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Fusion gene ID: 9283 |
FusionGeneSummary for DAP3_TIPRL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DAP3_TIPRL | Fusion gene ID: 9283 | Hgene | Tgene | Gene symbol | DAP3 | TIPRL | Gene ID | 58512 | 261726 |
| Gene name | DLG associated protein 3 | TOR signaling pathway regulator | |
| Synonyms | DAP3|SAPAP3 | TIP|TIP41|TIPRL1 | |
| Cytomap | 1p34.3 | 1q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3 | TIP41-like proteinTIP41, TOR signaling pathway regulator-likeputative MAPK-activating protein PM10type 2A-interacting protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P51398 | O75663 | |
| Ensembl transtripts involved in fusion gene | ENST00000471642, ENST00000368336, ENST00000343043, ENST00000496863, ENST00000535183, ENST00000421487, ENST00000465375, | ENST00000367833, ENST00000367830, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 3 X 2=18 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DAP3 [Title/Abstract] AND TIPRL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TIPRL | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 17384681 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-A9SY-01A | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000471642 | ENST00000367833 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000471642 | ENST00000367830 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000368336 | ENST00000367833 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000368336 | ENST00000367830 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000343043 | ENST00000367833 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000343043 | ENST00000367830 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| 3UTR-3CDS | ENST00000496863 | ENST00000367833 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| 3UTR-3CDS | ENST00000496863 | ENST00000367830 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000535183 | ENST00000367833 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000535183 | ENST00000367830 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000421487 | ENST00000367833 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000421487 | ENST00000367830 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000465375 | ENST00000367833 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
| In-frame | ENST00000465375 | ENST00000367830 | DAP3 | chr1 | 155679615 | + | TIPRL | chr1 | 168160607 | + |
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FusionProtFeatures for DAP3_TIPRL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DAP3 | TIPRL |
| Involved in mediating interferon-gamma-induced celldeath. | May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalyticactivity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRLcomplex does not show phosphatase activity. Acts as negativeregulator of serine/threonine-protein phosphatase 4 probably byinhibiting the formation of the active PPP4C:PPP4R2 complex; thefunction is proposed to implicate it in DNA damage response bypromoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May playa role in the regulation of ATM/ATR signaling pathway controllingDNA replication and repair. {ECO:0000269|PubMed:17384681,ECO:0000269|PubMed:26717153}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DAP3 | chr1:155679615 | chr1:168160607 | ENST00000343043 | + | 2 | 13 | 128_135 | 15 | 399 | Nucleotide binding | GTP |
| Hgene | >DAP3 | chr1:155679615 | chr1:168160607 | ENST00000368336 | + | 2 | 13 | 128_135 | 15 | 399 | Nucleotide binding | GTP |
| Hgene | >DAP3 | chr1:155679615 | chr1:168160607 | ENST00000421487 | + | 2 | 12 | 128_135 | 15 | 365 | Nucleotide binding | GTP |
| Hgene | >DAP3 | chr1:155679615 | chr1:168160607 | ENST00000535183 | + | 2 | 12 | 128_135 | 15 | 358 | Nucleotide binding | GTP |
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FusionGeneSequence for DAP3_TIPRL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DAP3_ENST00000471642_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_160aa MMLKGITRLISRIHKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYH >In-frame_DAP3_ENST00000471642_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_66aa >In-frame_DAP3_ENST00000368336_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_160aa MMLKGITRLISRIHKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYH >In-frame_DAP3_ENST00000368336_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_66aa >In-frame_DAP3_ENST00000343043_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_160aa MMLKGITRLISRIHKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYH >In-frame_DAP3_ENST00000343043_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_66aa >In-frame_DAP3_ENST00000535183_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_160aa MMLKGITRLISRIHKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYH >In-frame_DAP3_ENST00000535183_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_66aa >In-frame_DAP3_ENST00000421487_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_160aa MMLKGITRLISRIHKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYH >In-frame_DAP3_ENST00000421487_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_66aa >In-frame_DAP3_ENST00000465375_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_160aa MMLKGITRLISRIHKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYH >In-frame_DAP3_ENST00000465375_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_66aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DAP3_ENST00000471642_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_480nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGA GTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCAT GAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCACG GAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGCA >In-frame_DAP3_ENST00000471642_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_198nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCT >In-frame_DAP3_ENST00000368336_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_480nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGA GTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCAT GAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCACG GAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGCA >In-frame_DAP3_ENST00000368336_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_198nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCT >In-frame_DAP3_ENST00000343043_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_480nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGA GTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCAT GAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCACG GAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGCA >In-frame_DAP3_ENST00000343043_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_198nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCT >In-frame_DAP3_ENST00000535183_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_480nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGA GTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCAT GAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCACG GAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGCA >In-frame_DAP3_ENST00000535183_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_198nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCT >In-frame_DAP3_ENST00000421487_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_480nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGA GTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCAT GAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCACG GAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGCA >In-frame_DAP3_ENST00000421487_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_198nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCT >In-frame_DAP3_ENST00000465375_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_480nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGA GTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCAT GAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCACG GAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGCA >In-frame_DAP3_ENST00000465375_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_198nt ATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCC AGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DAP3_ENST00000471642_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_1459nt CAGAGGTCCAGGTCCGGGAGATGACAGTGGCTCCCAGAAAGCCCAGGATTCAATCGCTGAGAGAGTGCTTAGGCCCGAATGCCGGCCCAA ATCGTTCTACTCACCGTGTCGGAGGCCGAGAGCGATGAGAGTACAGGGAAGTGAGGAAGAGGGGGTGGCCGCCAGGCTCCTCCGCTTCCC TGGGTCCACCGCGGATCCCTCCCGCTTGTCAGGAGGCGGCCAGCGGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTC GGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCACGTGCAAGGATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGT TGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCCAGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGA ACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGAGTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAAT TGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCATGAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAG CAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCACGGAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTG TGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGCAGACTCACAAAAAAGTACACAAGTGGAATAAAATGTGATACAACATAT ACTCACTATGGAATCTGACTGGACACCTTGGCTATTTGTAAGGGGTTATTTTTATTATGAGAATTAATTGCCTTGTTTATGTACAGATTT TCTGTAGCCTTAAAGGAAAAAAAAATAAAGATCGTTACAGGCAGGTTTCACTCAACTGCTGTTTGTACTGTCTGTCTTCACATTCATATT CCAGATTTATATTTTCTGGAGTTAAATTTGGATGATTTCTAAATTATCACAAAGTGGGACCTCAGCAGTAGTGATGTGTGTGTCTCATGA GCAGTGAGCACAGTCTGCATTCATCATGAAACACTATCTTCTACCAGGAGGAGGTTAATGTAAATCACCAAATCCCAATGCCTTGTGACT TTCATAGGATTCCTGATCATGCATGTTGATGTACTGGCTCTTCACTTTGGGCTTTCTGATGTTTATTCACACCTTTGGAGAGTTGCAACT TGCCACATACGAAATTAGTCTCATAGTGTAGTGAACTTCAACCCCAAAATTTTAAAAATGTATTTCCCCCCAGTTTTAAATTGCCTTTGA AATTTAAAAAAAAAAAATTTAGACTTAGTACCAGAACCAAAAATACCTAGATTTTTGGAGAACTTATTACATACATAGAAACATGAATAT >In-frame_DAP3_ENST00000471642_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_678nt CAGAGGTCCAGGTCCGGGAGATGACAGTGGCTCCCAGAAAGCCCAGGATTCAATCGCTGAGAGAGTGCTTAGGCCCGAATGCCGGCCCAA ATCGTTCTACTCACCGTGTCGGAGGCCGAGAGCGATGAGAGTACAGGGAAGTGAGGAAGAGGGGGTGGCCGCCAGGCTCCTCCGCTTCCC TGGGTCCACCGCGGATCCCTCCCGCTTGTCAGGAGGCGGCCAGCGGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTC GGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCACGTGCAAGGATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGT TGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCCAGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGA ACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGA GAAGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCCTCCAGCCTGGGCGACAGAGCAAGACTC >In-frame_DAP3_ENST00000368336_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_1270nt GTCGTTTCCTGCCGGATGACCCGACCCTTTTTTGCAGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTA GTCTGGAGAACTAGTCCTCGACTCACGTGCAAGGATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTAC AACAGATCATATAGATACAGAAAAATTGAAAGCCAGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGA TCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGAGTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGT GCTTATCAGAATGAATGACACGAGACTTTACCATGAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTC TAGTTTGATGCATGTTCCACCTTCCCTCTTCACGGAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCT AATATTTCCAGAAAGAATTGATCCTAACCCAGCAGACTCACAAAAAAGTACACAAGTGGAATAAAATGTGATACAACATATACTCACTAT GGAATCTGACTGGACACCTTGGCTATTTGTAAGGGGTTATTTTTATTATGAGAATTAATTGCCTTGTTTATGTACAGATTTTCTGTAGCC TTAAAGGAAAAAAAAATAAAGATCGTTACAGGCAGGTTTCACTCAACTGCTGTTTGTACTGTCTGTCTTCACATTCATATTCCAGATTTA TATTTTCTGGAGTTAAATTTGGATGATTTCTAAATTATCACAAAGTGGGACCTCAGCAGTAGTGATGTGTGTGTCTCATGAGCAGTGAGC ACAGTCTGCATTCATCATGAAACACTATCTTCTACCAGGAGGAGGTTAATGTAAATCACCAAATCCCAATGCCTTGTGACTTTCATAGGA TTCCTGATCATGCATGTTGATGTACTGGCTCTTCACTTTGGGCTTTCTGATGTTTATTCACACCTTTGGAGAGTTGCAACTTGCCACATA CGAAATTAGTCTCATAGTGTAGTGAACTTCAACCCCAAAATTTTAAAAATGTATTTCCCCCCAGTTTTAAATTGCCTTTGAAATTTAAAA AAAAAAAATTTAGACTTAGTACCAGAACCAAAAATACCTAGATTTTTGGAGAACTTATTACATACATAGAAACATGAATATGGTTTACCA >In-frame_DAP3_ENST00000368336_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_489nt GTCGTTTCCTGCCGGATGACCCGACCCTTTTTTGCAGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTA GTCTGGAGAACTAGTCCTCGACTCACGTGCAAGGATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTAC AACAGATCATATAGATACAGAAAAATTGAAAGCCAGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGA TCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAAGCGTGA ACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCCTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCAAA >In-frame_DAP3_ENST00000343043_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_1314nt CCTTTTTTGCAGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCA CGGTGAGGGAATGGACCGACACGGGTATTGTACCGCTGAGGGAAAGGAGCGGGACTCCGGACCTCCAGGAGTGCAAGGATGATGCTGAAA GGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCCAGAGAACAGATT AAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGAGTAATGCCTTCT AGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCATGAGGCTGACAAG ACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCACGGAACCTAATGAA ATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGCAGACTCACAAAAA AGTACACAAGTGGAATAAAATGTGATACAACATATACTCACTATGGAATCTGACTGGACACCTTGGCTATTTGTAAGGGGTTATTTTTAT TATGAGAATTAATTGCCTTGTTTATGTACAGATTTTCTGTAGCCTTAAAGGAAAAAAAAATAAAGATCGTTACAGGCAGGTTTCACTCAA CTGCTGTTTGTACTGTCTGTCTTCACATTCATATTCCAGATTTATATTTTCTGGAGTTAAATTTGGATGATTTCTAAATTATCACAAAGT GGGACCTCAGCAGTAGTGATGTGTGTGTCTCATGAGCAGTGAGCACAGTCTGCATTCATCATGAAACACTATCTTCTACCAGGAGGAGGT TAATGTAAATCACCAAATCCCAATGCCTTGTGACTTTCATAGGATTCCTGATCATGCATGTTGATGTACTGGCTCTTCACTTTGGGCTTT CTGATGTTTATTCACACCTTTGGAGAGTTGCAACTTGCCACATACGAAATTAGTCTCATAGTGTAGTGAACTTCAACCCCAAAATTTTAA AAATGTATTTCCCCCCAGTTTTAAATTGCCTTTGAAATTTAAAAAAAAAAAATTTAGACTTAGTACCAGAACCAAAAATACCTAGATTTT >In-frame_DAP3_ENST00000343043_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_533nt CCTTTTTTGCAGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCA CGGTGAGGGAATGGACCGACACGGGTATTGTACCGCTGAGGGAAAGGAGCGGGACTCCGGACCTCCAGGAGTGCAAGGATGATGCTGAAA GGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCCAGAGAACAGATT AAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCTGGTGGCGGGCAC CTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAAGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGATCGCACCACTGCAC >In-frame_DAP3_ENST00000535183_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_1237nt GCAGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCACGTGCAAG GATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGC CAGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAG AGTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCA TGAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCAC GGAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGC AGACTCACAAAAAAGTACACAAGTGGAATAAAATGTGATACAACATATACTCACTATGGAATCTGACTGGACACCTTGGCTATTTGTAAG GGGTTATTTTTATTATGAGAATTAATTGCCTTGTTTATGTACAGATTTTCTGTAGCCTTAAAGGAAAAAAAAATAAAGATCGTTACAGGC AGGTTTCACTCAACTGCTGTTTGTACTGTCTGTCTTCACATTCATATTCCAGATTTATATTTTCTGGAGTTAAATTTGGATGATTTCTAA ATTATCACAAAGTGGGACCTCAGCAGTAGTGATGTGTGTGTCTCATGAGCAGTGAGCACAGTCTGCATTCATCATGAAACACTATCTTCT ACCAGGAGGAGGTTAATGTAAATCACCAAATCCCAATGCCTTGTGACTTTCATAGGATTCCTGATCATGCATGTTGATGTACTGGCTCTT CACTTTGGGCTTTCTGATGTTTATTCACACCTTTGGAGAGTTGCAACTTGCCACATACGAAATTAGTCTCATAGTGTAGTGAACTTCAAC CCCAAAATTTTAAAAATGTATTTCCCCCCAGTTTTAAATTGCCTTTGAAATTTAAAAAAAAAAAATTTAGACTTAGTACCAGAACCAAAA >In-frame_DAP3_ENST00000535183_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_456nt GCAGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCACGTGCAAG GATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGC CAGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCC TGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAAGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGAT CGCACCACTGCACTCCAGCCCTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAATAAAATAAAATAAAAGAAGTAGAA >In-frame_DAP3_ENST00000421487_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_1237nt GCAGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCACGTGCAAG GATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGC CAGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAG AGTAATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCA TGAGGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCAC GGAACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGC AGACTCACAAAAAAGTACACAAGTGGAATAAAATGTGATACAACATATACTCACTATGGAATCTGACTGGACACCTTGGCTATTTGTAAG GGGTTATTTTTATTATGAGAATTAATTGCCTTGTTTATGTACAGATTTTCTGTAGCCTTAAAGGAAAAAAAAATAAAGATCGTTACAGGC AGGTTTCACTCAACTGCTGTTTGTACTGTCTGTCTTCACATTCATATTCCAGATTTATATTTTCTGGAGTTAAATTTGGATGATTTCTAA ATTATCACAAAGTGGGACCTCAGCAGTAGTGATGTGTGTGTCTCATGAGCAGTGAGCACAGTCTGCATTCATCATGAAACACTATCTTCT ACCAGGAGGAGGTTAATGTAAATCACCAAATCCCAATGCCTTGTGACTTTCATAGGATTCCTGATCATGCATGTTGATGTACTGGCTCTT CACTTTGGGCTTTCTGATGTTTATTCACACCTTTGGAGAGTTGCAACTTGCCACATACGAAATTAGTCTCATAGTGTAGTGAACTTCAAC CCCAAAATTTTAAAAATGTATTTCCCCCCAGTTTTAAATTGCCTTTGAAATTTAAAAAAAAAAAATTTAGACTTAGTACCAGAACCAAAA >In-frame_DAP3_ENST00000421487_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_456nt GCAGTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCACGTGCAAG GATGATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGC CAGAGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCC TGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAAGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGAT CGCACCACTGCACTCCAGCCCTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAATAAAATAAAATAAAAGAAGTAGAA >In-frame_DAP3_ENST00000465375_chr1_155679615_+_TIPRL_ENST00000367833_chr1_168160607_+_1234nt GTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCACGTGCAAGGAT GATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCCAG AGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTAGAGT AATGCCTTCTAGCTTTTTCCTGCTGTTGCGGTTTTTCTTGAGAATTGATGGGGTGCTTATCAGAATGAATGACACGAGACTTTACCATGA GGCTGACAAGACCTACATGTTACGAGAATATACGTCACGAGAAAGCAAAATTTCTAGTTTGATGCATGTTCCACCTTCCCTCTTCACGGA ACCTAATGAAATATCCCAGTATTTACCAATAAAGGAAGCAGTTTGTGAGAAGCTAATATTTCCAGAAAGAATTGATCCTAACCCAGCAGA CTCACAAAAAAGTACACAAGTGGAATAAAATGTGATACAACATATACTCACTATGGAATCTGACTGGACACCTTGGCTATTTGTAAGGGG TTATTTTTATTATGAGAATTAATTGCCTTGTTTATGTACAGATTTTCTGTAGCCTTAAAGGAAAAAAAAATAAAGATCGTTACAGGCAGG TTTCACTCAACTGCTGTTTGTACTGTCTGTCTTCACATTCATATTCCAGATTTATATTTTCTGGAGTTAAATTTGGATGATTTCTAAATT ATCACAAAGTGGGACCTCAGCAGTAGTGATGTGTGTGTCTCATGAGCAGTGAGCACAGTCTGCATTCATCATGAAACACTATCTTCTACC AGGAGGAGGTTAATGTAAATCACCAAATCCCAATGCCTTGTGACTTTCATAGGATTCCTGATCATGCATGTTGATGTACTGGCTCTTCAC TTTGGGCTTTCTGATGTTTATTCACACCTTTGGAGAGTTGCAACTTGCCACATACGAAATTAGTCTCATAGTGTAGTGAACTTCAACCCC AAAATTTTAAAAATGTATTTCCCCCCAGTTTTAAATTGCCTTTGAAATTTAAAAAAAAAAAATTTAGACTTAGTACCAGAACCAAAAATA >In-frame_DAP3_ENST00000465375_chr1_155679615_+_TIPRL_ENST00000367830_chr1_168160607_+_453nt GTCTCAGGACGGGCGCTTTGGAGCCGGCCCCAGGCAGCGTGTGTCGGTCGCCTAGTCTGGAGAACTAGTCCTCGACTCACGTGCAAGGAT GATGCTGAAAGGAATAACAAGGCTTATCTCTAGGATCCATAAGGTTGTACCTACAACAGATCATATAGATACAGAAAAATTGAAAGCCAG AGAACAGATTAAGTTTTTTGAAGAAGTTCTCCTTTTTGAGGATGAACTTCATGATCATGGAGTTTCAAGCCTGAGTGTGAAGATTCCTGG TGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAAGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAGATCGC ACCACTGCACTCCAGCCCTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAATAAAATAAAATAAAAGAAGTAGAAAAC |
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FusionGenePPI for DAP3_TIPRL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DAP3 | CNBP, NR3C1, PPARA, HSP90AA1, HIF1A, AHR, ESR1, ESR2, PGR, THRA, AR, DAP3, TNFRSF10A, TNFRSF25, FADD, UBC, ICT1, DYRK2, MRPS27, STOML2, COX5A, YME1L1, C1QBP, SOX2, TARDBP, PARK2, GRSF1, CEP250, HAUS2, VCP, FBXW11, BTRC, TRA2A, RPL6, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS35, MRPS10, WDFY2, MTIF2, PNMA6A, MRPS5, NTRK1, PTCD3, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS28, MRPS9, LYST, COL4A5, CSNK1D, MBNL1, PYCR1, HNRNPU, MAGEA1, AP3D1, POC1A, MRPS11, ZNF746, DUSP11, MRPS34, MRPS15, AURKAIP1, RRS1, ZBTB48, E4F1, BHLHA15, FGF8, ZNF331, U2AF2, ZNF324B, ZNF133, ZNF408, SNRNP70, CCDC59, GLTSCR2, RBM3, NCL, DLD | TIPRL | PPP4C, PPP4R2, PPP2CB, PPP6C, CUL3, APP, PRDX1, PRDX2, SORD, SSU72, XPNPEP1, ATP6V1A, METTL21B, LMNA, HUWE1, PPP2CA, IGBP1, ARHGAP44, MCMBP, NPEPL1, SH3BP1, ACAD10, COMMD2, COMMD4, CORO1B, CORO1C, CSE1L, EIF4A3, GDA, GOLPH3, IARS, LARS, MSH2, PLCG1, PPP6R3, SRM, TPP2, UCHL5, UROD, NTRK1, DUSP8, FUCA1, ITLN1, PTPDC1, DYNLT1, TCTEX1D2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | TIPRL | chr1:155679615 | chr1:168160607 | ENST00000367830 | + | 2 | 5 | 173_272 | 128 | 179 | PPP2CA |
| Tgene | TIPRL | chr1:155679615 | chr1:168160607 | ENST00000367833 | + | 2 | 7 | 173_272 | 128 | 273 | PPP2CA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DAP3_TIPRL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DAP3_TIPRL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DAP3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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