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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9117

FusionGeneSummary for CYC1_FGA

check button Fusion gene summary
Fusion gene informationFusion gene name: CYC1_FGA
Fusion gene ID: 9117
HgeneTgene
Gene symbol

CYC1

FGA

Gene ID

10983

2243

Gene namecyclin Ifibrinogen alpha chain
SynonymsCCNI1|CYC1|CYIFib2
Cytomap

4q21.1

4q31.3

Type of geneprotein-codingprotein-coding
Descriptioncyclin-Icyclin ITIfibrinogen alpha chainfibrinogen, A alpha polypeptide
Modification date2018052320180520
UniProtAcc

P08574

P02671

Ensembl transtripts involved in fusion geneENST00000318911, ENST00000302053, 
ENST00000403106, 
Fusion gene scores* DoF score5 X 5 X 4=1003 X 3 X 2=18
# samples 53
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CYC1 [Title/Abstract] AND FGA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGA

GO:0007160

cell-matrix adhesion

10903502

TgeneFGA

GO:0031639

plasminogen activation

16846481

TgeneFGA

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

TgeneFGA

GO:0034622

cellular protein-containing complex assembly

8910396

TgeneFGA

GO:0042730

fibrinolysis

16846481

TgeneFGA

GO:0043152

induction of bacterial agglutination

24367264

TgeneFGA

GO:0045907

positive regulation of vasoconstriction

15739255

TgeneFGA

GO:0045921

positive regulation of exocytosis

19193866

TgeneFGA

GO:0050714

positive regulation of protein secretion

19193866

TgeneFGA

GO:0051258

protein polymerization

12706644

TgeneFGA

GO:0051592

response to calcium ion

6777381

TgeneFGA

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

TgeneFGA

GO:0070527

platelet aggregation

6281794

TgeneFGA

GO:0072378

blood coagulation, fibrin clot formation

16846481

TgeneFGA

GO:0090277

positive regulation of peptide hormone secretion

19193866

TgeneFGA

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

TgeneFGA

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-ZP-A9D0-01ACYC1chr8

145151153

+FGAchr4

155508070

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000318911ENST00000302053CYC1chr8

145151153

+FGAchr4

155508070

-
Frame-shiftENST00000318911ENST00000403106CYC1chr8

145151153

+FGAchr4

155508070

-

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FusionProtFeatures for CYC1_FGA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYC1

P08574

FGA

P02671

This is the heme-containing component of the cytochromeb-c1 complex, which accepts electrons from Rieske protein andtransfers electrons to cytochrome c in the mitochondrialrespiratory chain. Cleaved by the protease thrombin to yield monomerswhich, together with fibrinogen beta (FGB) and fibrinogen gamma(FGG), polymerize to form an insoluble fibrin matrix. Fibrin has amajor function in hemostasis as one of the primary components ofblood clots. In addition, functions during the early stages ofwound repair to stabilize the lesion and guide cell migrationduring re-epithelialization. Was originally thought to beessential for platelet aggregation, based on in vitro studiesusing anticoagulated blood. However, subsequent studies have shownthat it is not absolutely required for thrombus formation in vivo.Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successfulpregnancy. Fibrin deposition is also associated with infection,where it protects against IFNG-mediated hemorrhage. May alsofacilitate the immune response via both innate and T-cell mediatedpathways. {ECO:0000250|UniProtKB:E9PV24}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFGAchr8:145151153chr4:155508070ENST00000302053-36623_864170867DomainFibrinogen C-terminal
TgeneFGAchr8:145151153chr4:155508070ENST00000403106-35623_864170645DomainFibrinogen C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYC1chr8:145151153chr4:155508070ENST00000318911+37108_209151326DomainNote=Cytochrome c
HgeneCYC1chr8:145151153chr4:155508070ENST00000318911+37292_306151326TransmembraneHelical%3B Note%3DAnchors to the membrane
TgeneFGAchr8:145151153chr4:155508070ENST00000302053-3668_631170867Coiled coilOntology_term=ECO:0000305
TgeneFGAchr8:145151153chr4:155508070ENST00000403106-3568_631170645Coiled coilOntology_term=ECO:0000305
TgeneFGAchr8:145151153chr4:155508070ENST00000302053-3636_38170867RegionNote=Alpha-chain polymerization%2C binding distal domain of another fibrin gamma chain
TgeneFGAchr8:145151153chr4:155508070ENST00000403106-3536_38170645RegionNote=Alpha-chain polymerization%2C binding distal domain of another fibrin gamma chain


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FusionGeneSequence for CYC1_FGA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CYC1_ENST00000318911_chr8_145151153_+_FGA_ENST00000302053_chr4_155508070_-_848aa
MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLAMALHSAVSASDLELH
PPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVDIDIKIRSCRGSCSRALAREVDLKDYED
QQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNP
SSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSV
SGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTV
IGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKE
SSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFN
IKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAE
YHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CYC1_ENST00000318911_chr8_145151153_+_FGA_ENST00000302053_chr4_155508070_-_2544nt
ATGGCGGCAGCTGCGGCTTCGCTTCGCGGGGTAGTGTTGGGCCCGCGGGGCGCGGGGCTCCCGGGCGCGCGTGCCCGGGGTCTGCTGTGC
AGCGCGCGTCCCGGGCAGCTCCCGCTACGGACACCTCAGGCAGTGGCCTTGTCGTCGAAGTCTGGCCTTTCCCGAGGCCGGAAAGTGATG
CTGTCAGCGCTGGGCATGCTGGCGGCAGGGGGTGCGGGGCTGGCCATGGCTCTGCATTCGGCTGTGAGTGCCAGTGACCTGGAGCTGCAC
CCCCCCAGCTATCCGTGGTCTCACCGTGGCCTCCTCTCTTCCTTGGACCACACCAGCATCCGGAGGGGTTTCCAGGTATATAAGCAGGTG
TGCGCCTCCTGCCACAGCATGGACTTCGTGGCCTACCGCCACCTGGTGGGCGTGTGCTACACGGAGGATGAAGCTAAGGAGCTGGCTGCG
GAGGTGGACATTGATATTAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCTTTAGCTCGTGAAGTAGATCTGAAGGACTATGAAGAT
CAGCAGAAGCAACTTGAACAGGTCATTGCCAAAGACTTACTTCCCTCTAGAGATAGGCAACACTTACCACTGATAAAAATGAAACCAGTT
CCAGACTTGGTTCCCGGAAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTGGAAGGCATTAACAGACATGCCGCAGATGAGAATG
GAGTTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAGGCTCCACCTCTTATGGAACCGGATCAGAGACGGAAAGCCCCAGGAACCCT
AGCAGTGCTGGAAGCTGGAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCGAAACCCTGGGAGCTCTGGGACTGGAGGGACTGCA
ACCTGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTGGGAGCTCTGGAACTGGAAGTACTGGAAACCAAAACCCT
GGGAGCCCTAGACCTGGTAGTACCGGAACCTGGAATCCTGGCAGCTCTGAACGCGGAAGTGCTGGGCACTGGACCTCTGAGAGCTCTGTA
TCTGGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCCAGGCTCTGGGAACGCGAGGCCTAACAACCCAGAC
TGGGGCACATTTGAAGAGGTGTCAGGAAATGTAAGTCCAGGGACAAGGAGAGAGTACCACACAGAAAAACTGGTCACTTCTAAAGGAGAT
AAAGAGCTCAGGACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCGTCGTTCATGCTCTAAAACCGTTACTAAGACTGTT
ATTGGTCCTGATGGTCACAAAGAAGTTACCAAAGAAGTGGTGACCTCCGAAGATGGTTCTGACTGTCCCGAGGCAATGGATTTAGGCACA
TTGTCTGGCATAGGTACTCTGGATGGGTTCCGCCATAGGCACCCTGATGAAGCTGCCTTCTTCGACACTGCCTCAACTGGAAAAACATTC
CCAGGTTTCTTCTCACCTATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGGCTCAGAATCTGGCATCTTCACAAATACAAAGGAA
TCCAGTTCTCATCACCCTGGGATAGCTGAATTCCCTTCCCGTGGTAAATCTTCAAGTTACAGCAAACAATTTACTAGTAGCACGAGTTAC
AACAGAGGAGACTCCACATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGGAAGTGAAGCCGATCATGAAGGAACACATAGCACC
AAGAGAGGCCATGCTAAATCTCGCCCTGTCAGAGACTGTGATGATGTCCTCCAAACACATCCTTCAGGTACCCAAAGTGGCATTTTCAAT
ATCAAGCTACCGGGATCCAGTAAGATTTTTTCTGTTTATTGCGATCAAGAGACCAGTTTGGGAGGATGGCTTTTGATCCAGCAAAGAATG
GATGGATCACTGAATTTTAACCGGACCTGGCAAGACTACAAGAGAGGTTTCGGCAGCCTGAATGACGAGGGGGAAGGAGAATTCTGGCTA
GGCAATGACTACCTCCACTTACTAACCCAAAGGGGCTCTGTTCTTAGGGTTGAATTAGAGGACTGGGCTGGGAATGAAGCTTATGCAGAA
TATCACTTCCGGGTAGGCTCTGAGGCTGAAGGCTATGCCCTCCAAGTCTCCTCCTATGAAGGCACTGCGGGTGATGCTCTGATTGAGGGT
TCCGTAGAGGAAGGGGCAGAGTACACCTCTCACAACAACATGCAGTTCAGCACCTTTGACAGGGATGCAGACCAGTGGGAAGAGAACTGT
GCAGAAGTCTATGGGGGAGGCTGGTGGTATAATAACTGCCAAGCAGCCAATCTCAATGGAATCTACTACCCTGGGGGCTCCTATGACCCA
AGGAATAACAGTCCTTATGAGATTGAGAATGGAGTGGTCTGGGTTTCCTTTAGAGGGGCAGATTATTCCCTCAGGGCTGTTCGCATGAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CYC1_ENST00000318911_chr8_145151153_+_FGA_ENST00000302053_chr4_155508070_-_3615nt
GCTTTCGCGAGGTTTTGACTCTCGTGGCGCCCCAGGGGCCGACGGGAGTGGCGGCCGCGCGGAGGAGGCCAAGATGGCGGCAGCTGCGGC
TTCGCTTCGCGGGGTAGTGTTGGGCCCGCGGGGCGCGGGGCTCCCGGGCGCGCGTGCCCGGGGTCTGCTGTGCAGCGCGCGTCCCGGGCA
GCTCCCGCTACGGACACCTCAGGCAGTGGCCTTGTCGTCGAAGTCTGGCCTTTCCCGAGGCCGGAAAGTGATGCTGTCAGCGCTGGGCAT
GCTGGCGGCAGGGGGTGCGGGGCTGGCCATGGCTCTGCATTCGGCTGTGAGTGCCAGTGACCTGGAGCTGCACCCCCCCAGCTATCCGTG
GTCTCACCGTGGCCTCCTCTCTTCCTTGGACCACACCAGCATCCGGAGGGGTTTCCAGGTATATAAGCAGGTGTGCGCCTCCTGCCACAG
CATGGACTTCGTGGCCTACCGCCACCTGGTGGGCGTGTGCTACACGGAGGATGAAGCTAAGGAGCTGGCTGCGGAGGTGGACATTGATAT
TAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCTTTAGCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAGCAGAAGCAACTTGA
ACAGGTCATTGCCAAAGACTTACTTCCCTCTAGAGATAGGCAACACTTACCACTGATAAAAATGAAACCAGTTCCAGACTTGGTTCCCGG
AAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTGGAAGGCATTAACAGACATGCCGCAGATGAGAATGGAGTTAGAGAGACCTGG
TGGAAATGAGATTACTCGAGGAGGCTCCACCTCTTATGGAACCGGATCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAGCTG
GAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCGAAACCCTGGGAGCTCTGGGACTGGAGGGACTGCAACCTGGAAACCTGGGAG
CTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTGGGAGCTCTGGAACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGG
TAGTACCGGAACCTGGAATCCTGGCAGCTCTGAACGCGGAAGTGCTGGGCACTGGACCTCTGAGAGCTCTGTATCTGGTAGTACTGGACA
ATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCCAGGCTCTGGGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGA
GGTGTCAGGAAATGTAAGTCCAGGGACAAGGAGAGAGTACCACACAGAAAAACTGGTCACTTCTAAAGGAGATAAAGAGCTCAGGACTGG
TAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCGTCGTTCATGCTCTAAAACCGTTACTAAGACTGTTATTGGTCCTGATGGTCA
CAAAGAAGTTACCAAAGAAGTGGTGACCTCCGAAGATGGTTCTGACTGTCCCGAGGCAATGGATTTAGGCACATTGTCTGGCATAGGTAC
TCTGGATGGGTTCCGCCATAGGCACCCTGATGAAGCTGCCTTCTTCGACACTGCCTCAACTGGAAAAACATTCCCAGGTTTCTTCTCACC
TATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGGCTCAGAATCTGGCATCTTCACAAATACAAAGGAATCCAGTTCTCATCACCC
TGGGATAGCTGAATTCCCTTCCCGTGGTAAATCTTCAAGTTACAGCAAACAATTTACTAGTAGCACGAGTTACAACAGAGGAGACTCCAC
ATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGGAAGTGAAGCCGATCATGAAGGAACACATAGCACCAAGAGAGGCCATGCTAA
ATCTCGCCCTGTCAGAGACTGTGATGATGTCCTCCAAACACATCCTTCAGGTACCCAAAGTGGCATTTTCAATATCAAGCTACCGGGATC
CAGTAAGATTTTTTCTGTTTATTGCGATCAAGAGACCAGTTTGGGAGGATGGCTTTTGATCCAGCAAAGAATGGATGGATCACTGAATTT
TAACCGGACCTGGCAAGACTACAAGAGAGGTTTCGGCAGCCTGAATGACGAGGGGGAAGGAGAATTCTGGCTAGGCAATGACTACCTCCA
CTTACTAACCCAAAGGGGCTCTGTTCTTAGGGTTGAATTAGAGGACTGGGCTGGGAATGAAGCTTATGCAGAATATCACTTCCGGGTAGG
CTCTGAGGCTGAAGGCTATGCCCTCCAAGTCTCCTCCTATGAAGGCACTGCGGGTGATGCTCTGATTGAGGGTTCCGTAGAGGAAGGGGC
AGAGTACACCTCTCACAACAACATGCAGTTCAGCACCTTTGACAGGGATGCAGACCAGTGGGAAGAGAACTGTGCAGAAGTCTATGGGGG
AGGCTGGTGGTATAATAACTGCCAAGCAGCCAATCTCAATGGAATCTACTACCCTGGGGGCTCCTATGACCCAAGGAATAACAGTCCTTA
TGAGATTGAGAATGGAGTGGTCTGGGTTTCCTTTAGAGGGGCAGATTATTCCCTCAGGGCTGTTCGCATGAAAATTAGGCCCCTTGTGAC
CCAATAGGCTGAAGAAGTGGGAATGGGAGCACTCTGTCTTCTTTGCTAGAGAAGTGGAGAGAAAATACAAAAGGTAAAGCAGTTGAGATT
CTCTACAACCTAAAAAATTCCTAGGTGCTATTTTCTTATCCTTTGTACTGTAGCTAAATGTACCTGAGACATATTAGTCTTTGAAAAATA
AAGTTATGTAAGGTTTTTTTTATCTTTAAATAGCTCTGTGGGTTTTAACATTTTTATAAAGATATACCAAGGGCCATTCAGTACATCAGG
AAAGTGGCAGACAGAAGCTTCTCTCTGCAACCTTGAAGACTATTGGTTTGAGAACTTCTCTTCCCATACCACCCAAAATCATAATGCCAT
TGGAAAGCAAAAAGTTGTTTTATCCATTTGATTTGAATTGTTTTAAGCCAATATTTTAAGGTAAAACTCACTGAATCTAACCATAGCTGA
CCTTTGTAGTAGAATTTACAACTTATAATTACAATGCACAATTTATAATTACAATATGTATTTATGTCTTTTGCTATGGAGCAAATCCAG
GAAGGCAAGAGAAACATTCTTTCCTAAATATAAATGAAAATCTATCCTTTAAACTCTTCCACTAGACGTTGTAATGCACACTTATTTTTT
TCCCAAGGAGTAACCAATTTCTTTCTAAAACACATTTAAAATTTTAAAACTATTTATGAATATTAAAAAAAGACATAATTCACACATTAA
TAAACAATCTCCCAAGTATTGATTTAACTTCATTTTTCTAATAATCATAAACTATATTCTGTGACATGCTAATTATTATTAAATGTAAGT
CGTTAGTTCGAAAGCCTCTCACTAAGTATGATCTATGCTATATTCAAAATTCAACCCATTTACTTTGGTCAATATTTGATCTAAGTTGCA
TCTTTAATCCTGGTGGTCTTGCCTTCTGATTTTTAATTTGTATCCTTTTCTATTAAGATATATTTGTCATTTTCTCTTGAATATGTATTA


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FusionGenePPI for CYC1_FGA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CYC1CYCS, CLN3, NDUFS4, NDUFS8, ATP5A1, NDUFA12, NDUFB10, SURF1, DHODH, MRPL4, NDUFAF3, SAMM50, COX15, SSBP1, RPUSD4, MRPL15, ICT1, TAP1, ECT2, MYC, ATF2, FBXO6, ASB14, MOV10, HCCS, PEX19, UQCR10, UQCRB, AFG3L2, ATAD3A, ATAD3B, ATP5I, ATP5O, CLTC, ACTN1, ACTN4, ATP1A1, ATP1B1, ATP1B3, ATP5H, ATP5L, CANX, COX5A, DLAT, ILVBL, LMAN1, MYL6, OGDH, RAB1A, RAB1B, RCN1, RPN1, SDHA, SSR1, TMCO1, TOMM40, TPM3, UQCRFS1, HSD17B12, MRPL37, CYTB, MYH7B, NDUFS3, PHB, PHB2, PPP2R1A, SGPL1, SLC25A3, VDAC1, VDAC2, VDAC3, NTRK1, GOLT1B, NDUFA4, ZNF746, EYA2, MTMR12, UQCRH, TPTEFGAPRRC2A, F2, FGG, FGB, PLAT, NID1, F13A1, HRG, THBS1, CDH5, FGA, KHDRBS2, MIS12, UBC, APOA1, ALB, FN1, ASB6, ASB7, DDX19B, ALDH2, TRIM33, FBXW7, HIST1H2BJ, RING1, SNX27, MAPK6, ITGA2B, ITGB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYC1_FGA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGAP02671DB00009AlteplaseFibrinogen alpha chainbiotechapproved
TgeneFGAP02671DB00029AnistreplaseFibrinogen alpha chainbiotechapproved
TgeneFGAP02671DB00031TenecteplaseFibrinogen alpha chainbiotechapproved
TgeneFGAP02671DB00364SucralfateFibrinogen alpha chainsmall moleculeapproved
TgeneFGAP02671DB00015ReteplaseFibrinogen alpha chainbiotechapproved|investigational
TgeneFGAP02671DB01593ZincFibrinogen alpha chainsmall moleculeapproved|investigational
TgeneFGAP02671DB05099AncrodFibrinogen alpha chainsmall moleculeapproved|investigational
TgeneFGAP02671DB13151Anti-inhibitor coagulant complexFibrinogen alpha chainbiotechapproved|investigational

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RelatedDiseases for CYC1_FGA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYC1C3809553MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 61UNIPROT
TgeneFGAC0001733Afibrinogenemia4CTD_human
TgeneFGAC0022658Kidney Diseases2CTD_human;HPO
TgeneFGAC0272350Dysfibrinogenemia, Congenital2ORPHANET;UNIPROT
TgeneFGAC0740340Amyloidosis, Familial2CTD_human
TgeneFGAC0008370Cholestasis1CTD_human;HPO
TgeneFGAC0026640Mouth Neoplasms1CTD_human
TgeneFGAC0029456Osteoporosis1CTD_human
TgeneFGAC0034065Pulmonary Embolism1CTD_human
TgeneFGAC0040053Thrombosis1CTD_human
TgeneFGAC0041755Adverse reaction to drug1CTD_human
TgeneFGAC0268389Amyloidosis, familial visceral1CTD_human;UNIPROT
TgeneFGAC0398623Thrombophilia1CTD_human
TgeneFGAC1861172Venous Thromboembolism1CTD_human
TgeneFGAC2584774Congenital hypofibrinogenemia1ORPHANET;UNIPROT
TgeneFGAC4277682Chemical and Drug Induced Liver Injury1CTD_human