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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9044

FusionGeneSummary for CWC27_CWC27

check button Fusion gene summary
Fusion gene informationFusion gene name: CWC27_CWC27
Fusion gene ID: 9044
HgeneTgene
Gene symbol

CWC27

CWC27

Gene ID

10283

10283

Gene nameCWC27 spliceosome associated protein homologCWC27 spliceosome associated protein homolog
SynonymsNY-CO-10|RPSKA|SDCCAG-10|SDCCAG10NY-CO-10|RPSKA|SDCCAG-10|SDCCAG10
Cytomap

5q12.3

5q12.3

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase CWC27 homologPPIase CWC27PPIase SDCCAG10antigen NY-CO-10peptidyl-prolyl cis-trans isomerase SDCCAG10serologically defined colon cancer antigen 10peptidyl-prolyl cis-trans isomerase CWC27 homologPPIase CWC27PPIase SDCCAG10antigen NY-CO-10peptidyl-prolyl cis-trans isomerase SDCCAG10serologically defined colon cancer antigen 10
Modification date2018052320180523
UniProtAcc

Q6UX04

Q6UX04

Ensembl transtripts involved in fusion geneENST00000381070, ENST00000508024, 
ENST00000545000, 
ENST00000381070, 
ENST00000508024, ENST00000545000, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 3=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CWC27 [Title/Abstract] AND CWC27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG170618CWC27chr5

64064933

-CWC27chr5

64064973

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000381070ENST00000381070CWC27chr5

64064933

-CWC27chr5

64064973

+
5UTR-3CDSENST00000381070ENST00000508024CWC27chr5

64064933

-CWC27chr5

64064973

+
5UTR-intronENST00000381070ENST00000545000CWC27chr5

64064933

-CWC27chr5

64064973

+
5UTR-3CDSENST00000508024ENST00000381070CWC27chr5

64064933

-CWC27chr5

64064973

+
5UTR-3CDSENST00000508024ENST00000508024CWC27chr5

64064933

-CWC27chr5

64064973

+
5UTR-intronENST00000508024ENST00000545000CWC27chr5

64064933

-CWC27chr5

64064973

+
intron-3CDSENST00000545000ENST00000381070CWC27chr5

64064933

-CWC27chr5

64064973

+
intron-3CDSENST00000545000ENST00000508024CWC27chr5

64064933

-CWC27chr5

64064973

+
intron-intronENST00000545000ENST00000545000CWC27chr5

64064933

-CWC27chr5

64064973

+

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FusionProtFeatures for CWC27_CWC27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CWC27

Q6UX04

CWC27

Q6UX04

As part of the spliceosome, plays a role in pre-mRNAsplicing (PubMed:29360106). Probable inactive PPIase with nopeptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).{ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106}. As part of the spliceosome, plays a role in pre-mRNAsplicing (PubMed:29360106). Probable inactive PPIase with nopeptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).{ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CWC27_CWC27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CWC27_CWC27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CWC27_CWC27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CWC27_CWC27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource