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Fusion gene ID: 9281 |
FusionGeneSummary for DAP3_OBSCN |
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Fusion gene information | Fusion gene name: DAP3_OBSCN | Fusion gene ID: 9281 | Hgene | Tgene | Gene symbol | DAP3 | OBSCN | Gene ID | 58512 | 84033 |
Gene name | DLG associated protein 3 | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | |
Synonyms | DAP3|SAPAP3 | ARHGEF30|UNC89 | |
Cytomap | 1p34.3 | 1q42.13 | |
Type of gene | protein-coding | protein-coding | |
Description | disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3 | obscurinobscurin, myosin light chain kinaseobscurin-MLCK | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P51398 | Q5VST9 | |
Ensembl transtripts involved in fusion gene | ENST00000471642, ENST00000368336, ENST00000343043, ENST00000496863, ENST00000535183, ENST00000421487, ENST00000465375, | ENST00000284548, ENST00000570156, ENST00000366709, ENST00000422127, ENST00000366707, ENST00000359599, ENST00000602685, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: DAP3 [Title/Abstract] AND OBSCN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-S3-A6ZG-01A | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000471642 | ENST00000284548 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000471642 | ENST00000570156 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000471642 | ENST00000366709 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000471642 | ENST00000422127 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000471642 | ENST00000366707 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000471642 | ENST00000359599 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000471642 | ENST00000602685 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000368336 | ENST00000284548 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000368336 | ENST00000570156 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000368336 | ENST00000366709 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000368336 | ENST00000422127 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000368336 | ENST00000366707 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000368336 | ENST00000359599 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000368336 | ENST00000602685 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000343043 | ENST00000284548 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000343043 | ENST00000570156 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000343043 | ENST00000366709 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000343043 | ENST00000422127 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000343043 | ENST00000366707 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000343043 | ENST00000359599 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000343043 | ENST00000602685 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
3UTR-3CDS | ENST00000496863 | ENST00000284548 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
3UTR-3CDS | ENST00000496863 | ENST00000570156 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
3UTR-3CDS | ENST00000496863 | ENST00000366709 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
3UTR-3CDS | ENST00000496863 | ENST00000422127 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
3UTR-3CDS | ENST00000496863 | ENST00000366707 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
3UTR-intron | ENST00000496863 | ENST00000359599 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
3UTR-intron | ENST00000496863 | ENST00000602685 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000535183 | ENST00000284548 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000535183 | ENST00000570156 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000535183 | ENST00000366709 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000535183 | ENST00000422127 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000535183 | ENST00000366707 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000535183 | ENST00000359599 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000535183 | ENST00000602685 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000421487 | ENST00000284548 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000421487 | ENST00000570156 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000421487 | ENST00000366709 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000421487 | ENST00000422127 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000421487 | ENST00000366707 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000421487 | ENST00000359599 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000421487 | ENST00000602685 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000465375 | ENST00000284548 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000465375 | ENST00000570156 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000465375 | ENST00000366709 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000465375 | ENST00000422127 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-3CDS | ENST00000465375 | ENST00000366707 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000465375 | ENST00000359599 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
5UTR-intron | ENST00000465375 | ENST00000602685 | DAP3 | chr1 | 155658965 | + | OBSCN | chr1 | 228520561 | + |
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FusionProtFeatures for DAP3_OBSCN |
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Hgene | Tgene |
DAP3 | OBSCN |
Involved in mediating interferon-gamma-induced celldeath. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DAP3_OBSCN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DAP3_OBSCN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DAP3 | CNBP, NR3C1, PPARA, HSP90AA1, HIF1A, AHR, ESR1, ESR2, PGR, THRA, AR, DAP3, TNFRSF10A, TNFRSF25, FADD, UBC, ICT1, DYRK2, MRPS27, STOML2, COX5A, YME1L1, C1QBP, SOX2, TARDBP, PARK2, GRSF1, CEP250, HAUS2, VCP, FBXW11, BTRC, TRA2A, RPL6, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS35, MRPS10, WDFY2, MTIF2, PNMA6A, MRPS5, NTRK1, PTCD3, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS28, MRPS9, LYST, COL4A5, CSNK1D, MBNL1, PYCR1, HNRNPU, MAGEA1, AP3D1, POC1A, MRPS11, ZNF746, DUSP11, MRPS34, MRPS15, AURKAIP1, RRS1, ZBTB48, E4F1, BHLHA15, FGF8, ZNF331, U2AF2, ZNF324B, ZNF133, ZNF408, SNRNP70, CCDC59, GLTSCR2, RBM3, NCL, DLD | OBSCN | ANK1, TTN, KCTD6, MPG, MOV10, NXF1, BRCA1, HNRNPD, HSF2, PCNA, RPA1, KIAA1107, C10orf12, VPS18, CDCA5, NPPA, LYPD4, UBE2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DAP3_OBSCN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DAP3_OBSCN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DAP3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |