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Fusion gene ID: 9056 |
FusionGeneSummary for CXCL12_CXCL12 |
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Fusion gene information | Fusion gene name: CXCL12_CXCL12 | Fusion gene ID: 9056 | Hgene | Tgene | Gene symbol | CXCL12 | CXCL12 | Gene ID | 6387 | 6387 |
Gene name | C-X-C motif chemokine ligand 12 | C-X-C motif chemokine ligand 12 | |
Synonyms | IRH|PBSF|SCYB12|SDF1|TLSF|TPAR1 | IRH|PBSF|SCYB12|SDF1|TLSF|TPAR1 | |
Cytomap | 10q11.21 | 10q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | stromal cell-derived factor 1chemokine (C-X-C motif) ligand 12intercrine reduced in hepatomaspre-B cell growth-stimulating factor | stromal cell-derived factor 1chemokine (C-X-C motif) ligand 12intercrine reduced in hepatomaspre-B cell growth-stimulating factor | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | P48061 | P48061 | |
Ensembl transtripts involved in fusion gene | ENST00000395795, ENST00000374429, ENST00000395793, ENST00000374426, ENST00000343575, ENST00000395794, ENST00000496375, | ENST00000395795, ENST00000374429, ENST00000395793, ENST00000374426, ENST00000343575, ENST00000395794, ENST00000496375, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 2 X 4=32 |
# samples | 2 | 4 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CXCL12 [Title/Abstract] AND CXCL12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CXCL12 | GO:0033622 | integrin activation | 29301984 |
Hgene | CXCL12 | GO:0045785 | positive regulation of cell adhesion | 23620790 |
Hgene | CXCL12 | GO:0060326 | cell chemotaxis | 18308860 |
Hgene | CXCL12 | GO:0070098 | chemokine-mediated signaling pathway | 20388803 |
Hgene | CXCL12 | GO:0090026 | positive regulation of monocyte chemotaxis | 18802065 |
Hgene | CXCL12 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 20388803 |
Hgene | CXCL12 | GO:1903237 | negative regulation of leukocyte tethering or rolling | 18308860 |
Hgene | CXCL12 | GO:2000406 | positive regulation of T cell migration | 23620790 |
Hgene | CXCL12 | GO:2000669 | negative regulation of dendritic cell apoptotic process | 15059845 |
Tgene | CXCL12 | GO:0033622 | integrin activation | 29301984 |
Tgene | CXCL12 | GO:0045785 | positive regulation of cell adhesion | 23620790 |
Tgene | CXCL12 | GO:0060326 | cell chemotaxis | 18308860 |
Tgene | CXCL12 | GO:0070098 | chemokine-mediated signaling pathway | 20388803 |
Tgene | CXCL12 | GO:0090026 | positive regulation of monocyte chemotaxis | 18802065 |
Tgene | CXCL12 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 20388803 |
Tgene | CXCL12 | GO:1903237 | negative regulation of leukocyte tethering or rolling | 18308860 |
Tgene | CXCL12 | GO:2000406 | positive regulation of T cell migration | 23620790 |
Tgene | CXCL12 | GO:2000669 | negative regulation of dendritic cell apoptotic process | 15059845 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA678668 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000395795 | ENST00000395795 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-3UTR | ENST00000395795 | ENST00000374429 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395795 | ENST00000395793 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395795 | ENST00000374426 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395795 | ENST00000343575 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395795 | ENST00000395794 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395795 | ENST00000496375 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374429 | ENST00000395795 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-3UTR | ENST00000374429 | ENST00000374429 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374429 | ENST00000395793 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374429 | ENST00000374426 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374429 | ENST00000343575 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374429 | ENST00000395794 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374429 | ENST00000496375 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395793 | ENST00000395795 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-3UTR | ENST00000395793 | ENST00000374429 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395793 | ENST00000395793 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395793 | ENST00000374426 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395793 | ENST00000343575 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395793 | ENST00000395794 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395793 | ENST00000496375 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374426 | ENST00000395795 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-3UTR | ENST00000374426 | ENST00000374429 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374426 | ENST00000395793 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374426 | ENST00000374426 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374426 | ENST00000343575 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374426 | ENST00000395794 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000374426 | ENST00000496375 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000343575 | ENST00000395795 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-3UTR | ENST00000343575 | ENST00000374429 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000343575 | ENST00000395793 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000343575 | ENST00000374426 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000343575 | ENST00000343575 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000343575 | ENST00000395794 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000343575 | ENST00000496375 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395794 | ENST00000395795 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-3UTR | ENST00000395794 | ENST00000374429 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395794 | ENST00000395793 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395794 | ENST00000374426 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395794 | ENST00000343575 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395794 | ENST00000395794 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000395794 | ENST00000496375 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000496375 | ENST00000395795 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-3UTR | ENST00000496375 | ENST00000374429 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000496375 | ENST00000395793 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000496375 | ENST00000374426 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000496375 | ENST00000343575 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000496375 | ENST00000395794 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
intron-intron | ENST00000496375 | ENST00000496375 | CXCL12 | chr10 | 44865816 | + | CXCL12 | chr10 | 44865839 | - |
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FusionProtFeatures for CXCL12_CXCL12 |
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Hgene | Tgene |
CXCL12 | CXCL12 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CXCL12_CXCL12 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CXCL12_CXCL12 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CXCL12_CXCL12 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CXCL12 | P48061 | DB06822 | Tinzaparin | Stromal cell-derived factor 1 | small molecule | approved |
Tgene | CXCL12 | P48061 | DB06822 | Tinzaparin | Stromal cell-derived factor 1 | small molecule | approved |
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RelatedDiseases for CXCL12_CXCL12 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CXCL12 | C0027626 | Neoplasm Invasiveness | 3 | CTD_human |
Hgene | CXCL12 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Hgene | CXCL12 | C0022116 | Ischemia | 1 | CTD_human |
Hgene | CXCL12 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | CXCL12 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | CXCL12 | C0266929 | Chronic Periodontitis | 1 | CTD_human |
Hgene | CXCL12 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | CXCL12 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | CXCL12 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
Hgene | CXCL12 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | CXCL12 | C0027626 | Neoplasm Invasiveness | 3 | CTD_human |
Tgene | CXCL12 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Tgene | CXCL12 | C0022116 | Ischemia | 1 | CTD_human |
Tgene | CXCL12 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CXCL12 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | CXCL12 | C0266929 | Chronic Periodontitis | 1 | CTD_human |
Tgene | CXCL12 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | CXCL12 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | CXCL12 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
Tgene | CXCL12 | C2239176 | Liver carcinoma | 1 | CTD_human |