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Fusion gene ID: 9358 |
FusionGeneSummary for DCAF16_GORAB |
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Fusion gene information | Fusion gene name: DCAF16_GORAB | Fusion gene ID: 9358 | Hgene | Tgene | Gene symbol | DCAF16 | GORAB | Gene ID | 54876 | 92344 |
Gene name | DDB1 and CUL4 associated factor 16 | golgin, RAB6 interacting | |
Synonyms | C4orf30 | GO|NTKLBP1|SCYL1BP1 | |
Cytomap | 4p15.31 | 1q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | DDB1- and CUL4-associated factor 16 | RAB6-interacting golginN-terminal kinase-like-binding protein 1NTKL-binding protein 1SCY1-like 1-binding protein 1SCYL1-BP1SCYL1-binding protein 1hNTKL-BP1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9NXF7 | Q5T7V8 | |
Ensembl transtripts involved in fusion gene | ENST00000382247, ENST00000536863, ENST00000507768, | ENST00000367763, ENST00000367762, ENST00000465717, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: DCAF16 [Title/Abstract] AND GORAB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW131866 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000382247 | ENST00000367763 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
intron-intron | ENST00000382247 | ENST00000367762 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
intron-intron | ENST00000382247 | ENST00000465717 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
intron-3UTR | ENST00000536863 | ENST00000367763 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
intron-intron | ENST00000536863 | ENST00000367762 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
intron-intron | ENST00000536863 | ENST00000465717 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
intron-3UTR | ENST00000507768 | ENST00000367763 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
intron-intron | ENST00000507768 | ENST00000367762 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
intron-intron | ENST00000507768 | ENST00000465717 | DCAF16 | chr4 | 17802442 | + | GORAB | chr1 | 170522255 | + |
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FusionProtFeatures for DCAF16_GORAB |
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Hgene | Tgene |
DCAF16 | GORAB |
May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DCAF16_GORAB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DCAF16_GORAB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DCAF16_GORAB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCAF16_GORAB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GORAB | C0029456 | Osteoporosis | 1 | CTD_human |
Tgene | GORAB | C0037268 | Skin Abnormalities | 1 | CTD_human |
Tgene | GORAB | C0432255 | Geroderma osteodysplastica | 1 | CTD_human;ORPHANET |