabolic process

26555263


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM728660ADPGKchr15

73044426

+ADPGKchr15

73044555

-
ChiTaRS3.1BQ669550ADPGKchr15

73045110

-ADPGKchr15

73067439

-
ChiTaRS3.1BQ669361ADPGKchr15

73045110

-ADPGKchr15

73067439

-
ChiTaRS3.1BQ668982ADPGKchr15

73045110

-ADPGKchr15

73067439

-
ChiTaRS3.1BU742597ADPGKchr15

73044555

+ADPGKchr15

73044426

-
ChiTaRS3.1BU676386ADPGKchr15

73043801

+ADPGKchr15

73043939

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000311669ENST00000311669ADPGKchr15

73044426

+ADPGKchr15

73044555

-
intron-3UTRENST00000311669ENST00000456471ADPGKchr15

73044426

+ADPGKchr15

73044555

-
intron-intronENST00000311669ENST00000567733ADPGKchr15

73044426

+ADPGKchr15

73044555

-
intron-3UTRENST00000456471ENST00000311669ADPGKchr15

73044426

+ADPGKchr15

73044555

-
intron-3UTRENST00000456471ENST00000456471ADPGKchr15

73044426

+ADPGKchr15

73044555

-
intron-intronENST00000456471ENST00000567733ADPGKchr15

73044426

+ADPGKchr15

73044555

-
intron-3UTRENST00000567733ENST00000311669ADPGKchr15

73044426

+ADPGKchr15

73044555

-
intron-3UTRENST00000567733ENST00000456471ADPGKchr15

73044426

+ADPGKchr15

73044555

-
intron-intronENST00000567733ENST00000567733ADPGKchr15

73044426

+ADPGKchr15

73044555

-
intron-3CDSENST00000311669ENST00000311669ADPGKchr15

73045110

-ADPGKchr15

73067439

-
intron-intronENST00000311669ENST00000456471ADPGKchr15

73045110

-ADPGKchr15

73067439

-
intron-5UTRENST00000311669ENST00000567733ADPGKchr15

73045110

-ADPGKchr15

73067439

-
intron-3CDSENST00000456471ENST00000311669ADPGKchr15

73045110

-ADPGKchr15

73067439

-
intron-intronENST00000456471ENST00000456471ADPGKchr15

73045110

-ADPGKchr15

73067439

-
intron-5UTRENST00000456471ENST00000567733ADPGKchr15

73045110

-ADPGKchr15

73067439

-
intron-3CDSENST00000567733ENST00000311669ADPGKchr15

73045110

-ADPGKchr15

73067439

-
intron-intronENST00000567733ENST00000456471ADPGKchr15

73045110

-ADPGKchr15

73067439

-
intron-5UTRENST00000567733ENST00000567733ADPGKchr15

73045110

-ADPGKchr15

73067439

-
intron-3UTRENST00000311669ENST00000311669ADPGKchr15

73044555

+ADPGKchr15

73044426

-
intron-intronENST00000311669ENST00000456471ADPGKchr15

73044555

+ADPGKchr15

73044426

-
intron-intronENST00000311669ENST00000567733ADPGKchr15

73044555

+ADPGKchr15

73044426

-
intron-3UTRENST00000456471ENST00000311669ADPGKchr15

73044555

+ADPGKchr15

73044426

-
intron-intronENST00000456471ENST00000456471ADPGKchr15

73044555

+ADPGKchr15

73044426

-
intron-intronENST00000456471ENST00000567733ADPGKchr15

73044555

+ADPGKchr15

73044426

-
intron-3UTRENST00000567733ENST00000311669ADPGKchr15

73044555

+ADPGKchr15

73044426

-
intron-intronENST00000567733ENST00000456471ADPGKchr15

73044555

+ADPGKchr15

73044426

-
intron-intronENST00000567733ENST00000567733ADPGKchr15

73044555

+ADPGKchr15

73044426

-
intron-3UTRENST00000311669ENST00000311669ADPGKchr15

73043801

+ADPGKchr15

73043939

-
intron-intronENST00000311669ENST00000456471ADPGKchr15

73043801

+ADPGKchr15

73043939

-
intron-intronENST00000311669ENST00000567733ADPGKchr15

73043801

+ADPGKchr15

73043939

-
intron-3UTRENST00000456471ENST00000311669ADPGKchr15

73043801

+ADPGKchr15

73043939

-
intron-intronENST00000456471ENST00000456471ADPGKchr15

73043801

+ADPGKchr15

73043939

-
intron-intronENST00000456471ENST00000567733ADPGKchr15

73043801

+ADPGKchr15

73043939

-
intron-3UTRENST00000567733ENST00000311669ADPGKchr15

73043801

+ADPGKchr15

73043939

-
intron-intronENST00000567733ENST00000456471ADPGKchr15

73043801

+ADPGKchr15

73043939

-
intron-intronENST00000567733ENST00000567733ADPGKchr15

73043801

+ADPGKchr15

73043939

-

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FusionProtFeatures for ADPGK_ADPGK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADPGK

Q9BRR6

ADPGK

Q9BRR6

Catalyzes the phosphorylation of D-glucose to D-glucose6-phosphate using ADP as the phosphate donor. GDP and CDP canreplace ADP, but with reduced efficiency (By similarity).{ECO:0000250}. Catalyzes the phosphorylation of D-glucose to D-glucose6-phosphate using ADP as the phosphate donor. GDP and CDP canreplace ADP, but with reduced efficiency (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADPGK_ADPGK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADPGK_ADPGK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADPGK_ADPGK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADPGK_ADPGK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource