|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 9298 |
FusionGeneSummary for DAPP1_COL4A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DAPP1_COL4A3 | Fusion gene ID: 9298 | Hgene | Tgene | Gene symbol | DAPP1 | COL4A3 | Gene ID | 27071 | 1285 |
| Gene name | dual adaptor of phosphotyrosine and 3-phosphoinositides 1 | collagen type IV alpha 3 chain | |
| Synonyms | BAM32 | - | |
| Cytomap | 4q23 | 2q36.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositideB-cell adapter molecule of 32 kDab lymphocyte adapter protein Bam32hDAPP1 | collagen alpha-3(IV) chaincollagen IV, alpha-3 polypeptidecollagen, type IV, alpha 3 (Goodpasture antigen)tumstatin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UN19 | Q01955 | |
| Ensembl transtripts involved in fusion gene | ENST00000296414, ENST00000512369, | ENST00000396578, ENST00000468753, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DAPP1 [Title/Abstract] AND COL4A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | COL4A3 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 10766752 |
| Tgene | COL4A3 | GO:0008283 | cell proliferation | 10766752 |
| Tgene | COL4A3 | GO:0016525 | negative regulation of angiogenesis | 10766752|12682293 |
| Tgene | COL4A3 | GO:0072577 | endothelial cell apoptotic process | 10766752 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-T2-A6X0-01A | DAPP1 | chr4 | 100784229 | + | COL4A3 | chr2 | 228176502 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000296414 | ENST00000396578 | DAPP1 | chr4 | 100784229 | + | COL4A3 | chr2 | 228176502 | + |
| 5CDS-intron | ENST00000296414 | ENST00000468753 | DAPP1 | chr4 | 100784229 | + | COL4A3 | chr2 | 228176502 | + |
| In-frame | ENST00000512369 | ENST00000396578 | DAPP1 | chr4 | 100784229 | + | COL4A3 | chr2 | 228176502 | + |
| 5CDS-intron | ENST00000512369 | ENST00000468753 | DAPP1 | chr4 | 100784229 | + | COL4A3 | chr2 | 228176502 | + |
Top |
FusionProtFeatures for DAPP1_COL4A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DAPP1 | COL4A3 |
| May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.{ECO:0000269|PubMed:10770799}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DAPP1 | chr4:100784229 | chr2:228176502 | ENST00000512369 | + | 6 | 9 | 35_129 | 200 | 281 | Domain | SH2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DAPP1 | chr4:100784229 | chr2:228176502 | ENST00000512369 | + | 6 | 9 | 164_259 | 200 | 281 | Domain | PH |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 1445_1669 | 1642 | 1671 | Domain | Collagen IV NC1 |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 1154_1156 | 1642 | 1671 | Motif | Cell attachment site |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 1306_1308 | 1642 | 1671 | Motif | Cell attachment site |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 1345_1347 | 1642 | 1671 | Motif | Cell attachment site |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 1432_1434 | 1642 | 1671 | Motif | Cell attachment site |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 791_793 | 1642 | 1671 | Motif | Cell attachment site |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 996_998 | 1642 | 1671 | Motif | Cell attachment site |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 1427_1444 | 1642 | 1671 | Region | Note=Epitope recognized by Goodpasture antibodies |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 1479_1557 | 1642 | 1671 | Region | Note=Required for the anti-angiogenic activity of tumstatin |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 1610_1628 | 1642 | 1671 | Region | Note=Required for the anti-tumor cell activity of tumstatin |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 29_42 | 1642 | 1671 | Region | Note=7S domain |
| Tgene | COL4A3 | chr4:100784229 | chr2:228176502 | ENST00000396578 | + | 50 | 52 | 43_1438 | 1642 | 1671 | Region | Note=Triple-helical region |
Top |
FusionGeneSequence for DAPP1_COL4A3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DAPP1_ENST00000296414_chr4_100784229_+_COL4A3_ENST00000396578_chr2_228176502_+_228aa MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGY SFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKT >In-frame_DAPP1_ENST00000512369_chr4_100784229_+_COL4A3_ENST00000396578_chr2_228176502_+_228aa MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGY SFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DAPP1_ENST00000296414_chr4_100784229_+_COL4A3_ENST00000396578_chr2_228176502_+_685nt ATGGGCAGAGCAGAACTTCTAGAAGGGAAGATGAGCACCCAGGATCCCTCAGATCTGTGGAGCAGATCCGATGGAGAGGCTGAGCTGCTC CAGGACTTGGGGTGGTATCACGGCAACCTCACACGCCATGCTGCTGAAGCTCTTCTCCTCTCAAATGGATGTGACGGCAGCTACCTTCTG AGGGACAGCAATGAGACCACCGGGCTGTACTCTCTCTCTGTGAGGGCCAAAGATTCTGTTAAACACTTTCATGTTGAATATACTGGATAT TCATTTAAATTTGGCTTTAATGAATTCTCATCTTTGAAGGATTTTGTCAAGCATTTTGCAAATCAGCCTTTGATTGGAAGCGAGACAGGC ACTCTGATGGTTCTAAAACATCCCTACCCAAGAAAAGTGGAAGAACCCTCCATTTATGAATCTGTCCGGGTTCACACAGCAATGCAGACA GGAAGAACAGAAGATGACCTTGTGCCCACAGCACCTTCTCTGGGCACCAAAGAAGGTTACCTCACCAAACAGGGAGGCCTGGTCAAGACC TGGAAAACAAGATGGTTTACTCTGCACAGGAATGAACTGAAATACTTCAAAGACCAGATGAAAGCCTATTCCATCAACTGTGAAAGCTGG >In-frame_DAPP1_ENST00000512369_chr4_100784229_+_COL4A3_ENST00000396578_chr2_228176502_+_685nt ATGGGCAGAGCAGAACTTCTAGAAGGGAAGATGAGCACCCAGGATCCCTCAGATCTGTGGAGCAGATCCGATGGAGAGGCTGAGCTGCTC CAGGACTTGGGGTGGTATCACGGCAACCTCACACGCCATGCTGCTGAAGCTCTTCTCCTCTCAAATGGATGTGACGGCAGCTACCTTCTG AGGGACAGCAATGAGACCACCGGGCTGTACTCTCTCTCTGTGAGGGCCAAAGATTCTGTTAAACACTTTCATGTTGAATATACTGGATAT TCATTTAAATTTGGCTTTAATGAATTCTCATCTTTGAAGGATTTTGTCAAGCATTTTGCAAATCAGCCTTTGATTGGAAGCGAGACAGGC ACTCTGATGGTTCTAAAACATCCCTACCCAAGAAAAGTGGAAGAACCCTCCATTTATGAATCTGTCCGGGTTCACACAGCAATGCAGACA GGAAGAACAGAAGATGACCTTGTGCCCACAGCACCTTCTCTGGGCACCAAAGAAGGTTACCTCACCAAACAGGGAGGCCTGGTCAAGACC TGGAAAACAAGATGGTTTACTCTGCACAGGAATGAACTGAAATACTTCAAAGACCAGATGAAAGCCTATTCCATCAACTGTGAAAGCTGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DAPP1_ENST00000296414_chr4_100784229_+_COL4A3_ENST00000396578_chr2_228176502_+_3688nt GCAGGCTGCTGTCTCACAGAGCGAGAAGGTGTCAGGAGCAGCCCAGTTGTGTCTCTCTCTCTACCTCTGTGAAGGGCGCGAATGGGCAGA GCAGAACTTCTAGAAGGGAAGATGAGCACCCAGGATCCCTCAGATCTGTGGAGCAGATCCGATGGAGAGGCTGAGCTGCTCCAGGACTTG GGGTGGTATCACGGCAACCTCACACGCCATGCTGCTGAAGCTCTTCTCCTCTCAAATGGATGTGACGGCAGCTACCTTCTGAGGGACAGC AATGAGACCACCGGGCTGTACTCTCTCTCTGTGAGGGCCAAAGATTCTGTTAAACACTTTCATGTTGAATATACTGGATATTCATTTAAA TTTGGCTTTAATGAATTCTCATCTTTGAAGGATTTTGTCAAGCATTTTGCAAATCAGCCTTTGATTGGAAGCGAGACAGGCACTCTGATG GTTCTAAAACATCCCTACCCAAGAAAAGTGGAAGAACCCTCCATTTATGAATCTGTCCGGGTTCACACAGCAATGCAGACAGGAAGAACA GAAGATGACCTTGTGCCCACAGCACCTTCTCTGGGCACCAAAGAAGGTTACCTCACCAAACAGGGAGGCCTGGTCAAGACCTGGAAAACA AGATGGTTTACTCTGCACAGGAATGAACTGAAATACTTCAAAGACCAGATGAAAGCCTATTCCATCAACTGTGAAAGCTGGGGAATTAGA AAAAATAATAAGTCGCTGTCAGGTGTGCATGAAGAAAAGACACTGAAGCTAAAAAAGACAGCAGAACTGCTATTTTTCATCCTAAAGAAC AAAGTAATGACAGAACATGCTGTTATTTAGGTATTTTTCTTTAACCAAACAATATTGCTCCATGATGACTTAGTACAAAGTTTCAATTTG TTTCCCCACAAAACAAAGCAATTCTTTCAAGTCAGTTCTGTGATCTGGGTCTCTAATCTGTGCTGTTTCAAAGTTCTCTGTGGCAAAGCA GCAACTATTCACAAAATATCACCAAAAACCTATTCCACTTACATCCAAGGCACTGTCACTACGGTGATTGTATGAAGTTTGAATGCTGCA AGTTATGAAATATTTGGCCCGCTGGATTCCCACATTTGTCTTCTTTCTGTCTTTAAGACTCAGGGAGGCTAAATCAGTGTTTGATTGCCC CGCCAACCCTTCCTGAAACTTCAGACCCTGGGTAGGGGAAGAGAAGGGGGCATGTGGTATCCTGGAGCATTGTGTATAGAACTGGATTTT CAGACCTGCTGAGGACCGTAAGGCCTGATGGAACACAGAACTGAACTGAGGTTCATGGATTTTCCAGGACTGTTTCAAACATGCCCATTA CTAACGGCAAAAGGGGGATTCCCTGATGGAACCATAATACCCTTGGAAATACTGTATGGTTTTGTTTTGTTTTGTTGGTTTTTAAAGATT TTTGTTTGTTTATTGAATTCATTTCACTGTAGCTCTAAAATCTGCTTGTATTCCAAGCATATAAAATTTTCCCCCTTAGTGAATTAGTTT TAAAATGATATTGTTATATACATACTATGAAATATGTATAACTTTAACTTCTGTTTTACCAGCATACCCACACAAATAACAAGAATACTA CTTATGAAATGTGCACTTTATCCTCATTCCATAAATGTCGGTGCATACCTTATGTAAGGGAGCAGTTCAATAATCCATGAAAGAACTTAA GGCATTTGTTGGTTTATCAGACTCGGAATCTATTTTCTCATTGCTCTGAATATGTCATCACTCTAGGTTTTACAGATTTATTCCTTTGTT ACTTCTCTAATTCTTCCTTTGTAAAAAAAAAAAAAAGCAACACTTTTTATGTTATATGTTGTTCTTACAAACCATACTGAAAGAGTCCAT TGTTTAAAAATCTTAATGTATCAAACTGTATAACTTGGCCGCTGTATGTCTTAAAACCTGCTTTTCAATGTGTTGATACATTCCCAAGGT TACTTAATTCAACTTAACTATCATCTTATTCAGCACCAAGCATGTCCCAGGCACTGTACTAACCTACAGAGATGCTAAGAGAAAAAAAAG ACTTGTTTCTGATCTAATATCCCAGAAAAAGTAACTCATTGCTCTGTTAATAATCTCACATATACAAGTAGCTTCCCTCCCCTCTAGTTT TTTCTTCCTTTTCACTGCTGTTATATTTCATCATGATAATTCAGCAGGCCCAAGTAAAGGTTAAAAATAAGGTCTATGCCTAGGGAAACT CAGGGCTTCTAGTTTCTCTTAGAAAAGCTAAGAGAAGATAAGGTCTGAATAATAGCAGAAAAACCAACATCTACAAAACATTAAACTAGT GTTATACTTGATGATAACACTATTTGATGAGTCTTAGAGTCCAGACACAAAGAGACAAAGCTTTGAAGATGCTTTTTGATCTACCTAGGT GGAGTTGGTGGTGCTGATATTTAAATTCAGGCTACTGCTTCAATCTCAATTGCTTTGTAAGTGAAAAACATGACCCAGAGGACAGCACAG ACTATGGCCATGGCTCACATGGTTTACATCCTTCACTGCTCACGTGTTTGCTGTCAAGCCATTTTTACATCTAAACTAAGATGTGCAGCA TTTCACTTATTTAGATTCACTTAACAAACAAATTTTTCTGCTTTAAAAATGTCTTATTGTCCCAAGTGTACTATAGCGGCATATAGAGCT AGCTAATCTCTACAAACCCTCTGTAGGCCAGTAGTTCTCAAAGTGTGGTCTCTGGAAGAGCAGTATCAGCATCATCTGGGAACTTGTCAC AGATGCAGATTCTAGGGACCACTCCAGACCTACACAATCAGAAACTCTTGGGGGAGGGCCCGAAATATCTATGTTTTACCAAGCCCACCA CATGATTCTGATGTACTCTAAATACTGAGAAAACCTGTTCTAGACAAATACCCAAGCAACAACTCCGCAGGCAGTTACCAAGTACGGCTG GCTACAACTGCTCCATCCGTGCCTCTTTTTAAAGTTCAAACTCACAGGTGACTCTAAGGTTATCTACTTTTACTCATAAGTAAAAGCCCT AGACTGGTGCTAATGTCAAACCACTGGCCTCCACTCAGGCCTCCATCTTCTCATGCCCTCTTACCAGTATTTAACTTCTGAGGAAGACAA GTGATGCTAAAACCTGAAATTCCAATGAAGCCATATGAACAGCTGTTCAGTTGCACTTCTAAGACTTTACTTAGCAGTAAATTATAGCTC ATGTGCATTATTTTCCAGATAACTTAGCTTATGAGTAGCTTATACAATTATGAAGATTTAATATTACAGATAAAATGTAAACTGTTTCTT TAAAATTGGGGCTTCAACTTTGGAATTTCACAGCGTGCTAAAATAACAGATTTCTCAGAAGTCTTTCAGCAAGATAAACATTATTAAGTA ACTTATTTATGAAAGTATTAAAATGCTTACATTTGAACTTGATGGCTAACTTACAAAGATTCTCTATGTATCAAATGTAACTTACTGCGA CTAAACTTAATTTAATATTTACTCTATAACCAAATGAAATATATTTAAAATATATTGAATATTTTATATTGTTATATCCTGACAAGATTA >In-frame_DAPP1_ENST00000512369_chr4_100784229_+_COL4A3_ENST00000396578_chr2_228176502_+_3675nt TCACAGAGCGAGAAGGTGTCAGGAGCAGCCCAGTTGTGTCTCTCTCTCTACCTCTGTGAAGGGCGCGAATGGGCAGAGCAGAACTTCTAG AAGGGAAGATGAGCACCCAGGATCCCTCAGATCTGTGGAGCAGATCCGATGGAGAGGCTGAGCTGCTCCAGGACTTGGGGTGGTATCACG GCAACCTCACACGCCATGCTGCTGAAGCTCTTCTCCTCTCAAATGGATGTGACGGCAGCTACCTTCTGAGGGACAGCAATGAGACCACCG GGCTGTACTCTCTCTCTGTGAGGGCCAAAGATTCTGTTAAACACTTTCATGTTGAATATACTGGATATTCATTTAAATTTGGCTTTAATG AATTCTCATCTTTGAAGGATTTTGTCAAGCATTTTGCAAATCAGCCTTTGATTGGAAGCGAGACAGGCACTCTGATGGTTCTAAAACATC CCTACCCAAGAAAAGTGGAAGAACCCTCCATTTATGAATCTGTCCGGGTTCACACAGCAATGCAGACAGGAAGAACAGAAGATGACCTTG TGCCCACAGCACCTTCTCTGGGCACCAAAGAAGGTTACCTCACCAAACAGGGAGGCCTGGTCAAGACCTGGAAAACAAGATGGTTTACTC TGCACAGGAATGAACTGAAATACTTCAAAGACCAGATGAAAGCCTATTCCATCAACTGTGAAAGCTGGGGAATTAGAAAAAATAATAAGT CGCTGTCAGGTGTGCATGAAGAAAAGACACTGAAGCTAAAAAAGACAGCAGAACTGCTATTTTTCATCCTAAAGAACAAAGTAATGACAG AACATGCTGTTATTTAGGTATTTTTCTTTAACCAAACAATATTGCTCCATGATGACTTAGTACAAAGTTTCAATTTGTTTCCCCACAAAA CAAAGCAATTCTTTCAAGTCAGTTCTGTGATCTGGGTCTCTAATCTGTGCTGTTTCAAAGTTCTCTGTGGCAAAGCAGCAACTATTCACA AAATATCACCAAAAACCTATTCCACTTACATCCAAGGCACTGTCACTACGGTGATTGTATGAAGTTTGAATGCTGCAAGTTATGAAATAT TTGGCCCGCTGGATTCCCACATTTGTCTTCTTTCTGTCTTTAAGACTCAGGGAGGCTAAATCAGTGTTTGATTGCCCCGCCAACCCTTCC TGAAACTTCAGACCCTGGGTAGGGGAAGAGAAGGGGGCATGTGGTATCCTGGAGCATTGTGTATAGAACTGGATTTTCAGACCTGCTGAG GACCGTAAGGCCTGATGGAACACAGAACTGAACTGAGGTTCATGGATTTTCCAGGACTGTTTCAAACATGCCCATTACTAACGGCAAAAG GGGGATTCCCTGATGGAACCATAATACCCTTGGAAATACTGTATGGTTTTGTTTTGTTTTGTTGGTTTTTAAAGATTTTTGTTTGTTTAT TGAATTCATTTCACTGTAGCTCTAAAATCTGCTTGTATTCCAAGCATATAAAATTTTCCCCCTTAGTGAATTAGTTTTAAAATGATATTG TTATATACATACTATGAAATATGTATAACTTTAACTTCTGTTTTACCAGCATACCCACACAAATAACAAGAATACTACTTATGAAATGTG CACTTTATCCTCATTCCATAAATGTCGGTGCATACCTTATGTAAGGGAGCAGTTCAATAATCCATGAAAGAACTTAAGGCATTTGTTGGT TTATCAGACTCGGAATCTATTTTCTCATTGCTCTGAATATGTCATCACTCTAGGTTTTACAGATTTATTCCTTTGTTACTTCTCTAATTC TTCCTTTGTAAAAAAAAAAAAAAGCAACACTTTTTATGTTATATGTTGTTCTTACAAACCATACTGAAAGAGTCCATTGTTTAAAAATCT TAATGTATCAAACTGTATAACTTGGCCGCTGTATGTCTTAAAACCTGCTTTTCAATGTGTTGATACATTCCCAAGGTTACTTAATTCAAC TTAACTATCATCTTATTCAGCACCAAGCATGTCCCAGGCACTGTACTAACCTACAGAGATGCTAAGAGAAAAAAAAGACTTGTTTCTGAT CTAATATCCCAGAAAAAGTAACTCATTGCTCTGTTAATAATCTCACATATACAAGTAGCTTCCCTCCCCTCTAGTTTTTTCTTCCTTTTC ACTGCTGTTATATTTCATCATGATAATTCAGCAGGCCCAAGTAAAGGTTAAAAATAAGGTCTATGCCTAGGGAAACTCAGGGCTTCTAGT TTCTCTTAGAAAAGCTAAGAGAAGATAAGGTCTGAATAATAGCAGAAAAACCAACATCTACAAAACATTAAACTAGTGTTATACTTGATG ATAACACTATTTGATGAGTCTTAGAGTCCAGACACAAAGAGACAAAGCTTTGAAGATGCTTTTTGATCTACCTAGGTGGAGTTGGTGGTG CTGATATTTAAATTCAGGCTACTGCTTCAATCTCAATTGCTTTGTAAGTGAAAAACATGACCCAGAGGACAGCACAGACTATGGCCATGG CTCACATGGTTTACATCCTTCACTGCTCACGTGTTTGCTGTCAAGCCATTTTTACATCTAAACTAAGATGTGCAGCATTTCACTTATTTA GATTCACTTAACAAACAAATTTTTCTGCTTTAAAAATGTCTTATTGTCCCAAGTGTACTATAGCGGCATATAGAGCTAGCTAATCTCTAC AAACCCTCTGTAGGCCAGTAGTTCTCAAAGTGTGGTCTCTGGAAGAGCAGTATCAGCATCATCTGGGAACTTGTCACAGATGCAGATTCT AGGGACCACTCCAGACCTACACAATCAGAAACTCTTGGGGGAGGGCCCGAAATATCTATGTTTTACCAAGCCCACCACATGATTCTGATG TACTCTAAATACTGAGAAAACCTGTTCTAGACAAATACCCAAGCAACAACTCCGCAGGCAGTTACCAAGTACGGCTGGCTACAACTGCTC CATCCGTGCCTCTTTTTAAAGTTCAAACTCACAGGTGACTCTAAGGTTATCTACTTTTACTCATAAGTAAAAGCCCTAGACTGGTGCTAA TGTCAAACCACTGGCCTCCACTCAGGCCTCCATCTTCTCATGCCCTCTTACCAGTATTTAACTTCTGAGGAAGACAAGTGATGCTAAAAC CTGAAATTCCAATGAAGCCATATGAACAGCTGTTCAGTTGCACTTCTAAGACTTTACTTAGCAGTAAATTATAGCTCATGTGCATTATTT TCCAGATAACTTAGCTTATGAGTAGCTTATACAATTATGAAGATTTAATATTACAGATAAAATGTAAACTGTTTCTTTAAAATTGGGGCT TCAACTTTGGAATTTCACAGCGTGCTAAAATAACAGATTTCTCAGAAGTCTTTCAGCAAGATAAACATTATTAAGTAACTTATTTATGAA AGTATTAAAATGCTTACATTTGAACTTGATGGCTAACTTACAAAGATTCTCTATGTATCAAATGTAACTTACTGCGACTAAACTTAATTT AATATTTACTCTATAACCAAATGAAATATATTTAAAATATATTGAATATTTTATATTGTTATATCCTGACAAGATTATAATATTTTAATG |
Top |
FusionGenePPI for DAPP1_COL4A3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DAPP1 | ERBB3, HSPA1A, RPL23, FCHSD2, HSD3B7, GSTCD, MYLIP, WDR20, TNFAIP1, ZNHIT1, CNDP2, MGARP, RBP7, TM4SF19, APBB3, PLAGL2 | COL4A3 | MFAP2, VHL, SHMT2, MOV10 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DAPP1_COL4A3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DAPP1_COL4A3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DAPP1 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Tgene | COL4A3 | C1567744 | Alport Syndrome, Autosomal Recessive | 2 | ORPHANET;UNIPROT |
| Tgene | COL4A3 | C0027706 | Hereditary nephritis | 1 | CTD_human |
| Tgene | COL4A3 | C0241908 | Hematuria, Benign Familial | 1 | CTD_human;UNIPROT |
| Tgene | COL4A3 | C1567743 | Alport Syndrome, Autosomal Dominant | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|