![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 9062 |
FusionGeneSummary for CXCL14_DCAF16 |
![]() |
Fusion gene information | Fusion gene name: CXCL14_DCAF16 | Fusion gene ID: 9062 | Hgene | Tgene | Gene symbol | CXCL14 | DCAF16 | Gene ID | 9547 | 54876 |
Gene name | C-X-C motif chemokine ligand 14 | DDB1 and CUL4 associated factor 16 | |
Synonyms | BMAC|BRAK|KEC|KS1|MIP-2g|MIP2G|NJAC|SCYB14 | C4orf30 | |
Cytomap | 5q31.1 | 4p15.31 | |
Type of gene | protein-coding | protein-coding | |
Description | C-X-C motif chemokine 14CXC chemokine in breast and kidneyMIP-2 gammabolekinebreast and kidneychemokine (C-X-C motif) ligand 14chemokine BRAKsmall inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK)small-inducible cytokine B14tumor-suppr | DDB1- and CUL4-associated factor 16 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O95715 | Q9NXF7 | |
Ensembl transtripts involved in fusion gene | ENST00000337225, ENST00000512158, | ENST00000382247, ENST00000536863, ENST00000507768, | |
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CXCL14 [Title/Abstract] AND DCAF16 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB217634 | CXCL14 | chr5 | 134914166 | + | DCAF16 | chr4 | 17803054 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000337225 | ENST00000382247 | CXCL14 | chr5 | 134914166 | + | DCAF16 | chr4 | 17803054 | + |
intron-3UTR | ENST00000337225 | ENST00000536863 | CXCL14 | chr5 | 134914166 | + | DCAF16 | chr4 | 17803054 | + |
intron-intron | ENST00000337225 | ENST00000507768 | CXCL14 | chr5 | 134914166 | + | DCAF16 | chr4 | 17803054 | + |
intron-3UTR | ENST00000512158 | ENST00000382247 | CXCL14 | chr5 | 134914166 | + | DCAF16 | chr4 | 17803054 | + |
intron-3UTR | ENST00000512158 | ENST00000536863 | CXCL14 | chr5 | 134914166 | + | DCAF16 | chr4 | 17803054 | + |
intron-intron | ENST00000512158 | ENST00000507768 | CXCL14 | chr5 | 134914166 | + | DCAF16 | chr4 | 17803054 | + |
Top |
FusionProtFeatures for CXCL14_DCAF16 |
![]() |
Hgene | Tgene |
CXCL14 | DCAF16 |
Potent chemoattractant for neutrophils, and weaker fordendritic cells. Not chemotactic for T-cells, B-cells, monocytes,natural killer cells or granulocytes. Does not inhibitproliferation of myeloid progenitors in colony formation assays.{ECO:0000269|PubMed:10049774, ECO:0000269|PubMed:10946286}. | May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CXCL14_DCAF16 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CXCL14_DCAF16 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CXCL14_DCAF16 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CXCL14_DCAF16 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CXCL14 | C0004096 | Asthma | 1 | CTD_human |
Hgene | CXCL14 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | CXCL14 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | CXCL14 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | CXCL14 | C0236969 | Substance-Related Disorders | 1 | CTD_human |