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Fusion gene ID: 932 |
FusionGeneSummary for ADORA2B_PIGL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADORA2B_PIGL | Fusion gene ID: 932 | Hgene | Tgene | Gene symbol | ADORA2B | PIGL | Gene ID | 136 | 9487 |
| Gene name | adenosine A2b receptor | phosphatidylinositol glycan anchor biosynthesis class L | |
| Synonyms | ADORA2 | CHIME | |
| Cytomap | 17p12 | 17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenosine receptor A2b | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylaseN-acetylglucosaminylphosphatidylinositol deacetylasePIG-Lphosphatidylinositol glycan, class Lphosphatidylinositol-glycan biosynthesis class L protein | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P29275 | Q9Y2B2 | |
| Ensembl transtripts involved in fusion gene | ENST00000304222, | ENST00000581006, ENST00000498772, ENST00000225609, ENST00000395844, ENST00000463810, | |
| Fusion gene scores | * DoF score | 3 X 1 X 1=3 | 5 X 2 X 5=50 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/3*10)=2.73696559416621 | log2(5/50*10)=0 | |
| Context | PubMed: ADORA2B [Title/Abstract] AND PIGL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-ZF-AA51-01A | ADORA2B | chr17 | 15848897 | + | PIGL | chr17 | 16203202 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000304222 | ENST00000581006 | ADORA2B | chr17 | 15848897 | + | PIGL | chr17 | 16203202 | + |
| In-frame | ENST00000304222 | ENST00000498772 | ADORA2B | chr17 | 15848897 | + | PIGL | chr17 | 16203202 | + |
| In-frame | ENST00000304222 | ENST00000225609 | ADORA2B | chr17 | 15848897 | + | PIGL | chr17 | 16203202 | + |
| In-frame | ENST00000304222 | ENST00000395844 | ADORA2B | chr17 | 15848897 | + | PIGL | chr17 | 16203202 | + |
| 5CDS-intron | ENST00000304222 | ENST00000463810 | ADORA2B | chr17 | 15848897 | + | PIGL | chr17 | 16203202 | + |
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FusionProtFeatures for ADORA2B_PIGL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADORA2B | PIGL |
| Receptor for adenosine. The activity of this receptor ismediated by G proteins which activate adenylyl cyclase. | Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 1_8 | 111 | 333 | Topological domain | Extracellular |
| Hgene | ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 34_43 | 111 | 333 | Topological domain | Cytoplasmic |
| Hgene | ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 68_78 | 111 | 333 | Topological domain | Extracellular |
| Hgene | ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 44_67 | 111 | 333 | Transmembrane | Helical%3B Name%3D2 |
| Hgene | ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 79_101 | 111 | 333 | Transmembrane | Helical%3B Name%3D3 |
| Hgene | ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 9_33 | 111 | 333 | Transmembrane | Helical%3B Name%3D1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 173_182 | 111 | 333 | Region | Agonist binding |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 247_254 | 111 | 333 | Region | Agonist binding |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 266_276 | 111 | 333 | Region | Agonist binding |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 102_121 | 111 | 333 | Topological domain | Cytoplasmic |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 145_178 | 111 | 333 | Topological domain | Extracellular |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 204_235 | 111 | 333 | Topological domain | Cytoplasmic |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 260_267 | 111 | 333 | Topological domain | Extracellular |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 292_332 | 111 | 333 | Topological domain | Cytoplasmic |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 122_144 | 111 | 333 | Transmembrane | Helical%3B Name%3D4 |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 179_203 | 111 | 333 | Transmembrane | Helical%3B Name%3D5 |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 236_259 | 111 | 333 | Transmembrane | Helical%3B Name%3D6 |
| Hgene | >ADORA2B | chr17:15848897 | chr17:16203202 | ENST00000304222 | + | 1 | 2 | 268_291 | 111 | 333 | Transmembrane | Helical%3B Name%3D7 |
| Tgene | PIGL | chr17:15848897 | chr17:16203202 | ENST00000225609 | + | 1 | 7 | 23_252 | 111 | 253 | Topological domain | Cytoplasmic |
| Tgene | PIGL | chr17:15848897 | chr17:16203202 | ENST00000225609 | + | 1 | 7 | 2_22 | 111 | 253 | Transmembrane | Helical |
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FusionGeneSequence for ADORA2B_PIGL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000581006_chr17_16203202_+_151aa MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQ >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000498772_chr17_16203202_+_195aa MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQ SSIFSLLAVAVDRYLAICVPLRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGKACS >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000225609_chr17_16203202_+_253aa MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQ SSIFSLLAVAVDRYLAICVPLRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVL >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000395844_chr17_16203202_+_245aa MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQ SSIFSLLAVAVDRYLAICVPLRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRVLCAHASVCECAAQV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000581006_chr17_16203202_+_453nt ATGCTGCTGGAGACACAGGACGCGCTGTACGTGGCGCTGGAGCTGGTCATCGCCGCGCTTTCGGTGGCGGGCAACGTGCTGGTGTGCGCC GCGGTGGGCACGGCGAACACTCTGCAGACGCCCACCAACTACTTCCTGGTGTCCCTGGCTGCGGCCGACGTGGCCGTGGGGCTCTTCGCC ATCCCCTTTGCCATCACCATCAGCCTGGGCTTCTGCACTGACTTCTACGGCTGCCTCTTCCTCGCCTGCTTCGTGCTGGTGCTCACGCAG AGCTCCATCTTCAGCCTTCTGGCCGTGGCAGTCGACAGATACCTGGCCATCTGTGTCCCGCTCAGGGATTTCCCAGATGACCCAGGCATG CAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGAAAGACAGAGCAAATTCCAGATTG >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000498772_chr17_16203202_+_585nt ATGCTGCTGGAGACACAGGACGCGCTGTACGTGGCGCTGGAGCTGGTCATCGCCGCGCTTTCGGTGGCGGGCAACGTGCTGGTGTGCGCC GCGGTGGGCACGGCGAACACTCTGCAGACGCCCACCAACTACTTCCTGGTGTCCCTGGCTGCGGCCGACGTGGCCGTGGGGCTCTTCGCC ATCCCCTTTGCCATCACCATCAGCCTGGGCTTCTGCACTGACTTCTACGGCTGCCTCTTCCTCGCCTGCTTCGTGCTGGTGCTCACGCAG AGCTCCATCTTCAGCCTTCTGGCCGTGGCAGTCGACAGATACCTGGCCATCTGTGTCCCGCTCAGGGATTTCCCAGATGACCCAGGCATG CAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTCGATGCAGGGGGA GTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGTAAGGCTTGTTCC >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000225609_chr17_16203202_+_759nt ATGCTGCTGGAGACACAGGACGCGCTGTACGTGGCGCTGGAGCTGGTCATCGCCGCGCTTTCGGTGGCGGGCAACGTGCTGGTGTGCGCC GCGGTGGGCACGGCGAACACTCTGCAGACGCCCACCAACTACTTCCTGGTGTCCCTGGCTGCGGCCGACGTGGCCGTGGGGCTCTTCGCC ATCCCCTTTGCCATCACCATCAGCCTGGGCTTCTGCACTGACTTCTACGGCTGCCTCTTCCTCGCCTGCTTCGTGCTGGTGCTCACGCAG AGCTCCATCTTCAGCCTTCTGGCCGTGGCAGTCGACAGATACCTGGCCATCTGTGTCCCGCTCAGGGATTTCCCAGATGACCCAGGCATG CAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTCGATGCAGGGGGA GTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGGTGCTCTGTGCTC ACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGATGTCCTCTTCGTG CTCAACAGCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTC >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000395844_chr17_16203202_+_735nt ATGCTGCTGGAGACACAGGACGCGCTGTACGTGGCGCTGGAGCTGGTCATCGCCGCGCTTTCGGTGGCGGGCAACGTGCTGGTGTGCGCC GCGGTGGGCACGGCGAACACTCTGCAGACGCCCACCAACTACTTCCTGGTGTCCCTGGCTGCGGCCGACGTGGCCGTGGGGCTCTTCGCC ATCCCCTTTGCCATCACCATCAGCCTGGGCTTCTGCACTGACTTCTACGGCTGCCTCTTCCTCGCCTGCTTCGTGCTGGTGCTCACGCAG AGCTCCATCTTCAGCCTTCTGGCCGTGGCAGTCGACAGATACCTGGCCATCTGTGTCCCGCTCAGGGATTTCCCAGATGACCCAGGCATG CAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTCGATGCAGGGGGA GTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGTGCTCTGTGCTCACGCTTCAGTCTGTGAATGTGCTGCGCAAGTA CATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAGAA AGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTCTCCCGGTACATGAGAATCAACTCACTGAGCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000581006_chr17_16203202_+_868nt GGGCAATTTGTTAGTTATCCGCCGCCACCAAGACGCGGCACGGCGCCTGGACCGGAGGGGCCCCGCGCGGGCGCGAACTTTGGGCTCGGG CGAGTGGGTGGTGCTCCGCCCAGCCCGAGACGGGCGGGCGCGCGGGCCAATGGGTGCCGCCTCTTGGCCGCGGGGGGCCCCGACCCGTGG GTCCCGGCCACCAGCGCCCCAGCCCCGAGGCTCAGAAGCGGCAGGCGGAGGCGCGGTCCGGGCGCTATGGCCATGCCCGGCGGGTCTCAC GCGGCTGCCCCTCGCCCGGCGCGCCTTCGGTAGGGGGCGCCCGGGGCCCAGCTGGCCCGGCCATGCTGCTGGAGACACAGGACGCGCTGT ACGTGGCGCTGGAGCTGGTCATCGCCGCGCTTTCGGTGGCGGGCAACGTGCTGGTGTGCGCCGCGGTGGGCACGGCGAACACTCTGCAGA CGCCCACCAACTACTTCCTGGTGTCCCTGGCTGCGGCCGACGTGGCCGTGGGGCTCTTCGCCATCCCCTTTGCCATCACCATCAGCCTGG GCTTCTGCACTGACTTCTACGGCTGCCTCTTCCTCGCCTGCTTCGTGCTGGTGCTCACGCAGAGCTCCATCTTCAGCCTTCTGGCCGTGG CAGTCGACAGATACCTGGCCATCTGTGTCCCGCTCAGGGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAG TCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGAAAGACAGAGCAAATTCCAGATTGTGAGCAGCCACCTGCATCCTCTATGCCT >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000498772_chr17_16203202_+_1261nt GGGCAATTTGTTAGTTATCCGCCGCCACCAAGACGCGGCACGGCGCCTGGACCGGAGGGGCCCCGCGCGGGCGCGAACTTTGGGCTCGGG CGAGTGGGTGGTGCTCCGCCCAGCCCGAGACGGGCGGGCGCGCGGGCCAATGGGTGCCGCCTCTTGGCCGCGGGGGGCCCCGACCCGTGG GTCCCGGCCACCAGCGCCCCAGCCCCGAGGCTCAGAAGCGGCAGGCGGAGGCGCGGTCCGGGCGCTATGGCCATGCCCGGCGGGTCTCAC GCGGCTGCCCCTCGCCCGGCGCGCCTTCGGTAGGGGGCGCCCGGGGCCCAGCTGGCCCGGCCATGCTGCTGGAGACACAGGACGCGCTGT ACGTGGCGCTGGAGCTGGTCATCGCCGCGCTTTCGGTGGCGGGCAACGTGCTGGTGTGCGCCGCGGTGGGCACGGCGAACACTCTGCAGA CGCCCACCAACTACTTCCTGGTGTCCCTGGCTGCGGCCGACGTGGCCGTGGGGCTCTTCGCCATCCCCTTTGCCATCACCATCAGCCTGG GCTTCTGCACTGACTTCTACGGCTGCCTCTTCCTCGCCTGCTTCGTGCTGGTGCTCACGCAGAGCTCCATCTTCAGCCTTCTGGCCGTGG CAGTCGACAGATACCTGGCCATCTGTGTCCCGCTCAGGGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAG TCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTC TGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGTAAGGCTTGTTCCTTTTGCAAAGGGCCACAAGATACTGTCC CTCTGAGAAACTTATGAGGGGGAAATTTGCAAATCCACAGAGAGCTGCCCTCAGCCGAGCAGAGGCAGTGGTTGGGGAGGCCGCCACACT CTTCCTGACTCACCTCAAGGTACCTGGCAGGTTGTATCTACCAGCAAGTGCCTGCCTGCAGGGCCACCTCTGGATGAGTGGGGAGGCCAG GTTTGCCCCTCAACCTGTCTAGCTTTTTCACAGGGTGGATGTTTTACACCTCTGGTATTCTTCCAGTCTGAACTCAATCCCATCCCCCAA CCAATTAGGCAGGTTGTAAATGACTGCTGGGTGCTTGATGAACCAATCTGCCTGAGTTAGGAACTCTTCCTAACCCACATAAAGTATTTG >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000225609_chr17_16203202_+_1452nt GGGCAATTTGTTAGTTATCCGCCGCCACCAAGACGCGGCACGGCGCCTGGACCGGAGGGGCCCCGCGCGGGCGCGAACTTTGGGCTCGGG CGAGTGGGTGGTGCTCCGCCCAGCCCGAGACGGGCGGGCGCGCGGGCCAATGGGTGCCGCCTCTTGGCCGCGGGGGGCCCCGACCCGTGG GTCCCGGCCACCAGCGCCCCAGCCCCGAGGCTCAGAAGCGGCAGGCGGAGGCGCGGTCCGGGCGCTATGGCCATGCCCGGCGGGTCTCAC GCGGCTGCCCCTCGCCCGGCGCGCCTTCGGTAGGGGGCGCCCGGGGCCCAGCTGGCCCGGCCATGCTGCTGGAGACACAGGACGCGCTGT ACGTGGCGCTGGAGCTGGTCATCGCCGCGCTTTCGGTGGCGGGCAACGTGCTGGTGTGCGCCGCGGTGGGCACGGCGAACACTCTGCAGA CGCCCACCAACTACTTCCTGGTGTCCCTGGCTGCGGCCGACGTGGCCGTGGGGCTCTTCGCCATCCCCTTTGCCATCACCATCAGCCTGG GCTTCTGCACTGACTTCTACGGCTGCCTCTTCCTCGCCTGCTTCGTGCTGGTGCTCACGCAGAGCTCCATCTTCAGCCTTCTGGCCGTGG CAGTCGACAGATACCTGGCCATCTGTGTCCCGCTCAGGGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAG TCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTC TGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGGTGCTCTGTGCTCACGCTTCAGTCTGTGAATGTGCTGCGCA AGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCA AGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTCTCCCGGTACATGAGAATCAACTCACTGA GCTTCCTCTGAAGCCTTGAAGGGTTTTCAGATCCAAGGAACAAAGGGGAAAATAGACAAAGGAGTGCAGAGGACCTGGCCTGGCACTGGC TTATTTACCTGAGCTCAAGGAGATCCCCGCTGGAGCAGCCTCTGCAAAAGGGAGCCCATGTAGGCCAGGGGCTGTCCAAACTCCAGCTTC TTCCCCTGGGAAAAAACCCAAAGAACCAAAAACAAACCACCCCAAGGATAATAATAGCTACACTGCTAGCTTCTCAAGTTCTTGTGAAAA ACAATTTACATAATGACACAGTAGATGTGGAACACCTAGCCCAGTGCCTGGGCAGGTCCCTATTATCATAAATGAACATAAAAGTGCTCT >In-frame_ADORA2B_ENST00000304222_chr17_15848897_+_PIGL_ENST00000395844_chr17_16203202_+_1572nt GGGCAATTTGTTAGTTATCCGCCGCCACCAAGACGCGGCACGGCGCCTGGACCGGAGGGGCCCCGCGCGGGCGCGAACTTTGGGCTCGGG CGAGTGGGTGGTGCTCCGCCCAGCCCGAGACGGGCGGGCGCGCGGGCCAATGGGTGCCGCCTCTTGGCCGCGGGGGGCCCCGACCCGTGG GTCCCGGCCACCAGCGCCCCAGCCCCGAGGCTCAGAAGCGGCAGGCGGAGGCGCGGTCCGGGCGCTATGGCCATGCCCGGCGGGTCTCAC GCGGCTGCCCCTCGCCCGGCGCGCCTTCGGTAGGGGGCGCCCGGGGCCCAGCTGGCCCGGCCATGCTGCTGGAGACACAGGACGCGCTGT ACGTGGCGCTGGAGCTGGTCATCGCCGCGCTTTCGGTGGCGGGCAACGTGCTGGTGTGCGCCGCGGTGGGCACGGCGAACACTCTGCAGA CGCCCACCAACTACTTCCTGGTGTCCCTGGCTGCGGCCGACGTGGCCGTGGGGCTCTTCGCCATCCCCTTTGCCATCACCATCAGCCTGG GCTTCTGCACTGACTTCTACGGCTGCCTCTTCCTCGCCTGCTTCGTGCTGGTGCTCACGCAGAGCTCCATCTTCAGCCTTCTGGCCGTGG CAGTCGACAGATACCTGGCCATCTGTGTCCCGCTCAGGGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAG TCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCTGGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTC TGTATGCAGCTGTGAGGGTGCTCTGTGCTCACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCT CTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTC CTCTGGTTCCGCCGCCTCTACATTATCTTCTCCCGGTACATGAGAATCAACTCACTGAGCTTCCTCTGAAGCCTTGAAGGGTTTTCAGAT CCAAGGAACAAAGGGGAAAATAGACAAAGGAGTGCAGAGGACCTGGCCTGGCACTGGCTTATTTACCTGAGCTCAAGGAGATCCCCGCTG GAGCAGCCTCTGCAAAAGGGAGCCCATGTAGGCCAGGGGCTGTCCAAACTCCAGCTTCTTCCCCTGGGAAAAAACCCAAAGAACCAAAAA CAAACCACCCCAAGGATAATAATAGCTACACTGCTAGCTTCTCAAGTTCTTGTGAAAAACAATTTACATAATGACACAGTAGATGTGGAA CACCTAGCCCAGTGCCTGGGCAGGTCCCTATTATCATAAATGAACATAAAAGTGCTCTAAAAACACTCCACAGATGTGACTTTTACATTG TTTCCAAAGCAGGTTCACCAAAAACACATACACAAAATGCAACAGTGTGTGTTGAATTGGTTCAATCATAATTCCTTTGATTTTTCTTGT |
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FusionGenePPI for ADORA2B_PIGL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADORA2B | SLC9A3R2, EZR, TPD52L2, ZNF267 | PIGL | MEIS2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADORA2B_PIGL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ADORA2B | P29275 | DB00277 | Theophylline | Adenosine receptor A2b | small molecule | approved |
| Hgene | ADORA2B | P29275 | DB00640 | Adenosine | Adenosine receptor A2b | small molecule | approved|investigational |
| Hgene | ADORA2B | P29275 | DB04932 | Defibrotide | Adenosine receptor A2b | biotech | approved|investigational |
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RelatedDiseases for ADORA2B_PIGL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADORA2B | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | PIGL | C1848392 | Zunich neuroectodermal syndrome | 1 | ORPHANET;UNIPROT |
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