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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9112

FusionGeneSummary for CYBB_ADAM10

check button Fusion gene summary
Fusion gene informationFusion gene name: CYBB_ADAM10
Fusion gene ID: 9112
HgeneTgene
Gene symbol

CYBB

ADAM10

Gene ID

1536

102

Gene namecytochrome b-245 beta chainADAM metallopeptidase domain 10
SynonymsAMCBX2|CGD|GP91-1|GP91-PHOX|GP91PHOX|IMD34|NOX2|p91-PHOXAD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz
Cytomap

Xp21.1-p11.4

15q21.3

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b-245 heavy chainCGD91-phoxNADPH oxidase 2cytochrome b(558) subunit betacytochrome b-245 beta polypeptidecytochrome b558 subunit betaheme-binding membrane glycoprotein gp91phoxneutrophil cytochrome b 91 kDa polypeptidep22 phagocyte B-cydisintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease
Modification date2018052220180519
UniProtAcc

P04839

O14672

Ensembl transtripts involved in fusion geneENST00000378588, ENST00000545017, 
ENST00000536160, ENST00000492288, 
ENST00000260408, ENST00000402627, 
ENST00000561288, ENST00000396140, 
ENST00000558733, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 4=64
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYBB [Title/Abstract] AND ADAM10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYBB

GO:0006801

superoxide metabolic process

12042318

HgeneCYBB

GO:0042554

superoxide anion generation

12042318

HgeneCYBB

GO:0055114

oxidation-reduction process

12042318

TgeneADAM10

GO:0006509

membrane protein ectodomain proteolysis

12714508|17557115|18355449|18419754|18676862|19114711

TgeneADAM10

GO:0007162

negative regulation of cell adhesion

12714508

TgeneADAM10

GO:0034612

response to tumor necrosis factor

11831872

TgeneADAM10

GO:0051089

constitutive protein ectodomain proteolysis

12714508


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1Z48614CYBBchrX

37669885

-ADAM10chr15

58913713

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000378588ENST00000260408CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000378588ENST00000402627CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000378588ENST00000561288CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000378588ENST00000396140CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000378588ENST00000558733CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-3CDSENST00000545017ENST00000260408CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000545017ENST00000402627CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000545017ENST00000561288CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000545017ENST00000396140CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000545017ENST00000558733CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-3CDSENST00000536160ENST00000260408CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000536160ENST00000402627CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000536160ENST00000561288CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000536160ENST00000396140CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000536160ENST00000558733CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-3CDSENST00000492288ENST00000260408CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000492288ENST00000402627CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000492288ENST00000561288CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000492288ENST00000396140CYBBchrX

37669885

-ADAM10chr15

58913713

-
intron-intronENST00000492288ENST00000558733CYBBchrX

37669885

-ADAM10chr15

58913713

-

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FusionProtFeatures for CYBB_ADAM10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYBB

P04839

ADAM10

O14672

Critical component of the membrane-bound oxidase ofphagocytes that generates superoxide. It is the terminal componentof a respiratory chain that transfers single electrons fromcytoplasmic NADPH across the plasma membrane to molecular oxygenon the exterior. Also functions as a voltage-gated proton channelthat mediates the H(+) currents of resting phagocytes. Itparticipates in the regulation of cellular pH and is blocked byzinc. Cleaves the membrane-bound precursor of TNF-alpha at'76-Ala-|-Val-77' to its mature soluble form. Responsible for theproteolytical release of soluble JAM3 from endothelial cellssurface (PubMed:20592283). Responsible for the proteolytic releaseof several other cell-surface proteins, including heparin-bindingepidermal growth-like factor, ephrin-A2, CD44, CDH2 and forconstitutive and regulated alpha-secretase cleavage of amyloidprecursor protein (APP) (PubMed:26686862, PubMed:11786905,PubMed:29224781). Contributes to the normal cleavage of thecellular prion protein (PubMed:11477090). Involved in the cleavageof the adhesion molecule L1 at the cell surface and in releasedmembrane vesicles, suggesting a vesicle-based protease activity(PubMed:12475894). Controls also the proteolytic processing ofNotch and mediates lateral inhibition during neurogenesis (Bysimilarity). Responsible for the FasL ectodomain shedding and forthe generation of the remnant ADAM10-processed FasL (FasL APL)transmembrane form (PubMed:17557115). Also cleaves the ectodomainof the integral membrane proteins CORIN and ITM2B(PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3signaling (PubMed:16239146). {ECO:0000250|UniProtKB:O35598,ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905,ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146,ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711,ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900,ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29224781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYBB_ADAM10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYBB_ADAM10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYBB_ADAM10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCYBBP04839DB00514DextromethorphanCytochrome b-245 heavy chainsmall moleculeapproved

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RelatedDiseases for CYBB_ADAM10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYBBC1844376Granulomatous Disease, Chronic, X-Linked20UNIPROT
HgeneCYBBC0018203Chronic granulomatous disease2CTD_human;ORPHANET
HgeneCYBBC0020538Hypertensive disease2CTD_human
HgeneCYBBC0011849Diabetes Mellitus1CTD_human
HgeneCYBBC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneCYBBC0018801Heart failure1CTD_human
HgeneCYBBC0022658Kidney Diseases1CTD_human
HgeneCYBBC0022661Kidney Failure, Chronic1CTD_human
HgeneCYBBC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCYBBC0027055Myocardial Reperfusion Injury1CTD_human
HgeneCYBBC0033687Proteinuria1CTD_human
HgeneCYBBC0035126Reperfusion Injury1CTD_human
HgeneCYBBC0751955Brain Infarction1CTD_human
HgeneCYBBC1970859Atypical Mycobacteriosis, Familial, X-Linked 21ORPHANET;UNIPROT
TgeneADAM10C3810041ALZHEIMER DISEASE 182UNIPROT
TgeneADAM10C0406811Reticulate acropigmentation of Kitamura1ORPHANET;UNIPROT
TgeneADAM10C1458155Mammary Neoplasms1CTD_human