|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 9253 |
FusionGeneSummary for DAD1_RAB2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DAD1_RAB2B | Fusion gene ID: 9253 | Hgene | Tgene | Gene symbol | DAD1 | RAB2B | Gene ID | 1603 | 84932 |
| Gene name | defender against cell death 1 | RAB2B, member RAS oncogene family | |
| Synonyms | OST2 | - | |
| Cytomap | 14q11.2 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1DAD-1oligosaccharyl transferase subunit DAD1oligosaccharyltransferase 2 homologoligosaccharyltransferase subunit 2 (non-catalytic) | ras-related protein Rab-2BGTP-binding protein RAB2BRAS family, member RAB2B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P61803 | Q8WUD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000250498, ENST00000489532, ENST00000538631, ENST00000543337, | ENST00000397762, ENST00000461909, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 1 X 1=2 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/2*10)=3.32192809488736 | |
| Context | PubMed: DAD1 [Title/Abstract] AND RAB2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AC-A6IW-01A | DAD1 | chr14 | 23057853 | - | RAB2B | chr14 | 21936911 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000250498 | ENST00000397762 | DAD1 | chr14 | 23057853 | - | RAB2B | chr14 | 21936911 | - |
| 5CDS-5UTR | ENST00000250498 | ENST00000461909 | DAD1 | chr14 | 23057853 | - | RAB2B | chr14 | 21936911 | - |
| intron-3CDS | ENST00000489532 | ENST00000397762 | DAD1 | chr14 | 23057853 | - | RAB2B | chr14 | 21936911 | - |
| intron-5UTR | ENST00000489532 | ENST00000461909 | DAD1 | chr14 | 23057853 | - | RAB2B | chr14 | 21936911 | - |
| In-frame | ENST00000538631 | ENST00000397762 | DAD1 | chr14 | 23057853 | - | RAB2B | chr14 | 21936911 | - |
| 5CDS-5UTR | ENST00000538631 | ENST00000461909 | DAD1 | chr14 | 23057853 | - | RAB2B | chr14 | 21936911 | - |
| intron-3CDS | ENST00000543337 | ENST00000397762 | DAD1 | chr14 | 23057853 | - | RAB2B | chr14 | 21936911 | - |
| intron-5UTR | ENST00000543337 | ENST00000461909 | DAD1 | chr14 | 23057853 | - | RAB2B | chr14 | 21936911 | - |
Top |
FusionProtFeatures for DAD1_RAB2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DAD1 | RAB2B |
| Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. Required for the assembly of bothSST3A- and SS3B-containing OST complexes. Required for efficientN-glycosylation. Loss of the DAD1 protein triggers apoptosis.{ECO:0000269|PubMed:22467853, ECO:0000305}. | Required for protein transport from the endoplasmicreticulum to the Golgi complex. {ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DAD1 | chr14:23057853 | chr14:21936911 | ENST00000250498 | - | 1 | 3 | 2_30 | 70 | 84 | Topological domain | Cytoplasmic |
| Hgene | DAD1 | chr14:23057853 | chr14:21936911 | ENST00000250498 | - | 1 | 3 | 52_52 | 70 | 84 | Topological domain | Lumenal |
| Hgene | DAD1 | chr14:23057853 | chr14:21936911 | ENST00000250498 | - | 1 | 3 | 31_51 | 70 | 84 | Transmembrane | Helical |
| Hgene | DAD1 | chr14:23057853 | chr14:21936911 | ENST00000250498 | - | 1 | 3 | 53_73 | 70 | 84 | Transmembrane | Helical |
| Tgene | >RAB2B | chr14:23057853 | chr14:21936911 | ENST00000397762 | - | 2 | 8 | 119_122 | 62 | 217 | Nucleotide binding | GTP |
| Tgene | >RAB2B | chr14:23057853 | chr14:21936911 | ENST00000397762 | - | 2 | 8 | 149_151 | 62 | 217 | Nucleotide binding | GTP |
| Tgene | >RAB2B | chr14:23057853 | chr14:21936911 | ENST00000397762 | - | 2 | 8 | 61_65 | 62 | 217 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DAD1 | chr14:23057853 | chr14:21936911 | ENST00000250498 | - | 1 | 3 | 74_92 | 70 | 84 | Topological domain | Cytoplasmic |
| Hgene | >DAD1 | chr14:23057853 | chr14:21936911 | ENST00000250498 | - | 1 | 3 | 93_113 | 70 | 84 | Transmembrane | Helical |
| Tgene | RAB2B | chr14:23057853 | chr14:21936911 | ENST00000397762 | - | 2 | 8 | 35_43 | 62 | 217 | Motif | Effector region |
| Tgene | RAB2B | chr14:23057853 | chr14:21936911 | ENST00000397762 | - | 2 | 8 | 13_21 | 62 | 217 | Nucleotide binding | GTP |
Top |
FusionGeneSequence for DAD1_RAB2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DAD1_ENST00000250498_chr14_23057853_-_RAB2B_ENST00000397762_chr14_21936911_-_225aa MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAGWARILPFYHPFLLQGSSWS TAGVRHYKAXNLQPPDLMVRGCPAALXFQHGYHAHWEXEXPRVPQGCEERRRRGLCXGAWTYIHGNFSQNSLQCXRGLHXHSQRNIXEDP >In-frame_DAD1_ENST00000538631_chr14_23057853_-_RAB2B_ENST00000397762_chr14_21936911_-_225aa MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAGWARILPFYHPFLLQGSSWS TAGVRHYKAXNLQPPDLMVRGCPAALXFQHGYHAHWEXEXPRVPQGCEERRRRGLCXGAWTYIHGNFSQNSLQCXRGLHXHSQRNIXEDP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DAD1_ENST00000250498_chr14_23057853_-_RAB2B_ENST00000397762_chr14_21936911_-_676nt ATGTCGGCGTCGGTAGTGTCTGTCATTTCGCGGTTCTTAGAAGAGTACTTGAGCTCCACTCCGCAGCGTCTGAAGTTGCTGGACGCGTAC CTGCTGTATATACTGCTGACCGGGGCGCTGCAGTTCGGTTACTGTCTCCTCGTGGGGACCTTCCCCTTCAACTCTTTTCTCTCGGGCTTC ATCTCTTGTGTGGGGAGTTTCATCCTAGCGGGCTGGGCAAGAATCCTTCCGTTCTATCACCCGTTCCTACTACAGGGGAGCAGCTGGAGC ACTGCTGGTGTACGACATTACAAGGCGTGAAACCTTCAACCACCTGACCTCATGGTTAGAGGATGCCCGGCAGCACTCTAGTTCCAACAT GGTTATCATGCTCATTGGGAATAAGAGTGACCTAGAGTCCCGCAGGGATGTGAAGAGAGAAGAAGGAGAGGCCTTTGCTAGGGAGCATGG ACTTATATTCATGGAAACTTCAGCCAAAACAGCCTGCAATGTTGAAGAGGCCTTCATTAACACAGCCAAAGAAATATATAGGAAGATCCA GCAGGGTTTATTTGATGTCCACAATGAGGCAAATGGCATCAAGATTGGGCCCCAACAGTCAATTTCAACATCAGTGGGACCCAGTGCCTC >In-frame_DAD1_ENST00000538631_chr14_23057853_-_RAB2B_ENST00000397762_chr14_21936911_-_676nt ATGTCGGCGTCGGTAGTGTCTGTCATTTCGCGGTTCTTAGAAGAGTACTTGAGCTCCACTCCGCAGCGTCTGAAGTTGCTGGACGCGTAC CTGCTGTATATACTGCTGACCGGGGCGCTGCAGTTCGGTTACTGTCTCCTCGTGGGGACCTTCCCCTTCAACTCTTTTCTCTCGGGCTTC ATCTCTTGTGTGGGGAGTTTCATCCTAGCGGGCTGGGCAAGAATCCTTCCGTTCTATCACCCGTTCCTACTACAGGGGAGCAGCTGGAGC ACTGCTGGTGTACGACATTACAAGGCGTGAAACCTTCAACCACCTGACCTCATGGTTAGAGGATGCCCGGCAGCACTCTAGTTCCAACAT GGTTATCATGCTCATTGGGAATAAGAGTGACCTAGAGTCCCGCAGGGATGTGAAGAGAGAAGAAGGAGAGGCCTTTGCTAGGGAGCATGG ACTTATATTCATGGAAACTTCAGCCAAAACAGCCTGCAATGTTGAAGAGGCCTTCATTAACACAGCCAAAGAAATATATAGGAAGATCCA GCAGGGTTTATTTGATGTCCACAATGAGGCAAATGGCATCAAGATTGGGCCCCAACAGTCAATTTCAACATCAGTGGGACCCAGTGCCTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DAD1_ENST00000250498_chr14_23057853_-_RAB2B_ENST00000397762_chr14_21936911_-_2964nt GGGGAGGGCGGAGTTAGGTCACGAGGGTGCGCATGCGCAAACAGCACATCCGGTGTGGTCGACGGGTCCTCCAAGAGTTTGGGGCGCGGA CTGGAGTACCTTGCGTGCAGTTATGTCGGCGTCGGTAGTGTCTGTCATTTCGCGGTTCTTAGAAGAGTACTTGAGCTCCACTCCGCAGCG TCTGAAGTTGCTGGACGCGTACCTGCTGTATATACTGCTGACCGGGGCGCTGCAGTTCGGTTACTGTCTCCTCGTGGGGACCTTCCCCTT CAACTCTTTTCTCTCGGGCTTCATCTCTTGTGTGGGGAGTTTCATCCTAGCGGGCTGGGCAAGAATCCTTCCGTTCTATCACCCGTTCCT ACTACAGGGGAGCAGCTGGAGCACTGCTGGTGTACGACATTACAAGGCGTGAAACCTTCAACCACCTGACCTCATGGTTAGAGGATGCCC GGCAGCACTCTAGTTCCAACATGGTTATCATGCTCATTGGGAATAAGAGTGACCTAGAGTCCCGCAGGGATGTGAAGAGAGAAGAAGGAG AGGCCTTTGCTAGGGAGCATGGACTTATATTCATGGAAACTTCAGCCAAAACAGCCTGCAATGTTGAAGAGGCCTTCATTAACACAGCCA AAGAAATATATAGGAAGATCCAGCAGGGTTTATTTGATGTCCACAATGAGGCAAATGGCATCAAGATTGGGCCCCAACAGTCAATTTCAA CATCAGTGGGACCCAGTGCCTCCCAGCGGAACTCTCGTGACATAGGGTCCAACTCTGGCTGCTGCTGAACATCTGGCTTGAACTTTTTTT GTCCTTCCTGGAATAGCTTCAGATCAATAGGCTTAATGAAAGAGGTCTTTCTTGCTTTGGCTGAGAGCAGCCTCTTTTTAAAGTGTGATG TTTTGCCTTTCCACCTAAAGACCAGGAGAGAATTTGGGCCCTTACTGACCTGTCCTCCTTCAGGGACATGAGCATTCCCTATAGATTAGG GTTCTTCTTATCCTCCTATACAAATTTCTTAAATTGTTAGGATCAAAGTTGATTATCACAGTAGTTAAAAAATAATTTCATGGCGGGGCG CCATGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAAGAGTTCGAGACCAGCCTGACCAACT TGGAGAAATGCCATCTCAACTGAAAATACAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAATCCCAGGTACTCGGGAGGCCAAGGCAG GAGAATCGCTTGAACCCAGGAGGTGAAGGTTACGCTAAGCCAAGATCACGCCATTGCACTGCAGCCTGGGCAACAAGAGCAAAACTCTGT CTCAAATAAATAAATAATTTTTTTTTTCTTTTTTTTTTTTTTTTTTTGGGGGGATGGAGTCTCACTCTGTCTCCAGGCTGGAGTGCAGTG GCATGATCTTGGCTCACTGCAACCTCCACTTTCCAGGTTCAAGCAGTTCTCCTGCCTCAACCTCCCGAGTAGCTGGGACTACAGGCATGT GCCACCACACCTGGCTCATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTTGATCTCTTGACCTCGTGAT CCGCCCACCTTGGCCTCCCAAAGTGCTGGATTACAGGTGTGAGCCACCGTGCCTGGCCTAAATAAATAATTTCGTAAGCATATACAATCC ACTTCCCACTAAGAATTAGGGTCAAAGACATTCTATTTGAACACTTGCAATTACCTAGATCTAGTTGGCCTTTGGTTGATAGATCCTCTG CCTCGGAATTTCATTGAGTTTTTTTCTTCCTTGCCTTTGGGTGTCTGCTTGCCACTTCCTAAGAATTCTTGTAGAAGGCAGTTTCCTCTA CTTGCCCAAGAGCACTGAGTACTTCTCTACTATCCTATTATTAGCTTCTATCTCTTAGTGTAACTTCAAAACTTTTAAGAGCAGTGAAGT TGGTCAGGGACATGTGGCCACTTATTATTACCTAAAGAAAACATTTGTTCCCTGTTCATTTTATTTTAGGGGCCAGATCTAACATTGTAG TGTCTTTCACCAGATAGACTTCTACTGTTTCATCAAACTCCCTTCTTAACTAGACCTAGACTTTCTACTCCAATCAGGCTAATCTACTTA CTGAATGTGACATATTTATTCCTAGTTCCATACCTTTGCACATGCCCTACTCTCCACTAATTATACTTAAAAGTCCAAAAATTTTTTCTT TAGTAACAGACTTAGGTACTGCTAAGCAGTTATTAACACAATATTCCTTAGTTTTCATATGTTGGTTATTCATATGTCTATTTATATGTA TATTTATTTTTATGTATGTTACTATGTAAATATGGTTTGCAGTTGTTTTTGTGTGGAATCTTGTCTTTCCGTATAAGTTGTAAGCTCCTT GAGAGCAGGATCCATGTCATTCCTTTATTTTTATAAATTATTCCCCCTATCATTCCTTTACAGTGCCTAGTGCTACTCATTATGTGTTCA TTGAATTTGACTGACATAGTTAAAAACTTAAGGTTTATTTTAGACTTTCAAGGAAACAAAAGACTTTAGAGTCCTCTCTCTGTAATTCTG CCCCACTCATTTGTTTACCCTGGGTTTTATACAGTTCTCTTCCTTCTCCCCTCCCACCTTTCCCTGGCTTTTTGCCTCCATTCCATGAGG CATACAGTAAGGCTGCCTGCTAGTAAGCAGTCACATAAGTGGGTACCTATCCAGCCATTCTCTTTTCAGAGCATATAATACTATCTTAGC CAAACTTGCCTTTGCTTCACTCATCATGCAGCCTTCTGGGTTGGTTGCTATATATATCTTTTTTCCTTGATGTCCCGTTCTCTTCCACAG >In-frame_DAD1_ENST00000538631_chr14_23057853_-_RAB2B_ENST00000397762_chr14_21936911_-_2852nt ATGTCGGCGTCGGTAGTGTCTGTCATTTCGCGGTTCTTAGAAGAGTACTTGAGCTCCACTCCGCAGCGTCTGAAGTTGCTGGACGCGTAC CTGCTGTATATACTGCTGACCGGGGCGCTGCAGTTCGGTTACTGTCTCCTCGTGGGGACCTTCCCCTTCAACTCTTTTCTCTCGGGCTTC ATCTCTTGTGTGGGGAGTTTCATCCTAGCGGGCTGGGCAAGAATCCTTCCGTTCTATCACCCGTTCCTACTACAGGGGAGCAGCTGGAGC ACTGCTGGTGTACGACATTACAAGGCGTGAAACCTTCAACCACCTGACCTCATGGTTAGAGGATGCCCGGCAGCACTCTAGTTCCAACAT GGTTATCATGCTCATTGGGAATAAGAGTGACCTAGAGTCCCGCAGGGATGTGAAGAGAGAAGAAGGAGAGGCCTTTGCTAGGGAGCATGG ACTTATATTCATGGAAACTTCAGCCAAAACAGCCTGCAATGTTGAAGAGGCCTTCATTAACACAGCCAAAGAAATATATAGGAAGATCCA GCAGGGTTTATTTGATGTCCACAATGAGGCAAATGGCATCAAGATTGGGCCCCAACAGTCAATTTCAACATCAGTGGGACCCAGTGCCTC CCAGCGGAACTCTCGTGACATAGGGTCCAACTCTGGCTGCTGCTGAACATCTGGCTTGAACTTTTTTTGTCCTTCCTGGAATAGCTTCAG ATCAATAGGCTTAATGAAAGAGGTCTTTCTTGCTTTGGCTGAGAGCAGCCTCTTTTTAAAGTGTGATGTTTTGCCTTTCCACCTAAAGAC CAGGAGAGAATTTGGGCCCTTACTGACCTGTCCTCCTTCAGGGACATGAGCATTCCCTATAGATTAGGGTTCTTCTTATCCTCCTATACA AATTTCTTAAATTGTTAGGATCAAAGTTGATTATCACAGTAGTTAAAAAATAATTTCATGGCGGGGCGCCATGGCTCATGCCTGTAATCC TAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAAGAGTTCGAGACCAGCCTGACCAACTTGGAGAAATGCCATCTCAACTG AAAATACAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAATCCCAGGTACTCGGGAGGCCAAGGCAGGAGAATCGCTTGAACCCAGGAG GTGAAGGTTACGCTAAGCCAAGATCACGCCATTGCACTGCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAATAAATAAATAATTTTT TTTTTCTTTTTTTTTTTTTTTTTTTGGGGGGATGGAGTCTCACTCTGTCTCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAA CCTCCACTTTCCAGGTTCAAGCAGTTCTCCTGCCTCAACCTCCCGAGTAGCTGGGACTACAGGCATGTGCCACCACACCTGGCTCATTTT TGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTTGATCTCTTGACCTCGTGATCCGCCCACCTTGGCCTCCCAAA GTGCTGGATTACAGGTGTGAGCCACCGTGCCTGGCCTAAATAAATAATTTCGTAAGCATATACAATCCACTTCCCACTAAGAATTAGGGT CAAAGACATTCTATTTGAACACTTGCAATTACCTAGATCTAGTTGGCCTTTGGTTGATAGATCCTCTGCCTCGGAATTTCATTGAGTTTT TTTCTTCCTTGCCTTTGGGTGTCTGCTTGCCACTTCCTAAGAATTCTTGTAGAAGGCAGTTTCCTCTACTTGCCCAAGAGCACTGAGTAC TTCTCTACTATCCTATTATTAGCTTCTATCTCTTAGTGTAACTTCAAAACTTTTAAGAGCAGTGAAGTTGGTCAGGGACATGTGGCCACT TATTATTACCTAAAGAAAACATTTGTTCCCTGTTCATTTTATTTTAGGGGCCAGATCTAACATTGTAGTGTCTTTCACCAGATAGACTTC TACTGTTTCATCAAACTCCCTTCTTAACTAGACCTAGACTTTCTACTCCAATCAGGCTAATCTACTTACTGAATGTGACATATTTATTCC TAGTTCCATACCTTTGCACATGCCCTACTCTCCACTAATTATACTTAAAAGTCCAAAAATTTTTTCTTTAGTAACAGACTTAGGTACTGC TAAGCAGTTATTAACACAATATTCCTTAGTTTTCATATGTTGGTTATTCATATGTCTATTTATATGTATATTTATTTTTATGTATGTTAC TATGTAAATATGGTTTGCAGTTGTTTTTGTGTGGAATCTTGTCTTTCCGTATAAGTTGTAAGCTCCTTGAGAGCAGGATCCATGTCATTC CTTTATTTTTATAAATTATTCCCCCTATCATTCCTTTACAGTGCCTAGTGCTACTCATTATGTGTTCATTGAATTTGACTGACATAGTTA AAAACTTAAGGTTTATTTTAGACTTTCAAGGAAACAAAAGACTTTAGAGTCCTCTCTCTGTAATTCTGCCCCACTCATTTGTTTACCCTG GGTTTTATACAGTTCTCTTCCTTCTCCCCTCCCACCTTTCCCTGGCTTTTTGCCTCCATTCCATGAGGCATACAGTAAGGCTGCCTGCTA GTAAGCAGTCACATAAGTGGGTACCTATCCAGCCATTCTCTTTTCAGAGCATATAATACTATCTTAGCCAAACTTGCCTTTGCTTCACTC ATCATGCAGCCTTCTGGGTTGGTTGCTATATATATCTTTTTTCCTTGATGTCCCGTTCTCTTCCACAGCCCTGAGGTCTTACGAATTTTT |
Top |
FusionGenePPI for DAD1_RAB2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DAD1 | MCL1, CDK2, ADRB2, EED, EFNB2, HSD11B1, F3, SGCA, LRRTM2, CLEC5A, TCTN2, TCTN3, TMEM258, GLP1R, FSHR, PDCD1, VIPR2, RPN2, SLC5A8 | RAB2B | ELAVL1, APP, ATF2, BAG3, GOLGA2, ICA1, BLZF1, ADAMTSL4, FAM114A1, FAM71C, CRK, FAM71F2, RAB2A, GDI1, RAB5B, RAB14, PRUNE, RAB4A, RAB9A, TTF2, FMN2, DSTYK, RAB21, RAB5A, LOC81691, RAB1B, UBA6, DDX19B, DMWD, RAB18, RAB1A, ATP12A, TBC1D4, BCAS3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DAD1_RAB2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DAD1_RAB2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|