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Fusion gene ID: 9275 |
FusionGeneSummary for DANCR_RNF31 |
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Fusion gene information | Fusion gene name: DANCR_RNF31 | Fusion gene ID: 9275 | Hgene | Tgene | Gene symbol | DANCR | RNF31 | Gene ID | 57291 | 55072 |
Gene name | differentiation antagonizing non-protein coding RNA | ring finger protein 31 | |
Synonyms | AGU2|ANCR|KIAA0114|SNHG13|lncRNA-ANCR | HOIP|Paul|ZIBRA | |
Cytomap | 4q12 | 14q12 | |
Type of gene | ncRNA | protein-coding | |
Description | adipogenesis up-regulated transcript 2anti-differentiation ncRNAanti-differentiation noncoding RNAsmall nucleolar RNA host gene 13 (non-protein coding) | E3 ubiquitin-protein ligase RNF31HOIL-1-interacting proteinRING-type E3 ubiquitin transferase RNF31zinc in-between-RING-finger ubiquitin-associated domain protein | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q96EP0 | ||
Ensembl transtripts involved in fusion gene | ENST00000411630, | ENST00000557878, ENST00000559275, ENST00000324103, ENST00000382687, | |
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 5 X 5 X 4=100 |
# samples | 5 | 6 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DANCR [Title/Abstract] AND RNF31 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RNF31 | GO:0000209 | protein polyubiquitination | 12629548|17006537 |
Tgene | RNF31 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 19136968|21455173 |
Tgene | RNF31 | GO:0050852 | T cell receptor signaling pathway | 20005846 |
Tgene | RNF31 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 19136968 |
Tgene | RNF31 | GO:0097039 | protein linear polyubiquitination | 21455173|21455180|21455181|23453807 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN344563 | DANCR | chr4 | 53579128 | + | RNF31 | chr14 | 24624160 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000411630 | ENST00000557878 | DANCR | chr4 | 53579128 | + | RNF31 | chr14 | 24624160 | + |
3UTR-intron | ENST00000411630 | ENST00000559275 | DANCR | chr4 | 53579128 | + | RNF31 | chr14 | 24624160 | + |
3UTR-intron | ENST00000411630 | ENST00000324103 | DANCR | chr4 | 53579128 | + | RNF31 | chr14 | 24624160 | + |
3UTR-intron | ENST00000411630 | ENST00000382687 | DANCR | chr4 | 53579128 | + | RNF31 | chr14 | 24624160 | + |
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FusionProtFeatures for DANCR_RNF31 |
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Hgene | Tgene |
DANCR | RNF31 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | E3 ubiquitin-protein ligase component of the LUBACcomplex which conjugates linear ('Met-1'-linked) polyubiquitinchains to substrates and plays a key role in NF-kappa-B activationand regulation of inflammation (PubMed:17006537, PubMed:19136968,PubMed:20005846, PubMed:21455173, PubMed:21455180,PubMed:21455181, PubMed:22863777). LUBAC conjugates linearpolyubiquitin to IKBKG and RIPK1 and is involved in activation ofthe canonical NF-kappa-B and the JNK signaling pathways(PubMed:17006537, PubMed:19136968, PubMed:20005846,PubMed:21455173, PubMed:21455180, PubMed:21455181,PubMed:22863777). Linear ubiquitination mediated by the LUBACcomplex interferes with TNF-induced cell death and therebyprevents inflammation (PubMed:21455173). LUBAC is proposed to berecruited to the TNF-R1 signaling complex (TNF-RSC) followingpolyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 andto conjugate linear polyubiquitin to IKBKG and possibly othercomponents contributing to the stability of the complex(PubMed:20005846). Together with otulin, the LUBAC complexregulates the canonical Wnt signaling during angiogenesis. Bindspolyubiquitin of different linkage types (PubMed:23708998).{ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968,ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173,ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181,ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DANCR_RNF31 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DANCR_RNF31 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DANCR_RNF31 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DANCR_RNF31 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |