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Fusion gene ID: 9178 |
FusionGeneSummary for CYP4Z1_ALYREF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYP4Z1_ALYREF | Fusion gene ID: 9178 | Hgene | Tgene | Gene symbol | CYP4Z1 | ALYREF | Gene ID | 199974 | 10189 |
| Gene name | cytochrome P450 family 4 subfamily Z member 1 | Aly/REF export factor | |
| Synonyms | CYP4A20 | ALY|ALY/REF|BEF|REF|THOC4 | |
| Cytomap | 1p33 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome P450 4Z1CYPIVZ1cytochrome P450, family 4, subfamily Z, polypeptide 1 | THO complex subunit 4THO complex 4ally of AML-1 and LEF-1bZIP enhancing factorbZIP-enhancing factor BEFtho4transcriptional coactivator Aly/REF | |
| Modification date | 20180331 | 20180522 | |
| UniProtAcc | Q86W10 | Q86V81 | |
| Ensembl transtripts involved in fusion gene | ENST00000334194, ENST00000471598, | ENST00000331204, ENST00000505490, ENST00000512673, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/8*10)=1.90689059560852 | |
| Context | PubMed: CYP4Z1 [Title/Abstract] AND ALYREF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ALYREF | GO:0046784 | viral mRNA export from host cell nucleus | 18974867 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-BC-A3KG-01A | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000334194 | ENST00000331204 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| Frame-shift | ENST00000334194 | ENST00000505490 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| 5CDS-5UTR | ENST00000334194 | ENST00000512673 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| intron-3CDS | ENST00000471598 | ENST00000331204 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| intron-3CDS | ENST00000471598 | ENST00000505490 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
| intron-5UTR | ENST00000471598 | ENST00000512673 | CYP4Z1 | chr1 | 47534435 | + | ALYREF | chr17 | 79848696 | - |
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FusionProtFeatures for CYP4Z1_ALYREF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYP4Z1 | ALYREF |
| Export adapter involved in nuclear export of spliced andunspliced mRNA. Binds mRNA which is thought to be transferred tothe NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Componentof the TREX complex which is thought to couple mRNA transcription,processing and nuclear export, and specifically associates withspliced mRNA and not with unspliced pre-mRNA. TREX is recruited tospliced mRNAs by a transcription-independent mechanism, binds tomRNA upstream of the exon-junction complex (EJC) and is recruitedin a splicing- and cap-dependent manner to a region near the 5'end of the mRNA where it functions in mRNA export to thecytoplasm. TREX recruitment occurs via an interaction betweenALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complexis essential for the export of Kaposi's sarcoma-associatedherpesvirus (KSHV) intronless mRNAs and infectious virusproduction; ALYREF/THOC4 mediates the recruitment of the TREXcomplex to the intronless viral mRNA. Required for TREX complexassembly and for linking DDX39B to the cap-binding complex (CBC).In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclearexport of HSP70 mRNA; both proteins enhance the RNA bindingactivity of NXF1 and are required for NXF1 localization to thenuclear rim. Involved in the nuclear export of intronless mRNA;proposed to be recruited to intronless mRNA by ATP-bound DDX39B.Involved in transcription elongation and genome stability.{ECO:0000269|PubMed:25662211}. Acts as chaperone and promotes the dimerization oftranscription factors containing basic leucine zipper (bZIP)domains and thereby promotes transcriptional activation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CYP4Z1_ALYREF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CYP4Z1_ALYREF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CYP4Z1 | ALYREF | DDX39A, DDX39B, LEF1, RUNX2, ALYREF, RBM8A, RRP1B, PCF11, MEPCE, DOT1L, H2AFX, UBC, RAD21, HDGF, ELAVL1, ARRB1, ARRB2, SIRT7, HNRNPA1, CUL3, CUL2, CUL1, COPS5, CAND1, NCBP1, THOC2, THOC5, THOC1, THOC3, THOC6, THOC7, ZC3H13, KIAA1429, ACIN1, SRRM1, SRRT, EFTUD2, RBM15, DDX3X, U2AF2, SRSF2, SRSF7, SRSF1, NR5A1, SMAD4, RBM15B, NXF1, GRK5, SF3B4, HNRNPM, YBX1, SRRM2, TLE3, WDR35, UGGT1, TRIP12, ATP6V1E1, TRIP13, UBA5, UBE2I, ERCC4, PAXIP1, EIF4A3, MAGOH, FN1, VCAM1, IL7R, ITGA4, CBX8, PAN2, CD81, IGSF8, ICAM1, FBXO6, STAU1, CEP250, NEDD1, AKT1, TP53, CUL7, OBSL1, SUZ12, EED, RNF2, CDK2, ILK, MARK3, PXK, SCYL2, SRPK1, TYK2, LUZP4, ESR1, PRMT8, DHX9, HSPA9, RBM34, SKIV2L, CSNK1E, GNL1, NAA16, NAP1L1, NOP2, PABPC1, PABPC4, XRN1, NTRK1, EWSR1, XPO1, HNRNPU, RPL10, BCLAF1, MATR3, FGFR1OP2, C17orf85, GLI1, NANOG, SFPQ, PRPF3, PRPF4, LSM4, LSM8, RPL26L1, SART3, PPIH, OLA1, RPL32, RNH1, CHCHD2, FAU, LSM6, NCL, CYLD, INO80B, CDK1, COQ2, COX15, HSD17B10, PARK7, PDHA1, SOAT1, FOXA1, TRIM25, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CYP4Z1_ALYREF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CYP4Z1_ALYREF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ALYREF | C0019693 | HIV Infections | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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