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Fusion gene ID: 9296 |
FusionGeneSummary for DAPK2_WDR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DAPK2_WDR1 | Fusion gene ID: 9296 | Hgene | Tgene | Gene symbol | DAPK2 | WDR1 | Gene ID | 23604 | 9948 |
| Gene name | death associated protein kinase 2 | WD repeat domain 1 | |
| Synonyms | DRP-1|DRP1 | AIP1|HEL-S-52|NORI-1 | |
| Cytomap | 15q22.31 | 4p16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | death-associated protein kinase 2DAP kinase 2DAP-kinase-related protein 1 beta isoform | WD repeat-containing protein 1actin-interacting protein 1epididymis secretory protein Li 52 | |
| Modification date | 20180526 | 20180523 | |
| UniProtAcc | Q9UIK4 | O75083 | |
| Ensembl transtripts involved in fusion gene | ENST00000261891, ENST00000457488, ENST00000558069, ENST00000558482, | ENST00000499869, ENST00000382451, ENST00000382452, ENST00000515743, ENST00000502702, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 6 X 2=36 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/100*10)=-0.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DAPK2 [Title/Abstract] AND WDR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DAPK2 | GO:0006468 | protein phosphorylation | 10376525 |
| Hgene | DAPK2 | GO:0035556 | intracellular signal transduction | 10376525 |
| Tgene | WDR1 | GO:0030834 | regulation of actin filament depolymerization | 15629458 |
| Tgene | WDR1 | GO:0043297 | apical junction assembly | 25792565 |
| Tgene | WDR1 | GO:0045199 | maintenance of epithelial cell apical/basal polarity | 25792565 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-39-5011-01A | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000261891 | ENST00000499869 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000261891 | ENST00000382451 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000261891 | ENST00000382452 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-5UTR | ENST00000261891 | ENST00000515743 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-5UTR | ENST00000261891 | ENST00000502702 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000457488 | ENST00000499869 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000457488 | ENST00000382451 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000457488 | ENST00000382452 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-5UTR | ENST00000457488 | ENST00000515743 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-5UTR | ENST00000457488 | ENST00000502702 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000558069 | ENST00000499869 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000558069 | ENST00000382451 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000558069 | ENST00000382452 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-5UTR | ENST00000558069 | ENST00000515743 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-5UTR | ENST00000558069 | ENST00000502702 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000558482 | ENST00000499869 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000558482 | ENST00000382451 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-3CDS | ENST00000558482 | ENST00000382452 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-5UTR | ENST00000558482 | ENST00000515743 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
| intron-5UTR | ENST00000558482 | ENST00000502702 | DAPK2 | chr15 | 64222631 | - | WDR1 | chr4 | 10086115 | - |
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FusionProtFeatures for DAPK2_WDR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DAPK2 | WDR1 |
| Calcium/calmodulin-dependent serine/threonine kinaseinvolved in multiple cellular signaling pathways that trigger cellsurvival, apoptosis, and autophagy. Regulates both type Iapoptotic and type II autophagic cell death signals, depending onthe cellular setting. The former is caspase-dependent, while thelatter is caspase-independent and is characterized by theaccumulation of autophagic vesicles. Acts as a mediator of anoikisand a suppressor of beta-catenin-dependent anchorage-independentgrowth of malignant epithelial cells. May play a role ingranulocytic maturation (PubMed:17347302). Regulates granulocyticmotility by controlling cell spreading and polarization(PubMed:24163421). {ECO:0000269|PubMed:17347302,ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}. Isoform 2 is not regulated by calmodulin. It canphosphorylate MYL9. It can induce membrane blebbing and autophagiccell death. | Induces disassembly of actin filaments in conjunctionwith ADF/cofilin family proteins (PubMed:15629458). Enhancescofilin-mediated actin severing (By similarity). Involved incytokinesis. Involved in chemotactic cell migration by restrictinglamellipodial membrane protrusions (PubMed:18494608). Involved inmyocardium sarcomere organization. Required for cardiomyocytegrowth and maintenance (By similarity). Involved in megakaryocytematuration and platelet shedding. Required for the establishmentof planar cell polarity (PCP) during follicular epitheliumdevelopment and for cell shape changes during PCP; the functionseems to implicate cooperation with CFL1 and/or DSTN/ADF. Involvedin the generation/maintenance of cortical tension (By similarity).Involved in assembly and maintenance of epithelial apical celljunctions and plays a role in the organization of theperijunctional actomyosin belt (PubMed:25792565).{ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2,ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608,ECO:0000269|PubMed:25792565}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DAPK2_WDR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DAPK2_WDR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DAPK2 | DAPK2, APP, FAM9B, LLGL2, RACGAP1, TUBGCP5, KLC3 | WDR1 | GRB2, CSNK2B, ISG15, CDK2, TXNDC17, UBE2K, TYMS, TXN, DIS3, UBE2D1, KEAP1, BIRC2, BIRC3, BAG3, SKIV2L, EIF5A, HSPE1, RBBP7, ADSS, CBX3, MAPK14, MVD, NAGK, NME1, OXCT1, PTMS, C11orf58, TALDO1, THOP1, CUL3, MOV10, NXF1, ABCE1, AMBRA1, ATP6AP2, CALR, CFL1, CFL2, DSTN, ENO1, ENO2, GOT1, GPI, IFI30, ITPA, LACTB2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MSI2, NME1-NME2, NME2, PABPC4, PCBD1, PPIH, PRDX6, PSMG4, TKT, C11orf54, CTBP1, CTH, EZR, GALE, GGCT, GMPPB, GSTO2, MSN, RGN, SCLY, UAP1, UAP1L1, NTRK1, HSPB2, PPME1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, USP7, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, NUP107, MYO19, MYO18A, U2AF2, POTEE, ATRX, TRIM25, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DAPK2_WDR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DAPK2_WDR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | WDR1 | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | WDR1 | C0029456 | Osteoporosis | 1 | CTD_human |
| Tgene | WDR1 | C0040034 | Thrombocytopenia | 1 | CTD_human |
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