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Fusion gene ID: 9277 |
FusionGeneSummary for DANCR_TIMMDC1 |
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Fusion gene information | Fusion gene name: DANCR_TIMMDC1 | Fusion gene ID: 9277 | Hgene | Tgene | Gene symbol | DANCR | TIMMDC1 | Gene ID | 57291 | 51300 |
Gene name | differentiation antagonizing non-protein coding RNA | translocase of inner mitochondrial membrane domain containing 1 | |
Synonyms | AGU2|ANCR|KIAA0114|SNHG13|lncRNA-ANCR | C3orf1 | |
Cytomap | 4q12 | 3q13.33 | |
Type of gene | ncRNA | protein-coding | |
Description | adipogenesis up-regulated transcript 2anti-differentiation ncRNAanti-differentiation noncoding RNAsmall nucleolar RNA host gene 13 (non-protein coding) | complex I assembly factor TIMMDC1, mitochondrialM5-14 proteinTIMM domain containing-protein 1translocase of inner mitochondrial membrane domain-containing protein 1transmembrane protein C3orf1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9NPL8 | ||
Ensembl transtripts involved in fusion gene | ENST00000411630, | ENST00000494664, ENST00000493694, | |
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 3 X 3 X 3=27 |
# samples | 5 | 3 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DANCR [Title/Abstract] AND TIMMDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | GBM | TCGA-27-1830-01A | DANCR | chr4 | 53579126 | + | TIMMDC1 | chr3 | 119219542 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000411630 | ENST00000494664 | DANCR | chr4 | 53579126 | + | TIMMDC1 | chr3 | 119219542 | + |
3UTR-intron | ENST00000411630 | ENST00000493694 | DANCR | chr4 | 53579126 | + | TIMMDC1 | chr3 | 119219542 | + |
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FusionProtFeatures for DANCR_TIMMDC1 |
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Hgene | Tgene |
DANCR | TIMMDC1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Chaperone protein involved in the assembly of themitochondrial NADH:ubiquinone oxidoreductase complex (complex I).Participates in constructing the membrane arm of complex I.{ECO:0000269|PubMed:24191001}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DANCR_TIMMDC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DANCR_TIMMDC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DANCR | TRIM25, EZH2, CDK1 | TIMMDC1 | HGS, APP, ABCD3, FATE1, RNF2, ARL5B, NDUFAF1, ECSIT, ACAD9, NDUFC2, TMEM126B, NDUFS5, NDUFA13, NDUFAF3, ND1, NDUFAF4, SAMM50, APOO, COX5B, MTCH1, NDUFA8, ND4, NDUFA3, NDUFB6, NDUFB8, UQCR10, NDUFS2, COX6B1, NDUFB10, NDUFB9, YME1L1, NDUFS7, COX7A2L, HCCS, NDUFB4, TIMM8A, NDUFS8, NDUFV1, AFG3L2, NDUFA9, ATP5I, ND2, NDUFA12, NDUFV3, OCIAD1, UNC80, C2orf47, NDUFB5, LAMB3, LRPPRC, FAF2, NDUFA4, NDUFS3, COQ9, DUSP19, DUSP21, DUSP6 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DANCR_TIMMDC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DANCR_TIMMDC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |