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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9058

FusionGeneSummary for CXCL13_UTRN

check button Fusion gene summary
Fusion gene informationFusion gene name: CXCL13_UTRN
Fusion gene ID: 9058
HgeneTgene
Gene symbol

CXCL13

UTRN

Gene ID

10563

7402

Gene nameC-X-C motif chemokine ligand 13utrophin
SynonymsANGIE|ANGIE2|BCA-1|BCA1|BLC|BLR1L|SCYB13DMDL|DRP|DRP1
Cytomap

4q21.1

6q24.2

Type of geneprotein-codingprotein-coding
DescriptionC-X-C motif chemokine 13B-cell chemoattractantB-cell-attracting chemokine 1B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)B-lymphocyte chemoattractantCXC chemokine BLCb cell-attracting chemokine 1b lymphocyte chemoattractantchemutrophinDRP-1dystrophin-related protein 1
Modification date2018052320180519
UniProtAcc

O43927

P46939

Ensembl transtripts involved in fusion geneENST00000286758, ENST00000367545, 
ENST00000367526, ENST00000480333, 
Fusion gene scores* DoF score1 X 1 X 1=133 X 9 X 9=2673
# samples 133
** MAII scorelog2(1/1*10)=3.32192809488736log2(33/2673*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CXCL13 [Title/Abstract] AND UTRN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCXCL13

GO:0007166

cell surface receptor signaling pathway

11554781

HgeneCXCL13

GO:0007204

positive regulation of cytosolic calcium ion concentration

11554781

HgeneCXCL13

GO:0007267

cell-cell signaling

11554781

HgeneCXCL13

GO:0010820

positive regulation of T cell chemotaxis

11554781

HgeneCXCL13

GO:0035754

B cell chemotaxis

9463416

HgeneCXCL13

GO:0035768

endothelial cell chemotaxis to fibroblast growth factor

11708770

HgeneCXCL13

GO:0042742

defense response to bacterium

17562761

HgeneCXCL13

GO:2000545

negative regulation of endothelial cell chemotaxis to fibroblast growth factor

11708770


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-85-7950-01ACXCL13chr4

78532988

+UTRNchr6

144665237

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000286758ENST00000367545CXCL13chr4

78532988

+UTRNchr6

144665237

+
5CDS-intronENST00000286758ENST00000367526CXCL13chr4

78532988

+UTRNchr6

144665237

+
5CDS-intronENST00000286758ENST00000480333CXCL13chr4

78532988

+UTRNchr6

144665237

+

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FusionProtFeatures for CXCL13_UTRN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CXCL13

O43927

UTRN

P46939

Chemotactic for B-lymphocytes but not for T-lymphocytes,monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5. May play a role in anchoring the cytoskeleton to theplasma membrane. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CXCL13_UTRN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CXCL13_UTRN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CXCL13EEF1G, CXCR3, CDKN1A, ACKR4UTRNSNTA1, SNTB2, DAG1, UTRN, DTNA, PGM5, USP21, MARK2, PIK3CG, TERF1, TERF2, MME, DISC1, SIRT7, THOC1, RRP9, THOC2, THOC6, THOC5, UBE2D1, ZC3H15, XPO4, THOC3, UBE3C, PTPN12, NPM1, ADRA1D, LATS2, SAV1, OBSL1, CCDC8, L3HYPDH, IER2, USP7, CALM1, PTEN, MED4, TMEM17, PDK3, PI4KB, TTK, RBM8A, MCM2, ATOH1, CDH1, TENC1, TNS1, TNS3, SNTG2, NDEL1, DMD, CPNE5, FAM167A, RHPN1, PTRF, VHL, CPNE4, TTC30B, FAM189B, PHF19, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CXCL13_UTRN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneUTRNP46939DB01593ZincUtrophinsmall moleculeapproved|investigational

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RelatedDiseases for CXCL13_UTRN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCXCL13C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCXCL13C0345967Malignant mesothelioma1CTD_human