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Fusion gene ID: 9220 |
FusionGeneSummary for DAAM1_IREB2 |
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Fusion gene information | Fusion gene name: DAAM1_IREB2 | Fusion gene ID: 9220 | Hgene | Tgene | Gene symbol | DAAM1 | IREB2 | Gene ID | 23002 | 3658 |
Gene name | dishevelled associated activator of morphogenesis 1 | iron responsive element binding protein 2 | |
Synonyms | - | ACO3|IRE-BP 2|IRE-BP2|IRP2|IRP2AD | |
Cytomap | 14q23.1 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | disheveled-associated activator of morphogenesis 1 | iron-responsive element-binding protein 2iron regulatory protein 2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9Y4D1 | P48200 | |
Ensembl transtripts involved in fusion gene | ENST00000360909, ENST00000351081, ENST00000395125, ENST00000556135, ENST00000553966, | ENST00000258886, ENST00000560440, ENST00000559427, | |
Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 3 X 3 X 1=9 |
# samples | 10 | 3 | |
** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DAAM1 [Title/Abstract] AND IREB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA502239 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000360909 | ENST00000258886 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
5UTR-3UTR | ENST00000360909 | ENST00000560440 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
5UTR-intron | ENST00000360909 | ENST00000559427 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
5UTR-3CDS | ENST00000351081 | ENST00000258886 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
5UTR-3UTR | ENST00000351081 | ENST00000560440 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
5UTR-intron | ENST00000351081 | ENST00000559427 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
intron-3CDS | ENST00000395125 | ENST00000258886 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
intron-3UTR | ENST00000395125 | ENST00000560440 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
intron-intron | ENST00000395125 | ENST00000559427 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
5UTR-3CDS | ENST00000556135 | ENST00000258886 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
5UTR-3UTR | ENST00000556135 | ENST00000560440 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
5UTR-intron | ENST00000556135 | ENST00000559427 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
intron-3CDS | ENST00000553966 | ENST00000258886 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
intron-3UTR | ENST00000553966 | ENST00000560440 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
intron-intron | ENST00000553966 | ENST00000559427 | DAAM1 | chr14 | 59655486 | + | IREB2 | chr15 | 78768528 | + |
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FusionProtFeatures for DAAM1_IREB2 |
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Hgene | Tgene |
DAAM1 | IREB2 |
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as ascaffolding protein to recruit Rho-GDP and Rho-GEF, therebyenhancing Rho-GTP formation. Can direct nucleation and elongationof new actin filaments. Involved in building functional cilia(PubMed:16630611, PubMed:17482208). Involved in the organizationof the subapical actin network in multiciliated epithelial cells(By similarity). Together with DAAM2, required for myocardialmaturation and sarcomere assembly (By similarity).{ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0,ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DAAM1_IREB2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DAAM1_IREB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DAAM1 | MAP3K7, PRPF40A, B3GALT4, AMBP, RHOD, GPN3, GNAZ, TMEM185A, PIFO, RHOA, CDH1, RHOC, FBXL16, SERHL2, RANBP6, FBXL14, TUBA4A, ARMC6, TUBB, SLC37A3, CHEK2, CHEK1 | IREB2 | YBX1, VHL, RBCK1, FBXL5, PSMA3, APP, TERT, USP53, CBS, TNPO1, UBA2, FAM96A, FAM96B, CIAO1, CAMKMT, CCNL2, INSL3, SLC9A3R1, SF1, KRAS, ARL15, ELAVL2, ENSA, ALDH3B1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DAAM1_IREB2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DAAM1_IREB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IREB2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |