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Fusion gene ID: 9280 |
FusionGeneSummary for DAP3_ATP8B2 |
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Fusion gene information | Fusion gene name: DAP3_ATP8B2 | Fusion gene ID: 9280 | Hgene | Tgene | Gene symbol | DAP3 | ATP8B2 | Gene ID | 58512 | 57198 |
Gene name | DLG associated protein 3 | ATPase phospholipid transporting 8B2 | |
Synonyms | DAP3|SAPAP3 | ATPID | |
Cytomap | 1p34.3 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3 | phospholipid-transporting ATPase ID36/8-9 fusion protein with epitope for anti-lectin antibodyATPase, aminophospholipid transporter, class I, type 8B, member 2ATPase, class I, type 8B, member 2P4-ATPase flippase complex alpha subunit ATP8B2probable p | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P51398 | P98198 | |
Ensembl transtripts involved in fusion gene | ENST00000471642, ENST00000368336, ENST00000343043, ENST00000496863, ENST00000535183, ENST00000421487, ENST00000465375, | ENST00000368487, ENST00000368489, ENST00000426445, ENST00000341822, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DAP3 [Title/Abstract] AND ATP8B2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-G9-6363-01A | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000471642 | ENST00000368487 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000471642 | ENST00000368489 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000471642 | ENST00000426445 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000471642 | ENST00000341822 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000368336 | ENST00000368487 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000368336 | ENST00000368489 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000368336 | ENST00000426445 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000368336 | ENST00000341822 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000343043 | ENST00000368487 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000343043 | ENST00000368489 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000343043 | ENST00000426445 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000343043 | ENST00000341822 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
3UTR-intron | ENST00000496863 | ENST00000368487 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
3UTR-intron | ENST00000496863 | ENST00000368489 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
3UTR-intron | ENST00000496863 | ENST00000426445 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
3UTR-intron | ENST00000496863 | ENST00000341822 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000535183 | ENST00000368487 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000535183 | ENST00000368489 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000535183 | ENST00000426445 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000535183 | ENST00000341822 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000421487 | ENST00000368487 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000421487 | ENST00000368489 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000421487 | ENST00000426445 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000421487 | ENST00000341822 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000465375 | ENST00000368487 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000465375 | ENST00000368489 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000465375 | ENST00000426445 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
5UTR-intron | ENST00000465375 | ENST00000341822 | DAP3 | chr1 | 155658965 | + | ATP8B2 | chr1 | 154317447 | + |
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FusionProtFeatures for DAP3_ATP8B2 |
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Hgene | Tgene |
DAP3 | ATP8B2 |
Involved in mediating interferon-gamma-induced celldeath. | Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). {ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DAP3_ATP8B2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DAP3_ATP8B2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DAP3 | CNBP, NR3C1, PPARA, HSP90AA1, HIF1A, AHR, ESR1, ESR2, PGR, THRA, AR, DAP3, TNFRSF10A, TNFRSF25, FADD, UBC, ICT1, DYRK2, MRPS27, STOML2, COX5A, YME1L1, C1QBP, SOX2, TARDBP, PARK2, GRSF1, CEP250, HAUS2, VCP, FBXW11, BTRC, TRA2A, RPL6, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS35, MRPS10, WDFY2, MTIF2, PNMA6A, MRPS5, NTRK1, PTCD3, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS28, MRPS9, LYST, COL4A5, CSNK1D, MBNL1, PYCR1, HNRNPU, MAGEA1, AP3D1, POC1A, MRPS11, ZNF746, DUSP11, MRPS34, MRPS15, AURKAIP1, RRS1, ZBTB48, E4F1, BHLHA15, FGF8, ZNF331, U2AF2, ZNF324B, ZNF133, ZNF408, SNRNP70, CCDC59, GLTSCR2, RBM3, NCL, DLD | ATP8B2 | SPINT2, KITLG, MCOLN3, LPAR6, YIPF3, CLEC2D, CHCHD10, CD79B, TMED2, B4GAT1, SLC6A15, SLC39A4, HTR3A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DAP3_ATP8B2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DAP3_ATP8B2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DAP3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |