	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 9282

FusionGeneSummary for DAP3_RPRD2

Fusion gene summary

Fusion gene information	Fusion gene name: DAP3_RPRD2
	Fusion gene ID: 9282
		Hgene	Tgene
	Gene symbol	DAP3	RPRD2
	Gene ID	58512	23248
	Gene name	DLG associated protein 3	regulation of nuclear pre-mRNA domain containing 2
	Synonyms	DAP3\|SAPAP3	HSPC099\|KIAA0460
	Cytomap	1p34.3	1q21.2
	Type of gene	protein-coding	protein-coding
	Description	disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3	regulation of nuclear pre-mRNA domain-containing protein 2
	Modification date	20180519	20180519
	UniProtAcc	P51398	Q5VT52
	Ensembl transtripts involved in fusion gene	ENST00000471642, ENST00000368336, ENST00000343043, ENST00000496863, ENST00000535183, ENST00000421487, ENST00000465375,	ENST00000492220, ENST00000401000, ENST00000539519, ENST00000369067, ENST00000369068,
Fusion gene scores	* DoF score	5 X 5 X 4=100	8 X 5 X 7=280
	# samples	5	8
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DAP3 [Title/Abstract] AND RPRD2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-DX-AB2S-01A	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
TCGA	LD	SARC	TCGA-DX-AB2S-01A	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000471642	ENST00000492220	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000471642	ENST00000401000	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000471642	ENST00000539519	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000471642	ENST00000369067	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000471642	ENST00000369068	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000368336	ENST00000492220	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000368336	ENST00000401000	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000368336	ENST00000539519	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000368336	ENST00000369067	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000368336	ENST00000369068	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000343043	ENST00000492220	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000343043	ENST00000401000	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000343043	ENST00000539519	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000343043	ENST00000369067	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000343043	ENST00000369068	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
3UTR-3UTR	ENST00000496863	ENST00000492220	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
3UTR-3UTR	ENST00000496863	ENST00000401000	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
3UTR-3UTR	ENST00000496863	ENST00000539519	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
3UTR-intron	ENST00000496863	ENST00000369067	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
3UTR-intron	ENST00000496863	ENST00000369068	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000535183	ENST00000492220	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000535183	ENST00000401000	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000535183	ENST00000539519	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000535183	ENST00000369067	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000535183	ENST00000369068	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
intron-3UTR	ENST00000421487	ENST00000492220	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
intron-3UTR	ENST00000421487	ENST00000401000	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
intron-3UTR	ENST00000421487	ENST00000539519	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
intron-intron	ENST00000421487	ENST00000369067	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
intron-intron	ENST00000421487	ENST00000369068	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000465375	ENST00000492220	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000465375	ENST00000401000	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000465375	ENST00000539519	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000465375	ENST00000369067	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000465375	ENST00000369068	DAP3	chr1	155691409	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000471642	ENST00000492220	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000471642	ENST00000401000	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000471642	ENST00000539519	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000471642	ENST00000369067	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000471642	ENST00000369068	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000368336	ENST00000492220	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000368336	ENST00000401000	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000368336	ENST00000539519	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000368336	ENST00000369067	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000368336	ENST00000369068	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000343043	ENST00000492220	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000343043	ENST00000401000	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000343043	ENST00000539519	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000343043	ENST00000369067	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000343043	ENST00000369068	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
3UTR-3UTR	ENST00000496863	ENST00000492220	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
3UTR-3UTR	ENST00000496863	ENST00000401000	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
3UTR-3UTR	ENST00000496863	ENST00000539519	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
3UTR-intron	ENST00000496863	ENST00000369067	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
3UTR-intron	ENST00000496863	ENST00000369068	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000535183	ENST00000492220	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000535183	ENST00000401000	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000535183	ENST00000539519	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000535183	ENST00000369067	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000535183	ENST00000369068	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000421487	ENST00000492220	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000421487	ENST00000401000	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-3UTR	ENST00000421487	ENST00000539519	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000421487	ENST00000369067	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
5CDS-intron	ENST00000421487	ENST00000369068	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
intron-3UTR	ENST00000465375	ENST00000492220	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
intron-3UTR	ENST00000465375	ENST00000401000	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
intron-3UTR	ENST00000465375	ENST00000539519	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
intron-intron	ENST00000465375	ENST00000369067	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+
intron-intron	ENST00000465375	ENST00000369068	DAP3	chr1	155695202	+	RPRD2	chr1	150437003	+

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FusionProtFeatures for DAP3_RPRD2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DAP3 P51398	RPRD2 Q5VT52
Involved in mediating interferon-gamma-induced celldeath.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for DAP3_RPRD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAP3_RPRD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
DAP3	CNBP, NR3C1, PPARA, HSP90AA1, HIF1A, AHR, ESR1, ESR2, PGR, THRA, AR, DAP3, TNFRSF10A, TNFRSF25, FADD, UBC, ICT1, DYRK2, MRPS27, STOML2, COX5A, YME1L1, C1QBP, SOX2, TARDBP, PARK2, GRSF1, CEP250, HAUS2, VCP, FBXW11, BTRC, TRA2A, RPL6, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS35, MRPS10, WDFY2, MTIF2, PNMA6A, MRPS5, NTRK1, PTCD3, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS28, MRPS9, LYST, COL4A5, CSNK1D, MBNL1, PYCR1, HNRNPU, MAGEA1, AP3D1, POC1A, MRPS11, ZNF746, DUSP11, MRPS34, MRPS15, AURKAIP1, RRS1, ZBTB48, E4F1, BHLHA15, FGF8, ZNF331, U2AF2, ZNF324B, ZNF133, ZNF408, SNRNP70, CCDC59, GLTSCR2, RBM3, NCL, DLD	RPRD2	PPP1CA, ELAVL1, DGCR8, PPP1CC, CSNK2A1, MPG, UPF1, WWOX, RPA3, RPA2, RPA1, RPRD1B, POLR2G, NTRK1, B9D2, XPO1, DYNC1H1, NCBP1, SUPT5H, CTR9, LEO1, TSSC1, STRAP, HIF1AN, HSPA8, LMO2, MTNR1B

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for DAP3_RPRD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for DAP3_RPRD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DAP3	C1458155	Mammary Neoplasms	1	CTD_human

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Fusion gene ID: 9282

FusionGeneSummary for DAP3_RPRD2

FusionProtFeatures for DAP3_RPRD2

FusionGeneSequence for DAP3_RPRD2

FusionGenePPI for DAP3_RPRD2

RelatedDrugs for DAP3_RPRD2

RelatedDiseases for DAP3_RPRD2