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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9276

FusionGeneSummary for DANCR_TBC1D10A

check button Fusion gene summary
Fusion gene informationFusion gene name: DANCR_TBC1D10A
Fusion gene ID: 9276
HgeneTgene
Gene symbol

DANCR

TBC1D10A

Gene ID

57291

83874

Gene namedifferentiation antagonizing non-protein coding RNATBC1 domain family member 10A
SynonymsAGU2|ANCR|KIAA0114|SNHG13|lncRNA-ANCREPI64|TBC1D10|dJ130H16.1|dJ130H16.2
Cytomap

4q12

22q12.2

Type of genencRNAprotein-coding
Descriptionadipogenesis up-regulated transcript 2anti-differentiation ncRNAanti-differentiation noncoding RNAsmall nucleolar RNA host gene 13 (non-protein coding)TBC1 domain family member 10AEBP50-PDX interactor of 64 kDaEBP50-PDZ interactor of 64 kDrab27A-GAP-alpha
Modification date2018051920180523
UniProtAcc

Q9BXI6

Ensembl transtripts involved in fusion geneENST00000411630, ENST00000215790, 
ENST00000403477, ENST00000403362, 
ENST00000490449, 
Fusion gene scores* DoF score5 X 4 X 3=604 X 5 X 2=40
# samples 55
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DANCR [Title/Abstract] AND TBC1D10A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTBC1D10A

GO:0045862

positive regulation of proteolysis

18387192

TgeneTBC1D10A

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI089294DANCRchr4

53579127

+TBC1D10Achr22

30700622

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000411630ENST00000215790DANCRchr4

53579127

+TBC1D10Achr22

30700622

-
3UTR-3CDSENST00000411630ENST00000403477DANCRchr4

53579127

+TBC1D10Achr22

30700622

-
3UTR-5UTRENST00000411630ENST00000403362DANCRchr4

53579127

+TBC1D10Achr22

30700622

-
3UTR-5UTRENST00000411630ENST00000490449DANCRchr4

53579127

+TBC1D10Achr22

30700622

-

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FusionProtFeatures for DANCR_TBC1D10A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DANCR

TBC1D10A

Q9BXI6

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Acts as GTPase-activating protein for RAB27A, but notfor RAB2A, RAB3A, nor RAB4A. {ECO:0000269|PubMed:16923811}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DANCR_TBC1D10A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DANCR_TBC1D10A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DANCRTRIM25, EZH2, CDK1TBC1D10ASLC9A3R1, MAP1LC3A, GABARAPL1, TERF1, TERF2IP, ACD, TEX13A, FGL1, BACH1, FERMT3, CDH1, CNOT11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DANCR_TBC1D10A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DANCR_TBC1D10A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource