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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9296

FusionGeneSummary for DAPK2_WDR1

check button Fusion gene summary
Fusion gene informationFusion gene name: DAPK2_WDR1
Fusion gene ID: 9296
HgeneTgene
Gene symbol

DAPK2

WDR1

Gene ID

23604

9948

Gene namedeath associated protein kinase 2WD repeat domain 1
SynonymsDRP-1|DRP1AIP1|HEL-S-52|NORI-1
Cytomap

15q22.31

4p16.1

Type of geneprotein-codingprotein-coding
Descriptiondeath-associated protein kinase 2DAP kinase 2DAP-kinase-related protein 1 beta isoformWD repeat-containing protein 1actin-interacting protein 1epididymis secretory protein Li 52
Modification date2018052620180523
UniProtAcc

Q9UIK4

O75083

Ensembl transtripts involved in fusion geneENST00000261891, ENST00000457488, 
ENST00000558069, ENST00000558482, 
ENST00000499869, ENST00000382451, 
ENST00000382452, ENST00000515743, 
ENST00000502702, 
Fusion gene scores* DoF score5 X 5 X 4=1003 X 6 X 2=36
# samples 96
** MAII scorelog2(9/100*10)=-0.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DAPK2 [Title/Abstract] AND WDR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAPK2

GO:0006468

protein phosphorylation

10376525

HgeneDAPK2

GO:0035556

intracellular signal transduction

10376525

TgeneWDR1

GO:0030834

regulation of actin filament depolymerization

15629458

TgeneWDR1

GO:0043297

apical junction assembly

25792565

TgeneWDR1

GO:0045199

maintenance of epithelial cell apical/basal polarity

25792565


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-39-5011-01ADAPK2chr15

64222631

-WDR1chr4

10086115

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000261891ENST00000499869DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000261891ENST00000382451DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000261891ENST00000382452DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-5UTRENST00000261891ENST00000515743DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-5UTRENST00000261891ENST00000502702DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000457488ENST00000499869DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000457488ENST00000382451DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000457488ENST00000382452DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-5UTRENST00000457488ENST00000515743DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-5UTRENST00000457488ENST00000502702DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000558069ENST00000499869DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000558069ENST00000382451DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000558069ENST00000382452DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-5UTRENST00000558069ENST00000515743DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-5UTRENST00000558069ENST00000502702DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000558482ENST00000499869DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000558482ENST00000382451DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-3CDSENST00000558482ENST00000382452DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-5UTRENST00000558482ENST00000515743DAPK2chr15

64222631

-WDR1chr4

10086115

-
intron-5UTRENST00000558482ENST00000502702DAPK2chr15

64222631

-WDR1chr4

10086115

-

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FusionProtFeatures for DAPK2_WDR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAPK2

Q9UIK4

WDR1

O75083

Calcium/calmodulin-dependent serine/threonine kinaseinvolved in multiple cellular signaling pathways that trigger cellsurvival, apoptosis, and autophagy. Regulates both type Iapoptotic and type II autophagic cell death signals, depending onthe cellular setting. The former is caspase-dependent, while thelatter is caspase-independent and is characterized by theaccumulation of autophagic vesicles. Acts as a mediator of anoikisand a suppressor of beta-catenin-dependent anchorage-independentgrowth of malignant epithelial cells. May play a role ingranulocytic maturation (PubMed:17347302). Regulates granulocyticmotility by controlling cell spreading and polarization(PubMed:24163421). {ECO:0000269|PubMed:17347302,ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}. Isoform 2 is not regulated by calmodulin. It canphosphorylate MYL9. It can induce membrane blebbing and autophagiccell death. Induces disassembly of actin filaments in conjunctionwith ADF/cofilin family proteins (PubMed:15629458). Enhancescofilin-mediated actin severing (By similarity). Involved incytokinesis. Involved in chemotactic cell migration by restrictinglamellipodial membrane protrusions (PubMed:18494608). Involved inmyocardium sarcomere organization. Required for cardiomyocytegrowth and maintenance (By similarity). Involved in megakaryocytematuration and platelet shedding. Required for the establishmentof planar cell polarity (PCP) during follicular epitheliumdevelopment and for cell shape changes during PCP; the functionseems to implicate cooperation with CFL1 and/or DSTN/ADF. Involvedin the generation/maintenance of cortical tension (By similarity).Involved in assembly and maintenance of epithelial apical celljunctions and plays a role in the organization of theperijunctional actomyosin belt (PubMed:25792565).{ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2,ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608,ECO:0000269|PubMed:25792565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAPK2_WDR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAPK2_WDR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DAPK2DAPK2, APP, FAM9B, LLGL2, RACGAP1, TUBGCP5, KLC3WDR1GRB2, CSNK2B, ISG15, CDK2, TXNDC17, UBE2K, TYMS, TXN, DIS3, UBE2D1, KEAP1, BIRC2, BIRC3, BAG3, SKIV2L, EIF5A, HSPE1, RBBP7, ADSS, CBX3, MAPK14, MVD, NAGK, NME1, OXCT1, PTMS, C11orf58, TALDO1, THOP1, CUL3, MOV10, NXF1, ABCE1, AMBRA1, ATP6AP2, CALR, CFL1, CFL2, DSTN, ENO1, ENO2, GOT1, GPI, IFI30, ITPA, LACTB2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MSI2, NME1-NME2, NME2, PABPC4, PCBD1, PPIH, PRDX6, PSMG4, TKT, C11orf54, CTBP1, CTH, EZR, GALE, GGCT, GMPPB, GSTO2, MSN, RGN, SCLY, UAP1, UAP1L1, NTRK1, HSPB2, PPME1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, USP7, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, NUP107, MYO19, MYO18A, U2AF2, POTEE, ATRX, TRIM25, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAPK2_WDR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DAPK2_WDR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWDR1C0021368Inflammation1CTD_human
TgeneWDR1C0029456Osteoporosis1CTD_human
TgeneWDR1C0040034Thrombocytopenia1CTD_human