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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9018

FusionGeneSummary for CUX1_MTMR7

check button Fusion gene summary
Fusion gene informationFusion gene name: CUX1_MTMR7
Fusion gene ID: 9018
HgeneTgene
Gene symbol

CUX1

MTMR7

Gene ID

1523

9108

Gene namecut like homeobox 1myotubularin related protein 7
SynonymsCASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GOLIM6|Nbla10317|p100|p110|p200|p75-
Cytomap

7q22.1

8p22

Type of geneprotein-codingprotein-coding
Descriptionprotein CASPCCAAT displacement proteincut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317myotubularin-related protein 7
Modification date2018052320180519
UniProtAcc

Q13948

Q9Y216

Ensembl transtripts involved in fusion geneENST00000437600, ENST00000292538, 
ENST00000393824, ENST00000547394, 
ENST00000360264, ENST00000425244, 
ENST00000292535, ENST00000549414, 
ENST00000556210, ENST00000550008, 
ENST00000546411, ENST00000560541, 
ENST00000180173, ENST00000521857, 
ENST00000398099, ENST00000523571, 
Fusion gene scores* DoF score20 X 18 X 9=32402 X 2 X 1=4
# samples 222
** MAII scorelog2(22/3240*10)=-3.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: CUX1 [Title/Abstract] AND MTMR7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI732560CUX1chr7

101525434

-MTMR7chr8

17262344

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000437600ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000437600ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000437600ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000437600ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000292538ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000292538ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000292538ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000292538ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000393824ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000393824ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000393824ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000393824ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000547394ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000547394ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000547394ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000547394ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000360264ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000360264ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000360264ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000360264ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000425244ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000425244ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000425244ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000425244ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000292535ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000292535ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000292535ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000292535ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000549414ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000549414ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000549414ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000549414ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000556210ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000556210ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000556210ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000556210ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000550008ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000550008ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000550008ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000550008ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000546411ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000546411ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000546411ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000546411ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000560541ENST00000180173CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000560541ENST00000521857CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000560541ENST00000398099CUX1chr7

101525434

-MTMR7chr8

17262344

-
intron-intronENST00000560541ENST00000523571CUX1chr7

101525434

-MTMR7chr8

17262344

-

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FusionProtFeatures for CUX1_MTMR7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUX1

Q13948

MTMR7

Q9Y216

May be involved in intra-Golgi retrograde transport.{ECO:0000269|PubMed:15718469}. Phosphatase that acts on lipids with a phosphoinositolheadgroup. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CUX1_MTMR7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CUX1_MTMR7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CUX1_MTMR7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CUX1_MTMR7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCUX1C0041696Unipolar Depression3PSYGENET
HgeneCUX1C1269683Major Depressive Disorder3PSYGENET
HgeneCUX1C0525045Mood Disorders1PSYGENET
HgeneCUX1C0596263Carcinogenesis1CTD_human
TgeneMTMR7C0023893Liver Cirrhosis, Experimental1CTD_human