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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9067

FusionGeneSummary for CXCL9_CARD6

check button Fusion gene summary
Fusion gene informationFusion gene name: CXCL9_CARD6
Fusion gene ID: 9067
HgeneTgene
Gene symbol

CXCL9

CARD6

Gene ID

4283

84674

Gene nameC-X-C motif chemokine ligand 9caspase recruitment domain family member 6
SynonymsCMK|Humig|MIG|SCYB9|crg-10CINCIN1
Cytomap

4q21.1

5p13.1

Type of geneprotein-codingprotein-coding
DescriptionC-X-C motif chemokine 9chemokine (C-X-C motif) ligand 9gamma-interferon-induced monokinemonokine induced by gamma interferonmonokine induced by interferon-gammasmall-inducible cytokine B9caspase recruitment domain-containing protein 6CARD-containing inhibitor of Nod1 and Cardiak-induced NF-kB activationcaspase recruitment domain protein 6
Modification date2018052320180519
UniProtAcc

Q07325

Q9BX69

Ensembl transtripts involved in fusion geneENST00000264888, ENST00000254691, 
ENST00000381677, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: CXCL9 [Title/Abstract] AND CARD6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCXCL9

GO:0006935

chemotaxis

12782716

HgeneCXCL9

GO:0030816

positive regulation of cAMP metabolic process

12782716

HgeneCXCL9

GO:0042127

regulation of cell proliferation

12782716

HgeneCXCL9

GO:0043950

positive regulation of cAMP-mediated signaling

12782716

HgeneCXCL9

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

12782716


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW801916CXCL9chr4

76924792

-CARD6chr5

40842770

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000264888ENST00000254691CXCL9chr4

76924792

-CARD6chr5

40842770

+
intron-intronENST00000264888ENST00000381677CXCL9chr4

76924792

-CARD6chr5

40842770

+

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FusionProtFeatures for CXCL9_CARD6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CXCL9

Q07325

CARD6

Q9BX69

Cytokine that affects the growth, movement, oractivation state of cells that participate in immune andinflammatory response. Chemotactic for activated T-cells. Binds toCXCR3. May be involved in apoptosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CXCL9_CARD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CXCL9_CARD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CXCL9_CARD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CXCL9_CARD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCXCL9C0002171Alopecia Areata1CTD_human
HgeneCXCL9C0020517Hypersensitivity1CTD_human
HgeneCXCL9C0023892Biliary cirrhosis1CTD_human
HgeneCXCL9C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCXCL9C0023904Liver Neoplasms, Experimental1CTD_human
HgeneCXCL9C0027643Neoplasm Recurrence, Local1CTD_human
HgeneCXCL9C0032285Pneumonia1CTD_human
HgeneCXCL9C0282488Interstitial Cystitis1CTD_human
HgeneCXCL9C0345967Malignant mesothelioma1CTD_human
HgeneCXCL9C1458155Mammary Neoplasms1CTD_human