![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 933 |
FusionGeneSummary for ADORA2B_SYN3 |
![]() |
Fusion gene information | Fusion gene name: ADORA2B_SYN3 | Fusion gene ID: 933 | Hgene | Tgene | Gene symbol | ADORA2B | SYN3 | Gene ID | 136 | 8224 |
Gene name | adenosine A2b receptor | synapsin III | |
Synonyms | ADORA2 | - | |
Cytomap | 17p12 | 22q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | adenosine receptor A2b | synapsin-3cN28H9.2 (synapsin III) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P29275 | O14994 | |
Ensembl transtripts involved in fusion gene | ENST00000304222, | ENST00000358763, ENST00000332840, ENST00000467095, | |
Fusion gene scores | * DoF score | 3 X 1 X 1=3 | 8 X 9 X 3=216 |
# samples | 2 | 9 | |
** MAII score | log2(2/3*10)=2.73696559416621 | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADORA2B [Title/Abstract] AND SYN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-FD-A3B6-01A | ADORA2B | chr17 | 15848897 | + | SYN3 | chr22 | 32992722 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000304222 | ENST00000358763 | ADORA2B | chr17 | 15848897 | + | SYN3 | chr22 | 32992722 | - |
Frame-shift | ENST00000304222 | ENST00000332840 | ADORA2B | chr17 | 15848897 | + | SYN3 | chr22 | 32992722 | - |
5CDS-intron | ENST00000304222 | ENST00000467095 | ADORA2B | chr17 | 15848897 | + | SYN3 | chr22 | 32992722 | - |
Top |
FusionProtFeatures for ADORA2B_SYN3 |
![]() |
Hgene | Tgene |
ADORA2B | SYN3 |
Receptor for adenosine. The activity of this receptor ismediated by G proteins which activate adenylyl cyclase. | May be involved in the regulation of neurotransmitterrelease and synaptogenesis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ADORA2B_SYN3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ADORA2B_SYN3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADORA2B | SLC9A3R2, EZR, TPD52L2, ZNF267 | SYN3 | SYN2, NOS1AP |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ADORA2B_SYN3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ADORA2B | P29275 | DB00277 | Theophylline | Adenosine receptor A2b | small molecule | approved |
Hgene | ADORA2B | P29275 | DB00640 | Adenosine | Adenosine receptor A2b | small molecule | approved|investigational |
Hgene | ADORA2B | P29275 | DB04932 | Defibrotide | Adenosine receptor A2b | biotech | approved|investigational |
Top |
RelatedDiseases for ADORA2B_SYN3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADORA2B | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | SYN3 | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | SYN3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | SYN3 | C0809983 | Schizophrenia and related disorders | 1 | PSYGENET |