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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9357

FusionGeneSummary for DCAF16_CXCL14

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF16_CXCL14
Fusion gene ID: 9357
HgeneTgene
Gene symbol

DCAF16

CXCL14

Gene ID

54876

9547

Gene nameDDB1 and CUL4 associated factor 16C-X-C motif chemokine ligand 14
SynonymsC4orf30BMAC|BRAK|KEC|KS1|MIP-2g|MIP2G|NJAC|SCYB14
Cytomap

4p15.31

5q31.1

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 16C-X-C motif chemokine 14CXC chemokine in breast and kidneyMIP-2 gammabolekinebreast and kidneychemokine (C-X-C motif) ligand 14chemokine BRAKsmall inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK)small-inducible cytokine B14tumor-suppr
Modification date2018052320180519
UniProtAcc

Q9NXF7

O95715

Ensembl transtripts involved in fusion geneENST00000382247, ENST00000536863, 
ENST00000507768, 
ENST00000337225, 
ENST00000512158, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 1=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: DCAF16 [Title/Abstract] AND CXCL14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB217635DCAF16chr4

17803054

-CXCL14chr5

134914166

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000382247ENST00000337225DCAF16chr4

17803054

-CXCL14chr5

134914166

-
intron-3CDSENST00000382247ENST00000512158DCAF16chr4

17803054

-CXCL14chr5

134914166

-
intron-3CDSENST00000536863ENST00000337225DCAF16chr4

17803054

-CXCL14chr5

134914166

-
intron-3CDSENST00000536863ENST00000512158DCAF16chr4

17803054

-CXCL14chr5

134914166

-
intron-3CDSENST00000507768ENST00000337225DCAF16chr4

17803054

-CXCL14chr5

134914166

-
intron-3CDSENST00000507768ENST00000512158DCAF16chr4

17803054

-CXCL14chr5

134914166

-

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FusionProtFeatures for DCAF16_CXCL14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF16

Q9NXF7

CXCL14

O95715

May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}. Potent chemoattractant for neutrophils, and weaker fordendritic cells. Not chemotactic for T-cells, B-cells, monocytes,natural killer cells or granulocytes. Does not inhibitproliferation of myeloid progenitors in colony formation assays.{ECO:0000269|PubMed:10049774, ECO:0000269|PubMed:10946286}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCAF16_CXCL14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCAF16_CXCL14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCAF16_CXCL14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCAF16_CXCL14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCXCL14C0004096Asthma1CTD_human
TgeneCXCL14C0011616Contact Dermatitis1CTD_human
TgeneCXCL14C0014175Endometriosis1CTD_human
TgeneCXCL14C0024121Lung Neoplasms1CTD_human
TgeneCXCL14C0236969Substance-Related Disorders1CTD_human