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Fusion gene ID: 9297 |
FusionGeneSummary for DAPK3_NFATC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DAPK3_NFATC1 | Fusion gene ID: 9297 | Hgene | Tgene | Gene symbol | DAPK3 | NFATC1 | Gene ID | 1613 | 4772 |
| Gene name | death associated protein kinase 3 | nuclear factor of activated T cells 1 | |
| Synonyms | DLK|ZIP|ZIPK | NF-ATC|NF-ATc1.2|NFAT2|NFATc | |
| Cytomap | 19p13.3 | 18q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | death-associated protein kinase 3DAP kinase 3DAP-like kinaseMYPT1 kinaseZIP-kinasezipper-interacting protein kinase | nuclear factor of activated T-cells, cytoplasmic 1NFAT transcription complex cytosolic componentnuclear factor of activated T-cells 'c'nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | O43293 | O95644 | |
| Ensembl transtripts involved in fusion gene | ENST00000545797, ENST00000301264, | ENST00000253506, ENST00000591814, ENST00000397790, ENST00000587635, ENST00000427363, ENST00000542384, ENST00000318065, ENST00000545796, ENST00000592223, ENST00000329101, ENST00000586434, ENST00000590172, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 5=180 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DAPK3 [Title/Abstract] AND NFATC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DAPK3 | GO:0006468 | protein phosphorylation | 10356987 |
| Hgene | DAPK3 | GO:0006915 | apoptotic process | 10580117 |
| Hgene | DAPK3 | GO:0017148 | negative regulation of translation | 18995835 |
| Hgene | DAPK3 | GO:0035556 | intracellular signal transduction | 10356987 |
| Hgene | DAPK3 | GO:0043065 | positive regulation of apoptotic process | 21487036 |
| Hgene | DAPK3 | GO:0046777 | protein autophosphorylation | 18239682 |
| Hgene | DAPK3 | GO:0051893 | regulation of focal adhesion assembly | 23454120 |
| Hgene | DAPK3 | GO:0071346 | cellular response to interferon-gamma | 18995835 |
| Hgene | DAPK3 | GO:2000249 | regulation of actin cytoskeleton reorganization | 23454120 |
| Tgene | NFATC1 | GO:0033173 | calcineurin-NFAT signaling cascade | 14979875 |
| Tgene | NFATC1 | GO:0035556 | intracellular signal transduction | 14749367 |
| Tgene | NFATC1 | GO:0045893 | positive regulation of transcription, DNA-templated | 14749367|14979875 |
| Tgene | NFATC1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14979875 |
| Tgene | NFATC1 | GO:1905064 | negative regulation of vascular smooth muscle cell differentiation | 23853098 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI045301 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000545797 | ENST00000253506 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000591814 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000397790 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000587635 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000427363 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000542384 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000318065 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000545796 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000592223 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000329101 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000586434 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000545797 | ENST00000590172 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000253506 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000591814 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000397790 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000587635 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000427363 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000542384 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000318065 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000545796 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000592223 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000329101 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000586434 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
| intron-intron | ENST00000301264 | ENST00000590172 | DAPK3 | chr19 | 3964370 | + | NFATC1 | chr18 | 77272307 | - |
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FusionProtFeatures for DAPK3_NFATC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DAPK3 | NFATC1 |
| Serine/threonine kinase which is involved in theregulation of apoptosis, autophagy, transcription, translation andactin cytoskeleton reorganization. Involved in the regulation ofsmooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagiccell deaths signal, depending on the cellular setting. Involved inregulation of starvation-induced autophagy. Regulates myosinphosphorylation in both smooth muscle and non-muscle cells. Insmooth muscle, regulates myosin either directly by phosphorylatingMYL12B and MYL9 or through inhibition of smooth muscle myosinphosphatase (SMPP1M) via phosphorylation of PPP1R12A; theinhibition of SMPP1M functions to enhance muscle responsiveness toCa(2+) and promote a contractile state. Phosphorylates MYL12B innon-muscle cells leading to reorganization of actin cytoskeleton.Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B.Overexpression leads to condensation of actin stress fibers intothick bundles. Involved in actin filament focal adhesion dynamics.The function in both reorganization of actin cytoskeleton andfocal adhesion dissolution is modulated by RhoD. Positivelyregulates canonical Wnt/beta-catenin signaling through interactionwith NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' uponinterferon-gamma activation which is causing RPL13A release fromthe ribosome, RPL13A association with the GAIT complex and itssubsequent involvement in transcript-selective translationinhibition. Enhances transcription from AR-responsive promoters ina hormone- and kinase-dependent manner. Involved in regulation ofcell cycle progression and cell proliferation. May be a tumorsuppressor. {ECO:0000269|PubMed:10356987,ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833,ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528,ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639,ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456,ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835,ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167,ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036,ECO:0000269|PubMed:23454120}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DAPK3_NFATC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DAPK3_NFATC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DAPK3_NFATC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NFATC1 | O95644 | DB00852 | Pseudoephedrine | Nuclear factor of activated T-cells, cytoplasmic 1 | small molecule | approved |
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RelatedDiseases for DAPK3_NFATC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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