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Fusion gene ID: 9171 |
FusionGeneSummary for CYP4B1_NEDD4L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYP4B1_NEDD4L | Fusion gene ID: 9171 | Hgene | Tgene | Gene symbol | CYP4B1 | NEDD4L | Gene ID | 1580 | 23327 |
| Gene name | cytochrome P450 family 4 subfamily B member 1 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | |
| Synonyms | CYPIVB1|P-450HP | NEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2 | |
| Cytomap | 1p33 | 18q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome P450 4B1cytochrome P450, family 4, subfamily B, polypeptide 1cytochrome P450, subfamily IVB, polypeptide 1cytochrome P450-HPmicrosomal monooxygenase | E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lubiquitin-protein ligase Rsp5 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P13584 | Q96PU5 | |
| Ensembl transtripts involved in fusion gene | ENST00000546128, ENST00000371923, ENST00000271153, ENST00000371919, ENST00000452782, | ENST00000356462, ENST00000400345, ENST00000589054, ENST00000256832, ENST00000382850, ENST00000256830, ENST00000588516, ENST00000456986, ENST00000435432, ENST00000357895, ENST00000586263, ENST00000456173, ENST00000431212, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 13 X 14 X 6=1092 |
| # samples | 3 | 16 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(16/1092*10)=-2.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CYP4B1 [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NEDD4L | GO:0003254 | regulation of membrane depolarization | 15217910 |
| Tgene | NEDD4L | GO:0006511 | ubiquitin-dependent protein catabolic process | 21463633 |
| Tgene | NEDD4L | GO:0010038 | response to metal ion | 11244092 |
| Tgene | NEDD4L | GO:0016567 | protein ubiquitination | 15217910|25631046 |
| Tgene | NEDD4L | GO:0034765 | regulation of ion transmembrane transport | 17289006 |
| Tgene | NEDD4L | GO:0042391 | regulation of membrane potential | 17289006 |
| Tgene | NEDD4L | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 21463633 |
| Tgene | NEDD4L | GO:0060306 | regulation of membrane repolarization | 21463633 |
| Tgene | NEDD4L | GO:0070936 | protein K48-linked ubiquitination | 21463633 |
| Tgene | NEDD4L | GO:1901016 | regulation of potassium ion transmembrane transporter activity | 17289006 |
| Tgene | NEDD4L | GO:1901017 | negative regulation of potassium ion transmembrane transporter activity | 21463633 |
| Tgene | NEDD4L | GO:1901380 | negative regulation of potassium ion transmembrane transport | 21463633 |
| Tgene | NEDD4L | GO:1902306 | negative regulation of sodium ion transmembrane transport | 15217910 |
| Tgene | NEDD4L | GO:1903861 | positive regulation of dendrite extension | 23999003 |
| Tgene | NEDD4L | GO:2000009 | negative regulation of protein localization to cell surface | 21463633 |
| Tgene | NEDD4L | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 15217910 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG990991 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000546128 | ENST00000356462 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000400345 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000589054 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000256832 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000382850 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000256830 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000588516 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000456986 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000435432 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000357895 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000586263 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000456173 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000546128 | ENST00000431212 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000356462 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000400345 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000589054 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000256832 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000382850 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000256830 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000588516 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000456986 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000435432 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000357895 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000586263 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000456173 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371923 | ENST00000431212 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000356462 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000400345 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000589054 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000256832 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000382850 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000256830 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000588516 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000456986 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000435432 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000357895 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000586263 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000456173 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000271153 | ENST00000431212 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000356462 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000400345 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000589054 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000256832 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000382850 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000256830 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000588516 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000456986 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000435432 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000357895 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000586263 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000456173 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000371919 | ENST00000431212 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000356462 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000400345 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000589054 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000256832 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000382850 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000256830 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000588516 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000456986 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000435432 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000357895 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000586263 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000456173 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
| intron-intron | ENST00000452782 | ENST00000431212 | CYP4B1 | chr1 | 47283611 | - | NEDD4L | chr18 | 55959696 | - |
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FusionProtFeatures for CYP4B1_NEDD4L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYP4B1 | NEDD4L |
| Cytochromes P450 are a group of heme-thiolatemonooxygenases. In liver microsomes, this enzyme is involved in anNADPH-dependent electron transport pathway. It oxidizes a varietyof structurally unrelated compounds, including steroids, fattyacids, and xenobiotics. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CYP4B1_NEDD4L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CYP4B1_NEDD4L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CYP4B1_NEDD4L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CYP4B1_NEDD4L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CYP4B1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | NEDD4L | C0020538 | Hypertensive disease | 2 | CTD_human |
| Tgene | NEDD4L | C0008925 | Cleft Palate | 1 | CTD_human |
| Tgene | NEDD4L | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | NEDD4L | C0039075 | Syndactyly | 1 | CTD_human |
| Tgene | NEDD4L | C1868720 | Periventricular Nodular Heterotopia | 1 | CTD_human;ORPHANET |
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