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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9297

FusionGeneSummary for DAPK3_NFATC1

check button Fusion gene summary
Fusion gene informationFusion gene name: DAPK3_NFATC1
Fusion gene ID: 9297
HgeneTgene
Gene symbol

DAPK3

NFATC1

Gene ID

1613

4772

Gene namedeath associated protein kinase 3nuclear factor of activated T cells 1
SynonymsDLK|ZIP|ZIPKNF-ATC|NF-ATc1.2|NFAT2|NFATc
Cytomap

19p13.3

18q23

Type of geneprotein-codingprotein-coding
Descriptiondeath-associated protein kinase 3DAP kinase 3DAP-like kinaseMYPT1 kinaseZIP-kinasezipper-interacting protein kinasenuclear factor of activated T-cells, cytoplasmic 1NFAT transcription complex cytosolic componentnuclear factor of activated T-cells 'c'nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Modification date2018052320180527
UniProtAcc

O43293

O95644

Ensembl transtripts involved in fusion geneENST00000545797, ENST00000301264, 
ENST00000253506, ENST00000591814, 
ENST00000397790, ENST00000587635, 
ENST00000427363, ENST00000542384, 
ENST00000318065, ENST00000545796, 
ENST00000592223, ENST00000329101, 
ENST00000586434, ENST00000590172, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 5=180
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAPK3 [Title/Abstract] AND NFATC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAPK3

GO:0006468

protein phosphorylation

10356987

HgeneDAPK3

GO:0006915

apoptotic process

10580117

HgeneDAPK3

GO:0017148

negative regulation of translation

18995835

HgeneDAPK3

GO:0035556

intracellular signal transduction

10356987

HgeneDAPK3

GO:0043065

positive regulation of apoptotic process

21487036

HgeneDAPK3

GO:0046777

protein autophosphorylation

18239682

HgeneDAPK3

GO:0051893

regulation of focal adhesion assembly

23454120

HgeneDAPK3

GO:0071346

cellular response to interferon-gamma

18995835

HgeneDAPK3

GO:2000249

regulation of actin cytoskeleton reorganization

23454120

TgeneNFATC1

GO:0033173

calcineurin-NFAT signaling cascade

14979875

TgeneNFATC1

GO:0035556

intracellular signal transduction

14749367

TgeneNFATC1

GO:0045893

positive regulation of transcription, DNA-templated

14749367|14979875

TgeneNFATC1

GO:0045944

positive regulation of transcription by RNA polymerase II

14979875

TgeneNFATC1

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

23853098


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI045301DAPK3chr19

3964370

+NFATC1chr18

77272307

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000545797ENST00000253506DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000591814DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000397790DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000587635DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000427363DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000542384DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000318065DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000545796DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000592223DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000329101DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000586434DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000545797ENST00000590172DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000253506DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000591814DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000397790DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000587635DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000427363DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000542384DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000318065DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000545796DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000592223DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000329101DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000586434DAPK3chr19

3964370

+NFATC1chr18

77272307

-
intron-intronENST00000301264ENST00000590172DAPK3chr19

3964370

+NFATC1chr18

77272307

-

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FusionProtFeatures for DAPK3_NFATC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAPK3

O43293

NFATC1

O95644

Serine/threonine kinase which is involved in theregulation of apoptosis, autophagy, transcription, translation andactin cytoskeleton reorganization. Involved in the regulation ofsmooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagiccell deaths signal, depending on the cellular setting. Involved inregulation of starvation-induced autophagy. Regulates myosinphosphorylation in both smooth muscle and non-muscle cells. Insmooth muscle, regulates myosin either directly by phosphorylatingMYL12B and MYL9 or through inhibition of smooth muscle myosinphosphatase (SMPP1M) via phosphorylation of PPP1R12A; theinhibition of SMPP1M functions to enhance muscle responsiveness toCa(2+) and promote a contractile state. Phosphorylates MYL12B innon-muscle cells leading to reorganization of actin cytoskeleton.Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B.Overexpression leads to condensation of actin stress fibers intothick bundles. Involved in actin filament focal adhesion dynamics.The function in both reorganization of actin cytoskeleton andfocal adhesion dissolution is modulated by RhoD. Positivelyregulates canonical Wnt/beta-catenin signaling through interactionwith NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' uponinterferon-gamma activation which is causing RPL13A release fromthe ribosome, RPL13A association with the GAIT complex and itssubsequent involvement in transcript-selective translationinhibition. Enhances transcription from AR-responsive promoters ina hormone- and kinase-dependent manner. Involved in regulation ofcell cycle progression and cell proliferation. May be a tumorsuppressor. {ECO:0000269|PubMed:10356987,ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833,ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528,ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639,ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456,ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835,ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167,ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036,ECO:0000269|PubMed:23454120}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAPK3_NFATC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAPK3_NFATC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAPK3_NFATC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNFATC1O95644DB00852PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1small moleculeapproved

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RelatedDiseases for DAPK3_NFATC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource