![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 9112 |
FusionGeneSummary for CYBB_ADAM10 |
![]() |
Fusion gene information | Fusion gene name: CYBB_ADAM10 | Fusion gene ID: 9112 | Hgene | Tgene | Gene symbol | CYBB | ADAM10 | Gene ID | 1536 | 102 |
Gene name | cytochrome b-245 beta chain | ADAM metallopeptidase domain 10 | |
Synonyms | AMCBX2|CGD|GP91-1|GP91-PHOX|GP91PHOX|IMD34|NOX2|p91-PHOX | AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz | |
Cytomap | Xp21.1-p11.4 | 15q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cytochrome b-245 heavy chainCGD91-phoxNADPH oxidase 2cytochrome b(558) subunit betacytochrome b-245 beta polypeptidecytochrome b558 subunit betaheme-binding membrane glycoprotein gp91phoxneutrophil cytochrome b 91 kDa polypeptidep22 phagocyte B-cy | disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P04839 | O14672 | |
Ensembl transtripts involved in fusion gene | ENST00000378588, ENST00000545017, ENST00000536160, ENST00000492288, | ENST00000260408, ENST00000402627, ENST00000561288, ENST00000396140, ENST00000558733, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CYBB [Title/Abstract] AND ADAM10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CYBB | GO:0006801 | superoxide metabolic process | 12042318 |
Hgene | CYBB | GO:0042554 | superoxide anion generation | 12042318 |
Hgene | CYBB | GO:0055114 | oxidation-reduction process | 12042318 |
Tgene | ADAM10 | GO:0006509 | membrane protein ectodomain proteolysis | 12714508|17557115|18355449|18419754|18676862|19114711 |
Tgene | ADAM10 | GO:0007162 | negative regulation of cell adhesion | 12714508 |
Tgene | ADAM10 | GO:0034612 | response to tumor necrosis factor | 11831872 |
Tgene | ADAM10 | GO:0051089 | constitutive protein ectodomain proteolysis | 12714508 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | Z48614 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000378588 | ENST00000260408 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000378588 | ENST00000402627 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000378588 | ENST00000561288 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000378588 | ENST00000396140 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000378588 | ENST00000558733 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-3CDS | ENST00000545017 | ENST00000260408 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000545017 | ENST00000402627 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000545017 | ENST00000561288 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000545017 | ENST00000396140 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000545017 | ENST00000558733 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-3CDS | ENST00000536160 | ENST00000260408 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000536160 | ENST00000402627 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000536160 | ENST00000561288 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000536160 | ENST00000396140 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000536160 | ENST00000558733 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-3CDS | ENST00000492288 | ENST00000260408 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000492288 | ENST00000402627 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000492288 | ENST00000561288 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000492288 | ENST00000396140 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
intron-intron | ENST00000492288 | ENST00000558733 | CYBB | chrX | 37669885 | - | ADAM10 | chr15 | 58913713 | - |
Top |
FusionProtFeatures for CYBB_ADAM10 |
![]() |
Hgene | Tgene |
CYBB | ADAM10 |
Critical component of the membrane-bound oxidase ofphagocytes that generates superoxide. It is the terminal componentof a respiratory chain that transfers single electrons fromcytoplasmic NADPH across the plasma membrane to molecular oxygenon the exterior. Also functions as a voltage-gated proton channelthat mediates the H(+) currents of resting phagocytes. Itparticipates in the regulation of cellular pH and is blocked byzinc. | Cleaves the membrane-bound precursor of TNF-alpha at'76-Ala-|-Val-77' to its mature soluble form. Responsible for theproteolytical release of soluble JAM3 from endothelial cellssurface (PubMed:20592283). Responsible for the proteolytic releaseof several other cell-surface proteins, including heparin-bindingepidermal growth-like factor, ephrin-A2, CD44, CDH2 and forconstitutive and regulated alpha-secretase cleavage of amyloidprecursor protein (APP) (PubMed:26686862, PubMed:11786905,PubMed:29224781). Contributes to the normal cleavage of thecellular prion protein (PubMed:11477090). Involved in the cleavageof the adhesion molecule L1 at the cell surface and in releasedmembrane vesicles, suggesting a vesicle-based protease activity(PubMed:12475894). Controls also the proteolytic processing ofNotch and mediates lateral inhibition during neurogenesis (Bysimilarity). Responsible for the FasL ectodomain shedding and forthe generation of the remnant ADAM10-processed FasL (FasL APL)transmembrane form (PubMed:17557115). Also cleaves the ectodomainof the integral membrane proteins CORIN and ITM2B(PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3signaling (PubMed:16239146). {ECO:0000250|UniProtKB:O35598,ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905,ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146,ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711,ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900,ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29224781}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CYBB_ADAM10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CYBB_ADAM10 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CYBB_ADAM10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CYBB | P04839 | DB00514 | Dextromethorphan | Cytochrome b-245 heavy chain | small molecule | approved |
Top |
RelatedDiseases for CYBB_ADAM10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CYBB | C1844376 | Granulomatous Disease, Chronic, X-Linked | 20 | UNIPROT |
Hgene | CYBB | C0018203 | Chronic granulomatous disease | 2 | CTD_human;ORPHANET |
Hgene | CYBB | C0020538 | Hypertensive disease | 2 | CTD_human |
Hgene | CYBB | C0011849 | Diabetes Mellitus | 1 | CTD_human |
Hgene | CYBB | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Hgene | CYBB | C0018801 | Heart failure | 1 | CTD_human |
Hgene | CYBB | C0022658 | Kidney Diseases | 1 | CTD_human |
Hgene | CYBB | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | CYBB | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | CYBB | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
Hgene | CYBB | C0033687 | Proteinuria | 1 | CTD_human |
Hgene | CYBB | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | CYBB | C0751955 | Brain Infarction | 1 | CTD_human |
Hgene | CYBB | C1970859 | Atypical Mycobacteriosis, Familial, X-Linked 2 | 1 | ORPHANET;UNIPROT |
Tgene | ADAM10 | C3810041 | ALZHEIMER DISEASE 18 | 2 | UNIPROT |
Tgene | ADAM10 | C0406811 | Reticulate acropigmentation of Kitamura | 1 | ORPHANET;UNIPROT |
Tgene | ADAM10 | C1458155 | Mammary Neoplasms | 1 | CTD_human |