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Fusion gene ID: 917 |
FusionGeneSummary for ADNP2_PARD6G |
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Fusion gene information | Fusion gene name: ADNP2_PARD6G | Fusion gene ID: 917 | Hgene | Tgene | Gene symbol | ADNP2 | PARD6G | Gene ID | 22850 | 84552 |
Gene name | ADNP homeobox 2 | par-6 family cell polarity regulator gamma | |
Synonyms | ZNF508 | PAR-6G|PAR6gamma | |
Cytomap | 18q23 | 18q23 | |
Type of gene | protein-coding | protein-coding | |
Description | activity-dependent neuroprotector homeobox protein 2ADNP homeobox protein 2zinc finger protein 508 | partitioning defective 6 homolog gammaPAR-6 gamma proteinPAR6Dpar-6 partitioning defective 6 homolog gamma | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6IQ32 | Q9BYG4 | |
Ensembl transtripts involved in fusion gene | ENST00000262198, | ENST00000353265, ENST00000470488, | |
Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 7 X 2 X 7=98 |
# samples | 3 | 7 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADNP2 [Title/Abstract] AND PARD6G [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-CS-5393-01A | ADNP2 | chr18 | 77867356 | + | PARD6G | chr18 | 77960815 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000262198 | ENST00000353265 | ADNP2 | chr18 | 77867356 | + | PARD6G | chr18 | 77960815 | - |
5UTR-3CDS | ENST00000262198 | ENST00000470488 | ADNP2 | chr18 | 77867356 | + | PARD6G | chr18 | 77960815 | - |
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FusionProtFeatures for ADNP2_PARD6G |
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Hgene | Tgene |
ADNP2 | PARD6G |
May be involved in transcriptional regulation. | Adapter protein involved in asymmetrical cell divisionand cell polarization processes. May play a role in the formationof epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADNP2_PARD6G |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADNP2_PARD6G |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADNP2 | NFYC, CBX1, CBX5, CBX3, ELAVL1, SHMT2, MOV10, NXF1, ITPKB, MYEF2 | PARD6G | PARD3, PRKCZ, RAC1, CDC42, YWHAH, PRKCI, LLGL1, YWHAE, PARD6B, MARK2, LLGL2, BRINP1, HSPA4, PNMA3, PNMA2, PNMAL1, WDR83, RHOJ |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADNP2_PARD6G |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADNP2_PARD6G |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADNP2 | C0036341 | Schizophrenia | 1 | PSYGENET |