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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9280

FusionGeneSummary for DAP3_ATP8B2

check button Fusion gene summary
Fusion gene informationFusion gene name: DAP3_ATP8B2
Fusion gene ID: 9280
HgeneTgene
Gene symbol

DAP3

ATP8B2

Gene ID

58512

57198

Gene nameDLG associated protein 3ATPase phospholipid transporting 8B2
SynonymsDAP3|SAPAP3ATPID
Cytomap

1p34.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptiondisks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3phospholipid-transporting ATPase ID36/8-9 fusion protein with epitope for anti-lectin antibodyATPase, aminophospholipid transporter, class I, type 8B, member 2ATPase, class I, type 8B, member 2P4-ATPase flippase complex alpha subunit ATP8B2probable p
Modification date2018051920180523
UniProtAcc

P51398

P98198

Ensembl transtripts involved in fusion geneENST00000471642, ENST00000368336, 
ENST00000343043, ENST00000496863, 
ENST00000535183, ENST00000421487, 
ENST00000465375, 
ENST00000368487, 
ENST00000368489, ENST00000426445, 
ENST00000341822, 
Fusion gene scores* DoF score5 X 5 X 4=1001 X 1 X 1=1
# samples 51
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DAP3 [Title/Abstract] AND ATP8B2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-G9-6363-01ADAP3chr1

155658965

+ATP8B2chr1

154317447

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000471642ENST00000368487DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000471642ENST00000368489DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000471642ENST00000426445DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000471642ENST00000341822DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000368336ENST00000368487DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000368336ENST00000368489DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000368336ENST00000426445DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000368336ENST00000341822DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000343043ENST00000368487DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000343043ENST00000368489DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000343043ENST00000426445DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000343043ENST00000341822DAP3chr1

155658965

+ATP8B2chr1

154317447

+
3UTR-intronENST00000496863ENST00000368487DAP3chr1

155658965

+ATP8B2chr1

154317447

+
3UTR-intronENST00000496863ENST00000368489DAP3chr1

155658965

+ATP8B2chr1

154317447

+
3UTR-intronENST00000496863ENST00000426445DAP3chr1

155658965

+ATP8B2chr1

154317447

+
3UTR-intronENST00000496863ENST00000341822DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000535183ENST00000368487DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000535183ENST00000368489DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000535183ENST00000426445DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000535183ENST00000341822DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000421487ENST00000368487DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000421487ENST00000368489DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000421487ENST00000426445DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000421487ENST00000341822DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000465375ENST00000368487DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000465375ENST00000368489DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000465375ENST00000426445DAP3chr1

155658965

+ATP8B2chr1

154317447

+
5UTR-intronENST00000465375ENST00000341822DAP3chr1

155658965

+ATP8B2chr1

154317447

+

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FusionProtFeatures for DAP3_ATP8B2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAP3

P51398

ATP8B2

P98198

Involved in mediating interferon-gamma-induced celldeath. Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAP3_ATP8B2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAP3_ATP8B2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DAP3CNBP, NR3C1, PPARA, HSP90AA1, HIF1A, AHR, ESR1, ESR2, PGR, THRA, AR, DAP3, TNFRSF10A, TNFRSF25, FADD, UBC, ICT1, DYRK2, MRPS27, STOML2, COX5A, YME1L1, C1QBP, SOX2, TARDBP, PARK2, GRSF1, CEP250, HAUS2, VCP, FBXW11, BTRC, TRA2A, RPL6, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS35, MRPS10, WDFY2, MTIF2, PNMA6A, MRPS5, NTRK1, PTCD3, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS28, MRPS9, LYST, COL4A5, CSNK1D, MBNL1, PYCR1, HNRNPU, MAGEA1, AP3D1, POC1A, MRPS11, ZNF746, DUSP11, MRPS34, MRPS15, AURKAIP1, RRS1, ZBTB48, E4F1, BHLHA15, FGF8, ZNF331, U2AF2, ZNF324B, ZNF133, ZNF408, SNRNP70, CCDC59, GLTSCR2, RBM3, NCL, DLDATP8B2SPINT2, KITLG, MCOLN3, LPAR6, YIPF3, CLEC2D, CHCHD10, CD79B, TMED2, B4GAT1, SLC6A15, SLC39A4, HTR3A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAP3_ATP8B2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DAP3_ATP8B2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDAP3C1458155Mammary Neoplasms1CTD_human