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Fusion gene ID: 93 |
FusionGeneSummary for ABCA1_EIF4E |
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Fusion gene information | Fusion gene name: ABCA1_EIF4E | Fusion gene ID: 93 | Hgene | Tgene | Gene symbol | ABCA1 | EIF4E | Gene ID | 19 | 1977 |
Gene name | ATP binding cassette subfamily A member 1 | eukaryotic translation initiation factor 4E | |
Synonyms | ABC-1|ABC1|CERP|HDLDT1|TGD | AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F|eIF-4E | |
Cytomap | 9q31.1 | 4q23 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP-binding cassette sub-family A member 1ATP-binding cassette transporter A1ATP-binding cassette, sub-family A (ABC1), member 1cholesterol efflux regulatory proteinmembrane-bound | eukaryotic translation initiation factor 4EeIF-4F 25 kDa subuniteukaryotic translation initiation factor 4E-like 1mRNA cap-binding protein | |
Modification date | 20180527 | 20180522 | |
UniProtAcc | O95477 | P06730 | |
Ensembl transtripts involved in fusion gene | ENST00000374736, ENST00000494467, ENST00000423487, ENST00000374733, | ENST00000450253, ENST00000280892, ENST00000504432, ENST00000505992, ENST00000504472, | |
Fusion gene scores | * DoF score | 11 X 7 X 7=539 | 3 X 3 X 2=18 |
# samples | 10 | 3 | |
** MAII score | log2(10/539*10)=-2.43028527297778 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ABCA1 [Title/Abstract] AND EIF4E [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ABCA1 | GO:0007040 | lysosome organization | 15163665 |
Hgene | ABCA1 | GO:0008203 | cholesterol metabolic process | 14747463 |
Hgene | ABCA1 | GO:0016197 | endosomal transport | 14747463 |
Hgene | ABCA1 | GO:0033344 | cholesterol efflux | 10431236|11162594|23931754 |
Hgene | ABCA1 | GO:0033700 | phospholipid efflux | 10431236|11162594 |
Hgene | ABCA1 | GO:0042632 | cholesterol homeostasis | 10431236 |
Hgene | ABCA1 | GO:0045332 | phospholipid translocation | 24097981 |
Tgene | EIF4E | GO:0006417 | regulation of translation | 22578813 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF879888 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000374736 | ENST00000450253 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000374736 | ENST00000280892 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000374736 | ENST00000504432 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000374736 | ENST00000505992 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000374736 | ENST00000504472 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000494467 | ENST00000450253 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000494467 | ENST00000280892 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000494467 | ENST00000504432 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000494467 | ENST00000505992 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000494467 | ENST00000504472 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000423487 | ENST00000450253 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000423487 | ENST00000280892 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000423487 | ENST00000504432 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000423487 | ENST00000505992 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000423487 | ENST00000504472 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000374733 | ENST00000450253 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000374733 | ENST00000280892 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000374733 | ENST00000504432 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000374733 | ENST00000505992 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
intron-intron | ENST00000374733 | ENST00000504472 | ABCA1 | chr9 | 107587996 | - | EIF4E | chr4 | 99810001 | - |
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FusionProtFeatures for ABCA1_EIF4E |
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Hgene | Tgene |
ABCA1 | EIF4E |
Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation of proteinsynthesis and facilitates ribosome binding by inducing theunwinding of the mRNAs secondary structures. Component of theCYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediatestranslational repression. In the CYFIP1-EIF4E-FMR1 complex thissubunit mediates the binding to the mRNA cap.{ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ABCA1_EIF4E |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ABCA1_EIF4E |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ABCA1_EIF4E |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ABCA1 | O95477 | DB01016 | Glyburide | ATP-binding cassette sub-family A member 1 | small molecule | approved |
Hgene | ABCA1 | O95477 | DB01599 | Probucol | ATP-binding cassette sub-family A member 1 | small molecule | approved|investigational |
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RelatedDiseases for ABCA1_EIF4E |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ABCA1 | C0039292 | Tangier Disease | 19 | CTD_human;ORPHANET;UNIPROT |
Hgene | ABCA1 | C1704429 | Hypoalphalipoproteinemia, Familial | 4 | ORPHANET;UNIPROT |
Hgene | ABCA1 | C2931838 | Familial HDL deficiency | 2 | CTD_human |
Hgene | ABCA1 | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | ABCA1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | ABCA1 | C0020443 | Hypercholesterolemia | 1 | CTD_human |
Hgene | ABCA1 | C0020445 | Hypercholesterolemia, Familial | 1 | CTD_human |
Hgene | ABCA1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | ABCA1 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Hgene | ABCA1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | EIF4E | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | CTD_human |