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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9220

FusionGeneSummary for DAAM1_IREB2

check button Fusion gene summary
Fusion gene informationFusion gene name: DAAM1_IREB2
Fusion gene ID: 9220
HgeneTgene
Gene symbol

DAAM1

IREB2

Gene ID

23002

3658

Gene namedishevelled associated activator of morphogenesis 1iron responsive element binding protein 2
Synonyms-ACO3|IRE-BP 2|IRE-BP2|IRP2|IRP2AD
Cytomap

14q23.1

15q25.1

Type of geneprotein-codingprotein-coding
Descriptiondisheveled-associated activator of morphogenesis 1iron-responsive element-binding protein 2iron regulatory protein 2
Modification date2018051920180519
UniProtAcc

Q9Y4D1

P48200

Ensembl transtripts involved in fusion geneENST00000360909, ENST00000351081, 
ENST00000395125, ENST00000556135, 
ENST00000553966, 
ENST00000258886, 
ENST00000560440, ENST00000559427, 
Fusion gene scores* DoF score8 X 7 X 5=2803 X 3 X 1=9
# samples 103
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DAAM1 [Title/Abstract] AND IREB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA502239DAAM1chr14

59655486

+IREB2chr15

78768528

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000360909ENST00000258886DAAM1chr14

59655486

+IREB2chr15

78768528

+
5UTR-3UTRENST00000360909ENST00000560440DAAM1chr14

59655486

+IREB2chr15

78768528

+
5UTR-intronENST00000360909ENST00000559427DAAM1chr14

59655486

+IREB2chr15

78768528

+
5UTR-3CDSENST00000351081ENST00000258886DAAM1chr14

59655486

+IREB2chr15

78768528

+
5UTR-3UTRENST00000351081ENST00000560440DAAM1chr14

59655486

+IREB2chr15

78768528

+
5UTR-intronENST00000351081ENST00000559427DAAM1chr14

59655486

+IREB2chr15

78768528

+
intron-3CDSENST00000395125ENST00000258886DAAM1chr14

59655486

+IREB2chr15

78768528

+
intron-3UTRENST00000395125ENST00000560440DAAM1chr14

59655486

+IREB2chr15

78768528

+
intron-intronENST00000395125ENST00000559427DAAM1chr14

59655486

+IREB2chr15

78768528

+
5UTR-3CDSENST00000556135ENST00000258886DAAM1chr14

59655486

+IREB2chr15

78768528

+
5UTR-3UTRENST00000556135ENST00000560440DAAM1chr14

59655486

+IREB2chr15

78768528

+
5UTR-intronENST00000556135ENST00000559427DAAM1chr14

59655486

+IREB2chr15

78768528

+
intron-3CDSENST00000553966ENST00000258886DAAM1chr14

59655486

+IREB2chr15

78768528

+
intron-3UTRENST00000553966ENST00000560440DAAM1chr14

59655486

+IREB2chr15

78768528

+
intron-intronENST00000553966ENST00000559427DAAM1chr14

59655486

+IREB2chr15

78768528

+

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FusionProtFeatures for DAAM1_IREB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAAM1

Q9Y4D1

IREB2

P48200

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as ascaffolding protein to recruit Rho-GDP and Rho-GEF, therebyenhancing Rho-GTP formation. Can direct nucleation and elongationof new actin filaments. Involved in building functional cilia(PubMed:16630611, PubMed:17482208). Involved in the organizationof the subapical actin network in multiciliated epithelial cells(By similarity). Together with DAAM2, required for myocardialmaturation and sarcomere assembly (By similarity).{ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0,ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAAM1_IREB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAAM1_IREB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DAAM1MAP3K7, PRPF40A, B3GALT4, AMBP, RHOD, GPN3, GNAZ, TMEM185A, PIFO, RHOA, CDH1, RHOC, FBXL16, SERHL2, RANBP6, FBXL14, TUBA4A, ARMC6, TUBB, SLC37A3, CHEK2, CHEK1IREB2YBX1, VHL, RBCK1, FBXL5, PSMA3, APP, TERT, USP53, CBS, TNPO1, UBA2, FAM96A, FAM96B, CIAO1, CAMKMT, CCNL2, INSL3, SLC9A3R1, SF1, KRAS, ARL15, ELAVL2, ENSA, ALDH3B1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAAM1_IREB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DAAM1_IREB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIREB2C0027626Neoplasm Invasiveness1CTD_human