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Fusion gene ID: 9296 |
FusionGeneSummary for DAPK2_WDR1 |
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Fusion gene information | Fusion gene name: DAPK2_WDR1 | Fusion gene ID: 9296 | Hgene | Tgene | Gene symbol | DAPK2 | WDR1 | Gene ID | 23604 | 9948 |
Gene name | death associated protein kinase 2 | WD repeat domain 1 | |
Synonyms | DRP-1|DRP1 | AIP1|HEL-S-52|NORI-1 | |
Cytomap | 15q22.31 | 4p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | death-associated protein kinase 2DAP kinase 2DAP-kinase-related protein 1 beta isoform | WD repeat-containing protein 1actin-interacting protein 1epididymis secretory protein Li 52 | |
Modification date | 20180526 | 20180523 | |
UniProtAcc | Q9UIK4 | O75083 | |
Ensembl transtripts involved in fusion gene | ENST00000261891, ENST00000457488, ENST00000558069, ENST00000558482, | ENST00000499869, ENST00000382451, ENST00000382452, ENST00000515743, ENST00000502702, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 6 X 2=36 |
# samples | 9 | 6 | |
** MAII score | log2(9/100*10)=-0.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DAPK2 [Title/Abstract] AND WDR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DAPK2 | GO:0006468 | protein phosphorylation | 10376525 |
Hgene | DAPK2 | GO:0035556 | intracellular signal transduction | 10376525 |
Tgene | WDR1 | GO:0030834 | regulation of actin filament depolymerization | 15629458 |
Tgene | WDR1 | GO:0043297 | apical junction assembly | 25792565 |
Tgene | WDR1 | GO:0045199 | maintenance of epithelial cell apical/basal polarity | 25792565 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-39-5011-01A | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000261891 | ENST00000499869 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000261891 | ENST00000382451 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000261891 | ENST00000382452 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-5UTR | ENST00000261891 | ENST00000515743 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-5UTR | ENST00000261891 | ENST00000502702 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000457488 | ENST00000499869 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000457488 | ENST00000382451 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000457488 | ENST00000382452 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-5UTR | ENST00000457488 | ENST00000515743 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-5UTR | ENST00000457488 | ENST00000502702 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000558069 | ENST00000499869 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000558069 | ENST00000382451 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000558069 | ENST00000382452 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-5UTR | ENST00000558069 | ENST00000515743 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-5UTR | ENST00000558069 | ENST00000502702 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000558482 | ENST00000499869 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000558482 | ENST00000382451 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-3CDS | ENST00000558482 | ENST00000382452 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-5UTR | ENST00000558482 | ENST00000515743 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
intron-5UTR | ENST00000558482 | ENST00000502702 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
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FusionProtFeatures for DAPK2_WDR1 |
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Hgene | Tgene |
DAPK2 | WDR1 |
Calcium/calmodulin-dependent serine/threonine kinaseinvolved in multiple cellular signaling pathways that trigger cellsurvival, apoptosis, and autophagy. Regulates both type Iapoptotic and type II autophagic cell death signals, depending onthe cellular setting. The former is caspase-dependent, while thelatter is caspase-independent and is characterized by theaccumulation of autophagic vesicles. Acts as a mediator of anoikisand a suppressor of beta-catenin-dependent anchorage-independentgrowth of malignant epithelial cells. May play a role ingranulocytic maturation (PubMed:17347302). Regulates granulocyticmotility by controlling cell spreading and polarization(PubMed:24163421). {ECO:0000269|PubMed:17347302,ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}. Isoform 2 is not regulated by calmodulin. It canphosphorylate MYL9. It can induce membrane blebbing and autophagiccell death. | Induces disassembly of actin filaments in conjunctionwith ADF/cofilin family proteins (PubMed:15629458). Enhancescofilin-mediated actin severing (By similarity). Involved incytokinesis. Involved in chemotactic cell migration by restrictinglamellipodial membrane protrusions (PubMed:18494608). Involved inmyocardium sarcomere organization. Required for cardiomyocytegrowth and maintenance (By similarity). Involved in megakaryocytematuration and platelet shedding. Required for the establishmentof planar cell polarity (PCP) during follicular epitheliumdevelopment and for cell shape changes during PCP; the functionseems to implicate cooperation with CFL1 and/or DSTN/ADF. Involvedin the generation/maintenance of cortical tension (By similarity).Involved in assembly and maintenance of epithelial apical celljunctions and plays a role in the organization of theperijunctional actomyosin belt (PubMed:25792565).{ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2,ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608,ECO:0000269|PubMed:25792565}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DAPK2_WDR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DAPK2_WDR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DAPK2 | DAPK2, APP, FAM9B, LLGL2, RACGAP1, TUBGCP5, KLC3 | WDR1 | GRB2, CSNK2B, ISG15, CDK2, TXNDC17, UBE2K, TYMS, TXN, DIS3, UBE2D1, KEAP1, BIRC2, BIRC3, BAG3, SKIV2L, EIF5A, HSPE1, RBBP7, ADSS, CBX3, MAPK14, MVD, NAGK, NME1, OXCT1, PTMS, C11orf58, TALDO1, THOP1, CUL3, MOV10, NXF1, ABCE1, AMBRA1, ATP6AP2, CALR, CFL1, CFL2, DSTN, ENO1, ENO2, GOT1, GPI, IFI30, ITPA, LACTB2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MSI2, NME1-NME2, NME2, PABPC4, PCBD1, PPIH, PRDX6, PSMG4, TKT, C11orf54, CTBP1, CTH, EZR, GALE, GGCT, GMPPB, GSTO2, MSN, RGN, SCLY, UAP1, UAP1L1, NTRK1, HSPB2, PPME1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, USP7, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, NUP107, MYO19, MYO18A, U2AF2, POTEE, ATRX, TRIM25, YAP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DAPK2_WDR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DAPK2_WDR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | WDR1 | C0021368 | Inflammation | 1 | CTD_human |
Tgene | WDR1 | C0029456 | Osteoporosis | 1 | CTD_human |
Tgene | WDR1 | C0040034 | Thrombocytopenia | 1 | CTD_human |