![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 9279 |
FusionGeneSummary for DAP3_ATF3 |
![]() |
Fusion gene information | Fusion gene name: DAP3_ATF3 | Fusion gene ID: 9279 | Hgene | Tgene | Gene symbol | DAP3 | ATF3 | Gene ID | 58512 | 467 |
Gene name | DLG associated protein 3 | activating transcription factor 3 | |
Synonyms | DAP3|SAPAP3 | - | |
Cytomap | 1p34.3 | 1q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3 | cyclic AMP-dependent transcription factor ATF-3cAMP-dependent transcription factor ATF-3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P51398 | P18847 | |
Ensembl transtripts involved in fusion gene | ENST00000471642, ENST00000368336, ENST00000343043, ENST00000496863, ENST00000535183, ENST00000421487, ENST00000465375, | ENST00000366987, ENST00000341491, ENST00000366985, ENST00000492118, ENST00000336937, ENST00000366983, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 4 X 2=32 |
# samples | 5 | 4 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DAP3 [Title/Abstract] AND ATF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ATF3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8622660 |
Tgene | ATF3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16300731 |
Tgene | ATF3 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 24939851 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A08L-01A | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000471642 | ENST00000366987 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-5UTR | ENST00000471642 | ENST00000341491 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-5UTR | ENST00000471642 | ENST00000366985 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-intron | ENST00000471642 | ENST00000492118 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-intron | ENST00000471642 | ENST00000336937 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-intron | ENST00000471642 | ENST00000366983 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000368336 | ENST00000366987 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000368336 | ENST00000341491 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000368336 | ENST00000366985 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000368336 | ENST00000492118 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000368336 | ENST00000336937 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000368336 | ENST00000366983 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000343043 | ENST00000366987 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000343043 | ENST00000341491 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000343043 | ENST00000366985 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000343043 | ENST00000492118 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000343043 | ENST00000336937 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000343043 | ENST00000366983 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
3UTR-5UTR | ENST00000496863 | ENST00000366987 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
3UTR-5UTR | ENST00000496863 | ENST00000341491 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
3UTR-5UTR | ENST00000496863 | ENST00000366985 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
3UTR-intron | ENST00000496863 | ENST00000492118 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
3UTR-intron | ENST00000496863 | ENST00000336937 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
3UTR-intron | ENST00000496863 | ENST00000366983 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-5UTR | ENST00000535183 | ENST00000366987 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-5UTR | ENST00000535183 | ENST00000341491 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-5UTR | ENST00000535183 | ENST00000366985 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-intron | ENST00000535183 | ENST00000492118 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-intron | ENST00000535183 | ENST00000336937 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
intron-intron | ENST00000535183 | ENST00000366983 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000421487 | ENST00000366987 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000421487 | ENST00000341491 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000421487 | ENST00000366985 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000421487 | ENST00000492118 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000421487 | ENST00000336937 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000421487 | ENST00000366983 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000465375 | ENST00000366987 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000465375 | ENST00000341491 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-5UTR | ENST00000465375 | ENST00000366985 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000465375 | ENST00000492118 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000465375 | ENST00000336937 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
5CDS-intron | ENST00000465375 | ENST00000366983 | DAP3 | chr1 | 155686919 | + | ATF3 | chr1 | 212788360 | + |
Top |
FusionProtFeatures for DAP3_ATF3 |
![]() |
Hgene | Tgene |
DAP3 | ATF3 |
Involved in mediating interferon-gamma-induced celldeath. | This protein binds the cAMP response element (CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in manyviral and cellular promoters. Represses transcription frompromoters with ATF sites. It may repress transcription bystabilizing the binding of inhibitory cofactors at the promoter.Isoform 2 activates transcription presumably by sequesteringinhibitory cofactors away from the promoters. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for DAP3_ATF3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for DAP3_ATF3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DAP3 | CNBP, NR3C1, PPARA, HSP90AA1, HIF1A, AHR, ESR1, ESR2, PGR, THRA, AR, DAP3, TNFRSF10A, TNFRSF25, FADD, UBC, ICT1, DYRK2, MRPS27, STOML2, COX5A, YME1L1, C1QBP, SOX2, TARDBP, PARK2, GRSF1, CEP250, HAUS2, VCP, FBXW11, BTRC, TRA2A, RPL6, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS35, MRPS10, WDFY2, MTIF2, PNMA6A, MRPS5, NTRK1, PTCD3, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS28, MRPS9, LYST, COL4A5, CSNK1D, MBNL1, PYCR1, HNRNPU, MAGEA1, AP3D1, POC1A, MRPS11, ZNF746, DUSP11, MRPS34, MRPS15, AURKAIP1, RRS1, ZBTB48, E4F1, BHLHA15, FGF8, ZNF331, U2AF2, ZNF324B, ZNF133, ZNF408, SNRNP70, CCDC59, GLTSCR2, RBM3, NCL, DLD | ATF3 | JUN, SMAD3, IGSF21, LRIF1, FGFR3, TP53, JUND, DDIT3, ATF4, MDM2, POLR3D, ATF2, SS18L1, SMARCA4, RELA, CEBPE, HDAC1, CEBPB, GSK3B, SMAD2, CREBBP, STAT1, PDX1, ACTB, HDAC6, HDAC10, HDAC4, HDAC5, HDAC3, ATF3, FHL2, ID3, ZNF212, SRA1, HSP90AA1, MAFG, MAFF, BATF3, BATF, FOSL1, FOS, JUNB, CEBPA, CEBPG, DBP, CREB3, SUV39H1, UBE2I, SH2D1A, APPL2, CRK, DOK5, STAT3, EWSR1, MEF2A, NFATC1, TEAD2, KAT5, DNMT3L, TRIM25, TP63 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DAP3_ATF3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DAP3_ATF3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DAP3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | ATF3 | C0027765 | nervous system disorder | 2 | CTD_human |
Tgene | ATF3 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | ATF3 | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | ATF3 | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | ATF3 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Tgene | ATF3 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Tgene | ATF3 | C0021400 | Influenza | 1 | CTD_human |
Tgene | ATF3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ATF3 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | ATF3 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Tgene | ATF3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ATF3 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
Tgene | ATF3 | C0848558 | Hypospadias | 1 | CTD_human |
Tgene | ATF3 | C0878544 | Cardiomyopathies | 1 | CTD_human |
Tgene | ATF3 | C0919267 | ovarian neoplasm | 1 | CTD_human |