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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9169

FusionGeneSummary for CYP4A11_SLC4A7

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP4A11_SLC4A7
Fusion gene ID: 9169
HgeneTgene
Gene symbol

CYP4A11

SLC4A7

Gene ID

1579

9497

Gene namecytochrome P450 family 4 subfamily A member 11solute carrier family 4 member 7
SynonymsCP4Y|CYP4A2|CYP4AII|CYPIVA11NBC2|NBC3|NBCN1|SBC2|SLC4A6
Cytomap

1p33

3p24.1

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 4A1120-HETE synthase20-hydroxyeicosatetraenoic acid synthaseP450HL-omegaalkane-1 monooxygenasecytochrome P-450HK-omegacytochrome P450, family 4, subfamily A, polypeptide 11cytochrome P450, subfamily IVA, polypeptide 11cytochrome P4sodium bicarbonate cotransporter 3bicarbonate transporterelectroneutral Na/HCO(3) cotransportersodium bicarbonate cotransporter 2sodium bicarbonate cotransporter 2bsolute carrier family 4, sodium bicarbonate cotransporter, member 7
Modification date2018052420180523
UniProtAcc

Q02928

Q9Y6M7

Ensembl transtripts involved in fusion geneENST00000310638, ENST00000371904, 
ENST00000462347, ENST00000371905, 
ENST00000496519, ENST00000457840, 
ENST00000435667, ENST00000440156, 
ENST00000455077, ENST00000437179, 
ENST00000388777, ENST00000454389, 
ENST00000446700, ENST00000425128, 
ENST00000445684, ENST00000428386, 
ENST00000295736, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 1=9
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/9*10)=2.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CYP4A11 [Title/Abstract] AND SLC4A7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYP4A11

GO:0001676

long-chain fatty acid metabolic process

18433732

HgeneCYP4A11

GO:0006691

leukotriene metabolic process

9799565

HgeneCYP4A11

GO:0019369

arachidonic acid metabolic process

10660572

HgeneCYP4A11

GO:0019373

epoxygenase P450 pathway

9618440

HgeneCYP4A11

GO:0055114

oxidation-reduction process

9618440|9799565|18433732


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W84867CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000310638ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000310638ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371904ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000462347ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000371905ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000496519ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000435667CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000440156CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000455077CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000437179CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000388777CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000454389CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000446700CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000425128CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000445684CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000428386CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-
intron-intronENST00000457840ENST00000295736CYP4A11chr1

47395580

-SLC4A7chr3

27523259

-

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FusionProtFeatures for CYP4A11_SLC4A7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYP4A11

Q02928

SLC4A7

Q9Y6M7

Catalyzes the omega- and (omega-1)-hydroxylation ofvarious fatty acids such as laurate, myristate and palmitate. Haslittle activity toward prostaglandins A1 and E1. Oxidizesarachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).{ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747,ECO:0000269|PubMed:7679927}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYP4A11_SLC4A7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYP4A11_SLC4A7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYP4A11_SLC4A7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CYP4A11_SLC4A7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource