	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 9230

FusionGeneSummary for DAB1_LIMCH1

Fusion gene summary

Fusion gene information	Fusion gene name: DAB1_LIMCH1
	Fusion gene ID: 9230
		Hgene	Tgene
	Gene symbol	DAB1	LIMCH1
	Gene ID	115209	22998
	Gene name	OMA1 zinc metallopeptidase	LIM and calponin homology domains 1
	Synonyms	2010001O09Rik\|DAB1\|MPRP-1\|MPRP1\|YKR087C\|ZMPOMA1\|peptidase	LIMCH1A\|LMO7B
	Cytomap	1p32.2-p32.1	4p13
	Type of gene	protein-coding	protein-coding
	Description	metalloendopeptidase OMA1, mitochondrialOMA1 homolog, zinc metallopeptidaseOMA1 zinc metallopeptidase homologmetalloprotease-related protein 1overlapping activity with M-AAA proteaseoverlapping with the m-AAA protease 1 homologzinc metallopeptidase	LIM and calponin homology domains-containing protein 1
	Modification date	20180519	20180519
	UniProtAcc	O75553	Q9UPQ0
	Ensembl transtripts involved in fusion gene	ENST00000485760, ENST00000371236, ENST00000371234, ENST00000420954, ENST00000439789, ENST00000414851, ENST00000371231, ENST00000371230,	ENST00000513024, ENST00000509638, ENST00000508501, ENST00000512946, ENST00000313860, ENST00000512632, ENST00000512820, ENST00000503057, ENST00000511496, ENST00000514096, ENST00000509277, ENST00000396595, ENST00000381753, ENST00000509454, ENST00000515785,
Fusion gene scores	* DoF score	10 X 9 X 3=270	10 X 10 X 6=600
	# samples	9	10
	** MAII score	log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/600*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DAB1 [Title/Abstract] AND LIMCH1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE173819	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000485760	ENST00000513024	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000485760	ENST00000509638	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000485760	ENST00000508501	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000485760	ENST00000512946	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000485760	ENST00000313860	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000485760	ENST00000512632	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000485760	ENST00000512820	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000485760	ENST00000503057	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000485760	ENST00000511496	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000485760	ENST00000514096	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000485760	ENST00000509277	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000485760	ENST00000396595	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000485760	ENST00000381753	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000485760	ENST00000509454	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000485760	ENST00000515785	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371236	ENST00000513024	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371236	ENST00000509638	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371236	ENST00000508501	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371236	ENST00000512946	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371236	ENST00000313860	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371236	ENST00000512632	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371236	ENST00000512820	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371236	ENST00000503057	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371236	ENST00000511496	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371236	ENST00000514096	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371236	ENST00000509277	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371236	ENST00000396595	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371236	ENST00000381753	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371236	ENST00000509454	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371236	ENST00000515785	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371234	ENST00000513024	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371234	ENST00000509638	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371234	ENST00000508501	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371234	ENST00000512946	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371234	ENST00000313860	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371234	ENST00000512632	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371234	ENST00000512820	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371234	ENST00000503057	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371234	ENST00000511496	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371234	ENST00000514096	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371234	ENST00000509277	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371234	ENST00000396595	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371234	ENST00000381753	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371234	ENST00000509454	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371234	ENST00000515785	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000420954	ENST00000513024	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000420954	ENST00000509638	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000420954	ENST00000508501	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000420954	ENST00000512946	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000420954	ENST00000313860	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000420954	ENST00000512632	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000420954	ENST00000512820	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000420954	ENST00000503057	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000420954	ENST00000511496	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000420954	ENST00000514096	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000420954	ENST00000509277	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000420954	ENST00000396595	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000420954	ENST00000381753	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000420954	ENST00000509454	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000420954	ENST00000515785	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000439789	ENST00000513024	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000439789	ENST00000509638	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000439789	ENST00000508501	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000439789	ENST00000512946	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000439789	ENST00000313860	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000439789	ENST00000512632	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000439789	ENST00000512820	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000439789	ENST00000503057	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000439789	ENST00000511496	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000439789	ENST00000514096	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000439789	ENST00000509277	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000439789	ENST00000396595	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000439789	ENST00000381753	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000439789	ENST00000509454	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000439789	ENST00000515785	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000414851	ENST00000513024	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000414851	ENST00000509638	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000414851	ENST00000508501	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000414851	ENST00000512946	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000414851	ENST00000313860	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000414851	ENST00000512632	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000414851	ENST00000512820	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000414851	ENST00000503057	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000414851	ENST00000511496	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000414851	ENST00000514096	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000414851	ENST00000509277	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000414851	ENST00000396595	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000414851	ENST00000381753	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000414851	ENST00000509454	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000414851	ENST00000515785	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371231	ENST00000513024	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371231	ENST00000509638	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371231	ENST00000508501	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371231	ENST00000512946	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371231	ENST00000313860	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371231	ENST00000512632	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371231	ENST00000512820	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371231	ENST00000503057	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371231	ENST00000511496	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371231	ENST00000514096	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371231	ENST00000509277	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371231	ENST00000396595	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371231	ENST00000381753	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371231	ENST00000509454	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371231	ENST00000515785	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371230	ENST00000513024	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371230	ENST00000509638	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371230	ENST00000508501	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371230	ENST00000512946	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371230	ENST00000313860	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371230	ENST00000512632	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371230	ENST00000512820	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371230	ENST00000503057	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371230	ENST00000511496	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371230	ENST00000514096	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371230	ENST00000509277	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371230	ENST00000396595	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-3UTR	ENST00000371230	ENST00000381753	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371230	ENST00000509454	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+
intron-intron	ENST00000371230	ENST00000515785	DAB1	chr1	59002223	-	LIMCH1	chr4	41700535	+

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FusionProtFeatures for DAB1_LIMCH1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DAB1 O75553	LIMCH1 Q9UPQ0

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for DAB1_LIMCH1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAB1_LIMCH1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for DAB1_LIMCH1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for DAB1_LIMCH1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DAB1	C0004352	Autistic Disorder	1	CTD_human
Tgene	LIMCH1	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	LIMCH1	C0345967	Malignant mesothelioma	1	CTD_human

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Fusion gene ID: 9230

FusionGeneSummary for DAB1_LIMCH1

FusionProtFeatures for DAB1_LIMCH1

FusionGeneSequence for DAB1_LIMCH1

FusionGenePPI for DAB1_LIMCH1

RelatedDrugs for DAB1_LIMCH1

RelatedDiseases for DAB1_LIMCH1