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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9179

FusionGeneSummary for CYP4Z2P_SPATA6

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP4Z2P_SPATA6
Fusion gene ID: 9179
HgeneTgene
Gene symbol

CYP4Z2P

SPATA6

Gene ID

163720

54558

Gene namecytochrome P450 family 4 subfamily Z member 2, pseudogenespermatogenesis associated 6
Synonyms-HASH|SRF-1|SRF1
Cytomap

1p33

1p33

Type of genepseudoprotein-coding
Descriptioncytochrome P450 4Z2 pseudogenecytochrome P450, family 4, subfamily Z, polypeptide 2, pseudogenespermatogenesis-associated protein 6spermatogenesis-related factor-1testicular tissue protein Li 178
Modification date2018032920180519
UniProtAcc

Q9NWH7

Ensembl transtripts involved in fusion geneENST00000505841, ENST00000371847, 
ENST00000371843, ENST00000396199, 
ENST00000463938, 
Fusion gene scores* DoF score2 X 1 X 1=24 X 3 X 4=48
# samples 24
** MAII scorelog2(2/2*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYP4Z2P [Title/Abstract] AND SPATA6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AC-A6IX-01ACYP4Z2Pchr1

47364515

-SPATA6chr1

48918803

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000505841ENST00000371847CYP4Z2Pchr1

47364515

-SPATA6chr1

48918803

-
5UTR-3CDSENST00000505841ENST00000371843CYP4Z2Pchr1

47364515

-SPATA6chr1

48918803

-
5UTR-5UTRENST00000505841ENST00000396199CYP4Z2Pchr1

47364515

-SPATA6chr1

48918803

-
5UTR-5UTRENST00000505841ENST00000463938CYP4Z2Pchr1

47364515

-SPATA6chr1

48918803

-

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FusionProtFeatures for CYP4Z2P_SPATA6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYP4Z2P

SPATA6

Q9NWH7

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Required for formation of the sperm connecting pieceduring spermiogenesis. Sperm connecting piece is essential forlinking the developing flagellum to the head during latespermiogenesis. May be involved in myosin-based microfilamenttransport through interaction with myosin subunits.{ECO:0000250|UniProtKB:Q3U6K5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYP4Z2P_SPATA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYP4Z2P_SPATA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CYP4Z2PSPATA6FUS, NEDD8-MDP1, DDB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYP4Z2P_SPATA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CYP4Z2P_SPATA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource