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Fusion gene ID: 9179 |
FusionGeneSummary for CYP4Z2P_SPATA6 |
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Fusion gene information | Fusion gene name: CYP4Z2P_SPATA6 | Fusion gene ID: 9179 | Hgene | Tgene | Gene symbol | CYP4Z2P | SPATA6 | Gene ID | 163720 | 54558 |
Gene name | cytochrome P450 family 4 subfamily Z member 2, pseudogene | spermatogenesis associated 6 | |
Synonyms | - | HASH|SRF-1|SRF1 | |
Cytomap | 1p33 | 1p33 | |
Type of gene | pseudo | protein-coding | |
Description | cytochrome P450 4Z2 pseudogenecytochrome P450, family 4, subfamily Z, polypeptide 2, pseudogene | spermatogenesis-associated protein 6spermatogenesis-related factor-1testicular tissue protein Li 178 | |
Modification date | 20180329 | 20180519 | |
UniProtAcc | Q9NWH7 | ||
Ensembl transtripts involved in fusion gene | ENST00000505841, | ENST00000371847, ENST00000371843, ENST00000396199, ENST00000463938, | |
Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 4 X 3 X 4=48 |
# samples | 2 | 4 | |
** MAII score | log2(2/2*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CYP4Z2P [Title/Abstract] AND SPATA6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AC-A6IX-01A | CYP4Z2P | chr1 | 47364515 | - | SPATA6 | chr1 | 48918803 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000505841 | ENST00000371847 | CYP4Z2P | chr1 | 47364515 | - | SPATA6 | chr1 | 48918803 | - |
5UTR-3CDS | ENST00000505841 | ENST00000371843 | CYP4Z2P | chr1 | 47364515 | - | SPATA6 | chr1 | 48918803 | - |
5UTR-5UTR | ENST00000505841 | ENST00000396199 | CYP4Z2P | chr1 | 47364515 | - | SPATA6 | chr1 | 48918803 | - |
5UTR-5UTR | ENST00000505841 | ENST00000463938 | CYP4Z2P | chr1 | 47364515 | - | SPATA6 | chr1 | 48918803 | - |
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FusionProtFeatures for CYP4Z2P_SPATA6 |
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Hgene | Tgene |
CYP4Z2P | SPATA6 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Required for formation of the sperm connecting pieceduring spermiogenesis. Sperm connecting piece is essential forlinking the developing flagellum to the head during latespermiogenesis. May be involved in myosin-based microfilamenttransport through interaction with myosin subunits.{ECO:0000250|UniProtKB:Q3U6K5}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CYP4Z2P_SPATA6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CYP4Z2P_SPATA6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CYP4Z2P | SPATA6 | FUS, NEDD8-MDP1, DDB2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CYP4Z2P_SPATA6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CYP4Z2P_SPATA6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |