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Fusion gene ID: 9211 |
FusionGeneSummary for CYTH3_SPARCL1 |
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Fusion gene information | Fusion gene name: CYTH3_SPARCL1 | Fusion gene ID: 9211 | Hgene | Tgene | Gene symbol | CYTH3 | SPARCL1 | Gene ID | 9265 | 8404 |
Gene name | cytohesin 3 | SPARC like 1 | |
Synonyms | ARNO3|GRP1|PSCD3|cytohesin-3 | MAST 9|MAST9|PIG33|SC1 | |
Cytomap | 7p22.1 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cytohesin-3ARF nucleotide-binding site opener 3PH, SEC7 and coiled-coil domain-containing protein 3general receptor of phosphoinositides 1pleckstrin homology, Sec7 and coiled-coil domains 3 | SPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O43739 | Q14515 | |
Ensembl transtripts involved in fusion gene | ENST00000350796, ENST00000396741, ENST00000488964, | ENST00000282470, ENST00000418378, ENST00000503414, | |
Fusion gene scores | * DoF score | 7 X 3 X 6=126 | 10 X 8 X 5=400 |
# samples | 7 | 11 | |
** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/400*10)=-1.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CYTH3 [Title/Abstract] AND SPARCL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-AJ-A3QS-01A | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000350796 | ENST00000282470 | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
5CDS-5UTR | ENST00000350796 | ENST00000418378 | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
5CDS-5UTR | ENST00000350796 | ENST00000503414 | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
intron-5UTR | ENST00000396741 | ENST00000282470 | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
intron-5UTR | ENST00000396741 | ENST00000418378 | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
intron-5UTR | ENST00000396741 | ENST00000503414 | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
intron-5UTR | ENST00000488964 | ENST00000282470 | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
intron-5UTR | ENST00000488964 | ENST00000418378 | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
intron-5UTR | ENST00000488964 | ENST00000503414 | CYTH3 | chr7 | 6312105 | - | SPARCL1 | chr4 | 88420737 | - |
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FusionProtFeatures for CYTH3_SPARCL1 |
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Hgene | Tgene |
CYTH3 | SPARCL1 |
Promotes guanine-nucleotide exchange on ARF1 and ARF6.Promotes the activation of ARF factors through replacement of GDPwith GTP. Play a role in the epithelial polarization (Bysimilarity). {ECO:0000250|UniProtKB:O08967,ECO:0000269|PubMed:23940353, ECO:0000269|PubMed:9707577}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CYTH3_SPARCL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CYTH3_SPARCL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CYTH3 | CNKSR1, CALCOCO1, IPCEF1, GNAQ, CCDC120, SYCE1, OIP5, WDR83, GPS2, CYTIP, FOSL2, PIK3CA, MTMR7, C1orf106, TRIM25 | SPARCL1 | EGFR, DISC1, SKIL |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CYTH3_SPARCL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CYTH3_SPARCL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SPARCL1 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | SPARCL1 | C0014544 | Epilepsy | 1 | CTD_human |