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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9089

FusionGeneSummary for CYB561_PSPH

check button Fusion gene summary
Fusion gene informationFusion gene name: CYB561_PSPH
Fusion gene ID: 9089
HgeneTgene
Gene symbol

CYB561

PSPH

Gene ID

1534

5723

Gene namecytochrome b561phosphoserine phosphatase
SynonymsCYB561A1|FRRS2PSP|PSPHD
Cytomap

17q23.3

7p11.2

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b561cytochrome b-561cytochrome b561 family, member A1ferric-chelate reductase 2phosphoserine phosphataseL-3-phosphoserine phosphataseO-phosphoserine phosphohydrolasePSPase
Modification date2018052320180523
UniProtAcc

P49447

P78330

Ensembl transtripts involved in fusion geneENST00000392975, ENST00000360793, 
ENST00000584031, ENST00000392976, 
ENST00000582297, ENST00000581573, 
ENST00000448884, ENST00000582034, 
ENST00000542042, ENST00000581163, 
ENST00000582997, 		ENST00000275605, 
ENST00000395471, ENST00000459834, 
Fusion gene scores* DoF score10 X 6 X 5=30012 X 13 X 4=624
# samples 1114
** MAII scorelog2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/624*10)=-2.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYB561 [Title/Abstract] AND PSPH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePSPH

GO:0006563

L-serine metabolic process

15291819


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI199927CYB561chr17

61513478

-PSPHchr7

56119538

+
ChiTaRS3.1BF314617CYB561chr17

61513478

-PSPHchr7

56119538

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000392975ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000392975ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000392975ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000360793ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000360793ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000360793ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000584031ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000584031ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000584031ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000392976ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000392976ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000392976ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000582297ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000582297ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000582297ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000581573ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000581573ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000581573ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000448884ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000448884ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000448884ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000582034ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000582034ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000582034ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000542042ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000542042ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000542042ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000581163ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000581163ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000581163ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000582997ENST00000275605CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000582997ENST00000395471CYB561chr17

61513478

-PSPHchr7

56119538

+
intron-intronENST00000582997ENST00000459834CYB561chr17

61513478

-PSPHchr7

56119538

+

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FusionProtFeatures for CYB561_PSPH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYB561

P49447

PSPH

P78330

Secretory vesicle-specific electron transport protein. Catalyzes the last step in the biosynthesis of serinefrom carbohydrates. The reaction mechanism proceeds via theformation of a phosphoryl-enzyme intermediates.{ECO:0000269|PubMed:12777757}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYB561_PSPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYB561_PSPH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYB561_PSPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePSPHP78330DB01593ZincPhosphoserine phosphatasesmall moleculeapproved|investigational

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RelatedDiseases for CYB561_PSPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePSPHC0002514Amino Acid Metabolism, Inborn Errors1CTD_human
TgenePSPHC1291463Deficiency of phosphoserine phosphatase1ORPHANET;UNIPROT