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Fusion gene ID: 9064 |
FusionGeneSummary for CXCL16_TEKT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CXCL16_TEKT1 | Fusion gene ID: 9064 | Hgene | Tgene | Gene symbol | CXCL16 | TEKT1 | Gene ID | 58191 | 83659 |
| Gene name | C-X-C motif chemokine ligand 16 | tektin 1 | |
| Synonyms | CXCLG16|SR-PSOX|SRPSOX | - | |
| Cytomap | 17p13.2 | 17p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C-X-C motif chemokine 16CXC chemokine ligand 16chemokine (C-X-C motif) ligand 16scavenger receptor for phosphatidylserine and oxidized low density lipoproteinsmall-inducible cytokine B16transmembrane chemokine CXCL16 | tektin-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H2A7 | Q969V4 | |
| Ensembl transtripts involved in fusion gene | ENST00000293778, ENST00000576153, ENST00000574412, | ENST00000338694, ENST00000535086, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 4=80 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CXCL16 [Title/Abstract] AND TEKT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CXCL16 | GO:0034097 | response to cytokine | 18373975 |
| Hgene | CXCL16 | GO:0034341 | response to interferon-gamma | 18373975 |
| Hgene | CXCL16 | GO:0034612 | response to tumor necrosis factor | 18373975 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-OL-A66P-01A | CXCL16 | chr17 | 4641703 | - | TEKT1 | chr17 | 6722677 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000293778 | ENST00000338694 | CXCL16 | chr17 | 4641703 | - | TEKT1 | chr17 | 6722677 | - |
| 5CDS-intron | ENST00000293778 | ENST00000535086 | CXCL16 | chr17 | 4641703 | - | TEKT1 | chr17 | 6722677 | - |
| intron-3CDS | ENST00000576153 | ENST00000338694 | CXCL16 | chr17 | 4641703 | - | TEKT1 | chr17 | 6722677 | - |
| intron-intron | ENST00000576153 | ENST00000535086 | CXCL16 | chr17 | 4641703 | - | TEKT1 | chr17 | 6722677 | - |
| In-frame | ENST00000574412 | ENST00000338694 | CXCL16 | chr17 | 4641703 | - | TEKT1 | chr17 | 6722677 | - |
| 5CDS-intron | ENST00000574412 | ENST00000535086 | CXCL16 | chr17 | 4641703 | - | TEKT1 | chr17 | 6722677 | - |
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FusionProtFeatures for CXCL16_TEKT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CXCL16 | TEKT1 |
| Acts as a scavenger receptor on macrophages, whichspecifically binds to OxLDL (oxidized low density lipoprotein),suggesting that it may be involved in pathophysiology such asatherogenesis (By similarity). Induces a strong chemotacticresponse. Induces calcium mobilization. Binds to CXCR6/Bonzo.{ECO:0000250}. | Structural component of ciliary and flagellarmicrotubules. Forms filamentous polymers in the walls of ciliaryand flagellar microtubules. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CXCL16_TEKT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CXCL16_ENST00000574412_chr17_4641703_-_TEKT1_ENST00000338694_chr17_6722677_-_475aa MSGSQSEVAPSPQSPRSPEMGRDLRPGSRVLLLLLLLLLVYLTQPGNGNEGSVTGSCYCGKRISSDSPPSVQFMNRLRKHLRAYHRCLYY TRFQLLSWSVCGGNKDPWVQELMSCLDLKEQRLEEVQFWKKELDDKLEQLVNVTDDLLIYKIRLEKALETLKEPLHITETCLAYREKRIG IDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQIRMNRSAKYNLEKDLKDKFVALTIDDICFSLNNNSPNIRYSENAVRIEPNSVSL EDWLDFSSTNVEKADKQRNNSLMLKALVDRILSQTANDLRKQCDVVDTAFKNGLKDTKDARDKLADHLAKVMEEIASQEKNITALEKAIL DQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLMKEVQEITHNVARLKETLAQAQAELKGLHRRQLALQEEIQVKENTIYIDEVLCMQMR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CXCL16_ENST00000574412_chr17_4641703_-_TEKT1_ENST00000338694_chr17_6722677_-_1425nt ATGTCTGGGAGTCAGAGCGAGGTGGCTCCATCCCCGCAGAGTCCGCGGAGCCCCGAGATGGGACGGGACTTGCGGCCCGGGTCCCGCGTG CTCCTGCTCCTGCTTCTGCTCCTGCTGGTGTACCTGACTCAGCCAGGCAATGGCAACGAGGGCAGCGTCACTGGAAGTTGTTATTGTGGT AAAAGAATTTCTTCCGACTCCCCGCCATCGGTTCAGTTCATGAATCGTCTCCGGAAACACCTGAGAGCTTACCATCGGTGTCTATACTAC ACGAGGTTCCAGCTCCTTTCCTGGAGCGTGTGTGGGGGCAACAAGGACCCATGGGTTCAGGAATTGATGAGCTGTCTTGATCTCAAAGAA CAGAGACTCGAGGAAGTCCAGTTCTGGAAGAAGGAGTTAGATGACAAACTTGAGCAGCTTGTGAATGTAACTGATGATCTACTCATATAT AAGATCAGATTGGAAAAAGCCCTGGAGACCTTGAAAGAGCCCTTGCACATCACTGAGACATGCCTGGCATACAGGGAGAAGCGCATTGGC ATTGACCTGGTGCACGACACAGTGGAGCATGAGCTGATAAAGGAGGCTGAGATCATCCAGGGCATTATGGCTCTGCTGACCCGTACCTTG GAGGAGGCTTCCGAGCAGATTCGGATGAACCGCTCTGCCAAGTACAATCTTGAGAAGGATTTGAAGGACAAGTTTGTGGCCCTGACCATA GATGATATCTGCTTCTCGCTCAACAACAACTCACCAAACATCAGATATTCTGAGAACGCCGTGAGGATTGAGCCAAACTCCGTGAGTCTG GAAGACTGGTTGGACTTCTCCAGCACCAATGTGGAGAAGGCTGACAAGCAGCGGAACAACTCCCTGATGCTGAAAGCCCTGGTGGATCGA ATCCTGTCCCAGACAGCCAATGATCTGCGCAAGCAGTGTGATGTGGTGGACACGGCATTCAAGAATGGGCTGAAGGATACAAAGGATGCC AGGGACAAGCTGGCTGATCATCTGGCCAAGGTCATGGAAGAGATTGCTTCCCAGGAGAAAAATATTACAGCTCTTGAAAAGGCCATCCTT GACCAAGAAGGGCCAGCCAAGGTGGCTCATACGCGCTTGGAGACCAGGACACACCGGCCGAACGTGGAGCTGTGTCGTGATGTCGCACAA TATAGGCTAATGAAGGAGGTTCAAGAGATCACCCACAATGTCGCAAGATTGAAGGAAACTTTAGCCCAAGCTCAGGCAGAGCTGAAAGGG CTGCATCGCAGACAGCTTGCCCTGCAGGAGGAGATCCAGGTCAAAGAGAACACCATTTATATCGACGAAGTGCTGTGTATGCAGATGAGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CXCL16_ENST00000574412_chr17_4641703_-_TEKT1_ENST00000338694_chr17_6722677_-_3985nt TCCGCGGGTGGCTGCCCCGCAGGTGCGCGCGGCCGGGGCTGGCGGCGACTCTCTCCACCGGGCCGCCCGGGAGGCTCATGCAGCGCGGCT GGGTCCCGCGGCGCCCGGATCGGGGAAGTGAAAGTGCCTCGGAGGAGGAGGGCCGGTCCGGCAGTGCAGCCGCCTCACAGGTCGGCGGAC GGGCCAGGCGGGCGGCCTCCTGAACCGAACCGAATCGGCTCCTCGGGCCGTCGTCCTCCCGCCCCTCCTCGCCCGCCGCCGGAGTTTTCT TTCGGTTTCTTCCAAGATTCCTGGCCTTCCCTCGACGGAGCCGGGCCCAGTGCGGGGGCGCAGGGCGCGGGAGCTCCACCTCCTCGGCTT TCCCTGCGTCCAGAGGCTGGCATGGCGCGGGCCGAGTACTGAGCGCACGGTCGGGGCACAGCAGGGCCGGGGGGTGCAGCTGGCTCGCGC CTCCTCTCCGGCCGCCGTCTCCTCCGGTCCCCGGCGAAAGCCATTGAGACACCAGCTGGACGTCACGCGCCGGAGCATGTCTGGGAGTCA GAGCGAGGTGGCTCCATCCCCGCAGAGTCCGCGGAGCCCCGAGATGGGACGGGACTTGCGGCCCGGGTCCCGCGTGCTCCTGCTCCTGCT TCTGCTCCTGCTGGTGTACCTGACTCAGCCAGGCAATGGCAACGAGGGCAGCGTCACTGGAAGTTGTTATTGTGGTAAAAGAATTTCTTC CGACTCCCCGCCATCGGTTCAGTTCATGAATCGTCTCCGGAAACACCTGAGAGCTTACCATCGGTGTCTATACTACACGAGGTTCCAGCT CCTTTCCTGGAGCGTGTGTGGGGGCAACAAGGACCCATGGGTTCAGGAATTGATGAGCTGTCTTGATCTCAAAGAACAGAGACTCGAGGA AGTCCAGTTCTGGAAGAAGGAGTTAGATGACAAACTTGAGCAGCTTGTGAATGTAACTGATGATCTACTCATATATAAGATCAGATTGGA AAAAGCCCTGGAGACCTTGAAAGAGCCCTTGCACATCACTGAGACATGCCTGGCATACAGGGAGAAGCGCATTGGCATTGACCTGGTGCA CGACACAGTGGAGCATGAGCTGATAAAGGAGGCTGAGATCATCCAGGGCATTATGGCTCTGCTGACCCGTACCTTGGAGGAGGCTTCCGA GCAGATTCGGATGAACCGCTCTGCCAAGTACAATCTTGAGAAGGATTTGAAGGACAAGTTTGTGGCCCTGACCATAGATGATATCTGCTT CTCGCTCAACAACAACTCACCAAACATCAGATATTCTGAGAACGCCGTGAGGATTGAGCCAAACTCCGTGAGTCTGGAAGACTGGTTGGA CTTCTCCAGCACCAATGTGGAGAAGGCTGACAAGCAGCGGAACAACTCCCTGATGCTGAAAGCCCTGGTGGATCGAATCCTGTCCCAGAC AGCCAATGATCTGCGCAAGCAGTGTGATGTGGTGGACACGGCATTCAAGAATGGGCTGAAGGATACAAAGGATGCCAGGGACAAGCTGGC TGATCATCTGGCCAAGGTCATGGAAGAGATTGCTTCCCAGGAGAAAAATATTACAGCTCTTGAAAAGGCCATCCTTGACCAAGAAGGGCC AGCCAAGGTGGCTCATACGCGCTTGGAGACCAGGACACACCGGCCGAACGTGGAGCTGTGTCGTGATGTCGCACAATATAGGCTAATGAA GGAGGTTCAAGAGATCACCCACAATGTCGCAAGATTGAAGGAAACTTTAGCCCAAGCTCAGGCAGAGCTGAAAGGGCTGCATCGCAGACA GCTTGCCCTGCAGGAGGAGATCCAGGTCAAAGAGAACACCATTTATATCGACGAAGTGCTGTGTATGCAGATGAGGAAATCCATCCCACT TCGGGATGGGGAAGACCATGGGGTCTGGGCTGGGGGCCTCCGCCCTGATGCTGTCTGCTAATAGTAGGGCTAGTTCCAATTCTCATTAAA CCACATTGTAAACAGTAGTTACAGTAGTACAGAGCTCTCATTTCAGGCTGGCGGGGCCTCTAGCCAGCCTGCTGCAACCTCTTGGCTGGC ATTCCAAGCCTGCTCAGGGGGCTGATTTTGGGGCGAGTTTCTTCTCTTATGCTGGTGTGGTGTTTGCCTAACAATTCAACTCCATATTTT AGCACAGGCCACTCTTACAATATCACAGGACTTGGGGCCCCAGGACAGGGTTTCAAGACATTTCAGTTCAGATTCAATTCAATAAAGTAG TTGGGCTGGATCACCTGTGTAGACCATGCCCCTCTTGCTCATGAGATGGGATGCTAACCTTTCTCTTGGCTCTCAAAATTTCTTTTCTCT AGAAAATAATGTGTTTTTTTTCTCTTAAATACTCAAATAACATAAAGAAAAAGAACAAAATTCCATTCATTCAAGTCAATGGGTTCAAGT CAATGGTTAAGACTGTAGGTTCCGGAGTCTGCCATCTGAGTATAGGACCTCCAATAGTCCCCACTCACAGGGCTATAGGGGCGTTGAATG AGATCACCTCCGTAAAGGGCTTCATACTGAGCCTGTATCATGGGGCAGTGAGTGTTTAATGAATGTGAGCCATTGTGAGCAGTCCCACCC TATACCAACATAATTTCTGCACAATTGTACTCATGGCATAAACTCAATTTCAGGATTATTTTTTTCCTTCACTGCTAATTATTGCAAGCC TTTGTTCATGTTGCTAAATTGTCTTTATAATTATTTTAATGGTTACGTACCTCTTTACAAGTTTTCAGCAAGACTGTTTTATATACTTAC TGTTTCTTTTCCAAAAAGAGTTCAACTTGTGGGAGGCTGCCTTCCGCTGAGCTGCAGCAGGTCAGAGATCTATGTGGGTGACTGTCAAAG GAAGACATTTGCTGTGGGAAACTGCTCATTTGTTCCTTATTCCGCTAACATTGAAGGAACACTTTCCATGGACGAGGCTTACCATCTCAG CACCCTCCCATGTGTGAAGCTGCTGCTACACTCTGCTAACATTTGGTTCCCCGGTGCTCATGGACAGCTGACGGTGTGGGGCTCAGGAGA CCTAGCTTCTAGTTGCAACACTGCCAGGAAAGTTTCTCTCCTTCTTTAGGACCACCTGTAAAGTAAGGAAAGGACTATATCGTCTGGAAC TCTTCCTGTCCTTGCTGTTCCCTGAATCTGGCTGTCTAGCTGCACATACGGTGTCATAGGGCACAATGATAATGCAGAGTGTGGGCCTAA TTCCTGGGAGCTTTGCAATCTAGGTGCTCCTTGGTCCAGAGACTCTTTGCCATCAGAAAGGGATGTTCCCAATCTGGGATGGAGAAACCC CCTTTGAGGCCAAAAGCACTGGCTTAATTCTGTTAATTCTGATCTATGCCACCCCAGTGCTGAACGTCTCCTCTCAGAGTGCTCAGCAAA TACACAGCCCTTCCCATGCCTCAATCAAGGAGGGAGGCCCCTCTCTGCTCACTGGGAAGCCTCTGGGTGCTTTTCTGCTCTGGCTCGGAA GAGTCCAAATAAGCCTTCCCAGCTCACTGGGCAGACCTCAGAGTTTCTGCTAACTTAGCAGGGTTTTGAGGTCTGTCCCAGAGGATGTGG CTGGCAGGGTGTGAAGACACTGGGCAAAATCCTTCCTTGTGAATACAGCTCTCAGAGGCAGCCAGCCTCAGTGGTGGATTCAGATCCCAG GCTCTGCAGGGAGATGTGATTCAGATCAGCTGGTGGATCAGCTCCACGCTCTACCTGTGATGTGATCCCCGCCAAGTTACTCAACTTCCC CGAGCTTCAGTTGCCTAATCTGTAAATAAGACTAATAAAGCCTAGATTGGCGAGATAACGTGTGGAAGACTCTCAACACAGTGTCTGGAA CATGCTGCTTTTAAGGGAAATGTGATTTTGATTATGGTTGAGGCCATTTCTCAACATGTAGACATAAAATGCGGAAACATCTAAGATTTC |
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FusionGenePPI for CXCL16_TEKT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CXCL16 | ELAVL1, APP, KRTAP5-9, MDFI, MTUS2, ADAMTSL4, CCDC155, KRTAP10-7, KRTAP10-9, KRTAP10-1, KRTAP10-3, NOTCH2NL, TMEM239, KRAS, LMNA | TEKT1 | BYSL, CHD2, HNRNPH2, PRKAG1, SDCBP, VCL, NCAPD3, CCHCR1, GAN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CXCL16_TEKT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CXCL16_TEKT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CXCL16 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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