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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9109

FusionGeneSummary for CYBA_CYBA

check button Fusion gene summary
Fusion gene informationFusion gene name: CYBA_CYBA
Fusion gene ID: 9109
HgeneTgene
Gene symbol

CYBA

CYBA

Gene ID

1535

1535

Gene namecytochrome b-245 alpha chaincytochrome b-245 alpha chain
Synonymsp22-PHOXp22-PHOX
Cytomap

16q24.2

16q24.2

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b-245 light chaincytochrome b light chaincytochrome b(558) alpha chaincytochrome b(558) alpha-subunitcytochrome b, alpha polypeptidecytochrome b-245, alpha polypeptidecytochrome b558 subunit alphaflavocytochrome b-558 alpha polypeptidencytochrome b-245 light chaincytochrome b light chaincytochrome b(558) alpha chaincytochrome b(558) alpha-subunitcytochrome b, alpha polypeptidecytochrome b-245, alpha polypeptidecytochrome b558 subunit alphaflavocytochrome b-558 alpha polypeptiden
Modification date2018052320180523
UniProtAcc

P13498

P13498

Ensembl transtripts involved in fusion geneENST00000261623, ENST00000567174, 
ENST00000569359, ENST00000561972, 
ENST00000261623, ENST00000567174, 
ENST00000569359, ENST00000561972, 
Fusion gene scores* DoF score3 X 3 X 1=92 X 2 X 2=8
# samples 32
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: CYBA [Title/Abstract] AND CYBA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYBA

GO:0017004

cytochrome complex assembly

7938008

HgeneCYBA

GO:0032755

positive regulation of interleukin-6 production

22423966

HgeneCYBA

GO:0032760

positive regulation of tumor necrosis factor production

22423966

HgeneCYBA

GO:0034137

positive regulation of toll-like receptor 2 signaling pathway

22423966

HgeneCYBA

GO:0050766

positive regulation of phagocytosis

22423966

HgeneCYBA

GO:1900426

positive regulation of defense response to bacterium

22423966

HgeneCYBA

GO:1903428

positive regulation of reactive oxygen species biosynthetic process

22423966

TgeneCYBA

GO:0017004

cytochrome complex assembly

7938008

TgeneCYBA

GO:0032755

positive regulation of interleukin-6 production

22423966

TgeneCYBA

GO:0032760

positive regulation of tumor necrosis factor production

22423966

TgeneCYBA

GO:0034137

positive regulation of toll-like receptor 2 signaling pathway

22423966

TgeneCYBA

GO:0050766

positive regulation of phagocytosis

22423966

TgeneCYBA

GO:1900426

positive regulation of defense response to bacterium

22423966

TgeneCYBA

GO:1903428

positive regulation of reactive oxygen species biosynthetic process

22423966


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW374327CYBAchr16

88712577

-CYBAchr16

88713562

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000261623ENST00000261623CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000261623ENST00000567174CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000261623ENST00000569359CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-intronENST00000261623ENST00000561972CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000567174ENST00000261623CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000567174ENST00000567174CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000567174ENST00000569359CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-intronENST00000567174ENST00000561972CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000569359ENST00000261623CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000569359ENST00000567174CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000569359ENST00000569359CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-intronENST00000569359ENST00000561972CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000561972ENST00000261623CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000561972ENST00000567174CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-3CDSENST00000561972ENST00000569359CYBAchr16

88712577

-CYBAchr16

88713562

-
intron-intronENST00000561972ENST00000561972CYBAchr16

88712577

-CYBAchr16

88713562

-

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FusionProtFeatures for CYBA_CYBA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYBA

P13498

CYBA

P13498

Critical component of the membrane-bound oxidase ofphagocytes that generates superoxide. Associates with NOX3 to forma functional NADPH oxidase constitutively generating superoxide.{ECO:0000269|PubMed:15824103}. Critical component of the membrane-bound oxidase ofphagocytes that generates superoxide. Associates with NOX3 to forma functional NADPH oxidase constitutively generating superoxide.{ECO:0000269|PubMed:15824103}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYBA_CYBA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYBA_CYBA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYBA_CYBA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CYBA_CYBA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYBAC1856255Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative5CTD_human;UNIPROT
HgeneCYBAC0020538Hypertensive disease3CTD_human
HgeneCYBAC0011853Diabetes Mellitus, Experimental2CTD_human
HgeneCYBAC0004153Atherosclerosis1CTD_human
HgeneCYBAC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneCYBAC0018203Chronic granulomatous disease1CTD_human;ORPHANET
HgeneCYBAC0018799Heart Diseases1CTD_human
HgeneCYBAC0022661Kidney Failure, Chronic1CTD_human
HgeneCYBAC0023890Liver Cirrhosis1CTD_human
HgeneCYBAC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCYBAC1565489Renal Insufficiency1CTD_human
TgeneCYBAC1856255Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative5CTD_human;UNIPROT
TgeneCYBAC0020538Hypertensive disease3CTD_human
TgeneCYBAC0011853Diabetes Mellitus, Experimental2CTD_human
TgeneCYBAC0004153Atherosclerosis1CTD_human
TgeneCYBAC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneCYBAC0018203Chronic granulomatous disease1CTD_human;ORPHANET
TgeneCYBAC0018799Heart Diseases1CTD_human
TgeneCYBAC0022661Kidney Failure, Chronic1CTD_human
TgeneCYBAC0023890Liver Cirrhosis1CTD_human
TgeneCYBAC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCYBAC1565489Renal Insufficiency1CTD_human